Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jessica E Sutherland"'
Autor:
Richard Grondin, Pei Ge, Qingmin Chen, Jessica E Sutherland, Zhiming Zhang, Don M Gash, David K Stiles, Gregory R Stewart, Dinah W Y Sah, William F Kaemmerer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression o
Externí odkaz:
https://doaj.org/article/2560f36a757e4533913335385c14852e
Autor:
Garvin Warner, Wendell P Davis, Amy Chan, Jessica E. Sutherland, Jason A. Gilbert, Julia Hettinger
Publikováno v:
Nucleic Acid Therapeutics
Revusiran is a 1st-generation short interfering RNA targeting transthyretin conjugated to an N-acetylgalactosamine ligand to facilitate delivery to hepatocytes via uptake by the asialoglycoprotein receptors. Revusiran, in development for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e637ef54500d1abd7c76819946102d
http://europepmc.org/articles/PMC6987735
http://europepmc.org/articles/PMC6987735
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia I. Anglero-Rodriguez, Lan T. H. Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature biotechnology. 40(10)
Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a036125a57dba90192959ce807480ec6
https://pubmed.ncbi.nlm.nih.gov/35654979
https://pubmed.ncbi.nlm.nih.gov/35654979
Publikováno v:
Criminal Justice and Behavior. 47:187-207
Group-perpetrated crime often involves leaders and followers, but it is not currently understood how peer groups form around leaders during a criminal incident. Impression formation research has shown that specific facial cues are associated with lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb2b992f25b4eea6f5c8e333c9009e8
https://doi.org/10.1177/0093854819889645
https://doi.org/10.1177/0093854819889645
Autor:
Krishna Aluri, Laura Sepp-Lorenzino, Christopher R. Brown, Kevin Fitzgerald, Akin Akinc, Martin Maier, Lauren Blair, Peter F Smith, Ju Liu, Jing Li, Ramesh Indrakanti, Biplab Das, Xiumin Liu, Ivan Zlatev, Scott A Barros, Kallanthottathil G. Rajeev, Yongfeng Jiang, Saket Agarwal, Akshay Vaishnaw, Chris Tran, Klaus Charisse, Jingxuan Liu, Muthiah Manoharan, Shigeo Matsuda, Jayaprakash K. Nair, Jessica E. Sutherland, Tracy Zimmermann, Yuanxin Xu, Jing-Tao Wu, Wendell P Davis, Xuemei Zhang, Maja M. Janas, Vasant Jadhav, Mark K Schlegel
Publikováno v:
Nucleic Acids Research
For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone are frequently used to confer drug-like properties. Because 2′-deoxy-2′-fluoro (2′-F) nucleotides are not known to occur naturally, their safety profile wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3324d6db543ac6effbceb9279407203c
https://doi.org/10.1093/nar/gkz140
https://doi.org/10.1093/nar/gkz140
Autor:
Jessica E. Sutherland
Peer passengers are a significant risk factor for young drivers experiencing collisions and other adverse driving outcomes. A number of studies have tested the effect of peer passengers on driving behaviour, but few have manipulated contextual variab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31781546381fff5f31c94ccadec9462b
https://doi.org/10.32920/ryerson.14654763.v1
https://doi.org/10.32920/ryerson.14654763.v1
Publikováno v:
The Legacy of Racism for Children
It is important to consider the potential effects of race, ethnicity, and culture (REC) on how children experience and disclose childhood sexual abuse, and how their disclosures are received by caregivers and state institutions. This chapter reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef2efb003f37b15132970676b9c860a
https://doi.org/10.1093/med-psych/9780190056742.003.0004
https://doi.org/10.1093/med-psych/9780190056742.003.0004
Publikováno v:
Memory and Sexual Misconduct ISBN: 9780429027857
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4ccf72533843147e9e5eb89f855d7b
https://doi.org/10.4324/9780429027857-3
https://doi.org/10.4324/9780429027857-3
Autor:
Natalie D. Keirstead, Garvin Warner, Carole E. Harbison, Brenda Carito, Akshay Vaishnaw, Jessica E. Sutherland, Victoria K. Perry, Maja M. Janas
Publikováno v:
Toxicologic Pathology
Short interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) are the most clinically advanced oligonucleotide-based platforms. A number of N-acetylgalactosamine (GalNAc)-conjugated siRNAs (GalNAc-siRNAs), also referred to as RNA interference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0593c7bf9b2eef2f839d75a0a9f2b11
http://europepmc.org/articles/PMC6249674
http://europepmc.org/articles/PMC6249674