Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jessica E. Ackerman"'
Autor:
Michael T. H. Ng, Rowie Borst, Hamez Gacaferi, Sarah Davidson, Jessica E. Ackerman, Peter A. Johnson, Caio C. Machado, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Lucy MacDonald, Stefano Alivernini, Micon Garvilles, Kathrin Jansen, Ananya Bhalla, Angela Lee, James Charlesworth, Rajat Chowdhury, Paul Klenerman, Kate Powell, Carl-Philip Hackstein, ICECAP Consortium, Dominic Furniss, Jonathan Rees, Derek Gilroy, Mark Coles, Andrew J. Carr, Stephen N. Sansom, Christopher D. Buckley, Stephanie G. Dakin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-i
Externí odkaz:
https://doaj.org/article/0ab5f854810c4af1beacea8e07505eca
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Tendon injuries heal via scar tissue rather than regeneration. This healing response forms adhesions between the flexor tendons in the hand and surrounding tissues, resulting in impaired range of motion and hand function. Mechanistically, in
Externí odkaz:
https://doaj.org/article/930aa5bc24584e0e8f7273072e04ab6d
Autor:
Jessica E Ackerman, Anne EC Nichols, Valentina Studentsova, Katherine T Best, Emma Knapp, Alayna E Loiselle
Publikováno v:
eLife, Vol 8 (2019)
Identification of pro-regenerative approaches to improve tendon healing is critically important as the fibrotic healing response impairs physical function. In the present study we tested the hypothesis that S100a4 haploinsufficiency or inhibition of
Externí odkaz:
https://doaj.org/article/1ffb29c4d1f24c7dac0c94373922909f
Autor:
Jessica E. Ackerman, Katherine T. Best, Samantha N. Muscat, Elizabeth M. Pritchett, Anne E.C. Nichols, Chia-Lung Wu, Alayna E. Loiselle
Publikováno v:
Cell reports. 41(8)
Tendon injuries heal via a scar-mediated response, and there are no biological approaches to promote more regenerative healing. Mouse flexor tendons heal through the formation of spatially distinct tissue areas: a highly aligned tissue bridge between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6889bd9c9a83cb3c6710f28d674a81
https://pubmed.ncbi.nlm.nih.gov/36417854
https://pubmed.ncbi.nlm.nih.gov/36417854
The tendon healing process is regulated by the coordinated interaction of multiple cell types and molecular processes. However, these processes are not well-defined leading to a paucity of therapeutic approaches to enhance tendon healing. Scleraxis-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2153c3301f7afaa4ea5dba9118b02927
https://doi.org/10.1101/2021.06.02.446663
https://doi.org/10.1101/2021.06.02.446663
Publikováno v:
Curr Rheumatol Rep
PURPOSE OF REVIEW: This review seeks to provide an overview of the role of inflammation and metabolism in tendon cell function, tendinopathy, and tendon healing. We have summarized the state of knowledge in both tendon and enthesis. RECENT FINDINGS:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32d37e0f41fcd1c1432f68b34a78553
https://pubmed.ncbi.nlm.nih.gov/33569739
https://pubmed.ncbi.nlm.nih.gov/33569739
Autor:
Jessica E. Ackerman, Marlin Myers, Justin Cobb, Anne E. C. Nichols, Alayna E. Loiselle, Valentina Studentsova, Emma Knapp, Katherine T. Best, Hani A. Awad
Publikováno v:
J Orthop Res
The use of tamoxifen-inducible models of Cre recombinase in the tendon field is rapidly expanding, resulting in an enhanced understanding of tendon homeostasis and healing. However, the effects of tamoxifen on the tendon are not well-defined, which i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b753f71be08413b905f71098dbf1aa
https://pubmed.ncbi.nlm.nih.gov/32485026
https://pubmed.ncbi.nlm.nih.gov/32485026
Publikováno v:
Journal of Orthopaedic Research. 35:2716-2724
Aging is an important factor in disrupted homeostasis of many tissues. While an increased incidence of tendinopathy and tendon rupture are observed with aging, it is unclear whether this is due to progressive changes in tendon cell function and mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ef9dea2de293b72789adc91c513f94
https://doi.org/10.1002/jor.23580
https://doi.org/10.1002/jor.23580
Autor:
Valentina Studentsova, Anne E. C. Nichols, Emma Knapp, Katherine T. Best, Jessica E. Ackerman, Alayna E. Loiselle
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Identification of pro-regenerative approaches to improve tendon healing is critically important as the fibrotic healing response impairs physical function. In the present study we tested the hypothesis that S100a4 haploinsufficiency or inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88df632443bee068c4e6df6254d05077
https://pubmed.ncbi.nlm.nih.gov/31124787
https://pubmed.ncbi.nlm.nih.gov/31124787