Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jessica E, Friedman"'
Autor:
Ashley Maillet, Fei Liu, Chao Fang, Jinxing Li, Neil Kubica, Lars Kolster Petersen, Donovan N. Chin, Nils Jakob Vest Hansen, Luis A. Barrera, Jenifer B Kaplan, Herschel Mukherjee, Gnanasambandam Kumaravel, J Craig Blain, Lee E Vandivier, Jessica E. Friedman, Allan Beck Christensen, David M. Chenoweth, Jennifer C. Petter
Publikováno v:
ACS Chemical Biology. 15:2374-2381
RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of methods for the analysis of small molecule-RNA interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7520d11f7303715e89e8764fd08c5649
https://doi.org/10.1021/acschembio.0c00357
https://doi.org/10.1021/acschembio.0c00357
Autor:
Robert M. Arduini, Mary Beth Carter, Wen-Cherng Lee, Feng Shan, Xiamei Zhang, Juswinder Singh, Jessica E. Friedman, H.-Kam Cheung, Alan Gill, Mark Cornebise, Harry Sweigard, Donald Costa, Kai Fu, Michael J. Choi, Scott Bowes, P. Ann Boriack-Sjodin, Serene Josiah, Dongyu Sun, Michael J. Corbley, Claudio Chuaqui, Miki N. Newman, Jonathan N. Mead, Lihong Sun, James L. Papadatos, Leona E. Ling, Xin Zhang, Frank Lutterodt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:665-671
Objective— TGF-β plays a significant role in vascular injury-induced stenosis. This study evaluates the efficacy of a novel, small molecule inhibitor of ALK5/ALK4 kinase, in the rat carotid injury model of vascular fibrosis. Methods and Results—
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0432a527297b30567075fe66b68c2c0f
https://doi.org/10.1161/atvbaha.107.158030
https://doi.org/10.1161/atvbaha.107.158030
Autor:
Graham K. Farrington, Jessica E. Friedman, Joshua C. Yoburn, Alexey Lugovskoy, William Michael Flanagan, Stephan K. Miller, Brian C. Cunningham, Amy D. Fung, Adrian Whitty, Molly M. He, Jun Wang, Annemarie Stroustrup Smith, Mark T. Cancilla, John Eldredge, Leslie A. Cruz, Johan D. Oslob, Teresa G. Cachero, Andrew C. Braisted, Eric S. Day, Ingrid C. Choong
Publikováno v:
Science. 310:1022-1025
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α activity in biochemical and cell-based assays with median inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ce3328b91c59024e2eaf119ff3ef0
https://doi.org/10.1126/science.1116304
https://doi.org/10.1126/science.1116304
Autor:
Edward Yin-Shiang Lin, Donovan Chin, Jessica E. Friedman, Daniel Scott, Laura Silvian, Kevin Guckian
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(19)
A series of meta-substituted anilines were designed and synthesized to inhibit the interaction of LFA-1 with ICAM for the treatment of autoimmune disease. Design of these molecules was performed by utilizing a co-crystal structure for structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661cba27b885b898cab2ad38d31f5741
https://pubmed.ncbi.nlm.nih.gov/18778938
https://pubmed.ncbi.nlm.nih.gov/18778938
Autor:
Kevin Guckian, Herman W. T. van Vlijmen, Daniel Scott, Laura Silvian, Jessica E. Friedman, P. Ann Boriack-Sjodin, Donovan Chin, Edward Yin-Shiang Lin
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(19)
LFA-1 ICAM inhibitors based on ortho- and meta-phenol templates were designed and synthesized by Mitsunobu chemistry. The selection of targets was guided by X-ray co-crystal data, and led to compounds which showed an up to 30-fold increase in potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0655819fe7bb7e368dd74b326708fe82
https://pubmed.ncbi.nlm.nih.gov/18783948
https://pubmed.ncbi.nlm.nih.gov/18783948
Autor:
Zhan Deng, Jessica E. Friedman, Claudio Chuaqui, Juswinder Singh, Wen-Cherng Lee, Jason Donnelly, Serene Josiah, Dongyu Sun, Donovan N. Chin, Gretchen Hankins, Patrick Cullen, Scott Bowes
Publikováno v:
Chemical biologydrug design. 67(6)
Lead identification by high-throughput screening of large compound libraries has been supplemented with virtual screening and focused compound libraries. To complement existing approaches for lead identification at Biogen Idec, a kinase-focused compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb53604321ac4457846e57b52737a4e9
https://pubmed.ncbi.nlm.nih.gov/16882313
https://pubmed.ncbi.nlm.nih.gov/16882313
Publikováno v:
The Journal of biological chemistry. 281(5)
The enzyme responsible for iodide salvage in the thyroid, iodotyrosine deiodinase, was solubilized from porcine thyroid microsomes by limited proteolysis with trypsin. The resulting protein retained deiodinase activity and was purified using anion ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da98153ad0d4f125d1a7850df007330
https://pubmed.ncbi.nlm.nih.gov/16316988
https://pubmed.ncbi.nlm.nih.gov/16316988
Autor:
Molly M, He, Annemarie Stroustrup, Smith, Johan D, Oslob, William M, Flanagan, Andrew C, Braisted, Adrian, Whitty, Mark T, Cancilla, Jun, Wang, Alexey A, Lugovskoy, Josh C, Yoburn, Amy D, Fung, Graham, Farrington, John K, Eldredge, Eric S, Day, Leslie A, Cruz, Teresa G, Cachero, Stephan K, Miller, Jessica E, Friedman, Ingrid C, Choong, Brian C, Cunningham
Publikováno v:
Science (New York, N.Y.). 310(5750)
We have identified a small-molecule inhibitor of tumor necrosis factor alpha (TNF-alpha) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-alpha activity in biochemical and cell-based assays with med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::896527c8737cc4d728d7f4577b06518d
https://pubmed.ncbi.nlm.nih.gov/16284179
https://pubmed.ncbi.nlm.nih.gov/16284179
Autor:
Jessica E. Friedman, Teresa G. Cachero, Eric S. Day, Lihe Su, Laura Silvian, Kathy Strauch, Gerald W. Shipps, Brian T. Cunningham, Amy D. Fung, Adrian Whitty, Gnanasambandam Kumaravel, Lihong Sun, Zhongli Zheng, Fang Qian
Publikováno v:
ACS Chemical Biology. 6:761-761
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3637a58c508f11f876eec9bf4c54f312
https://doi.org/10.1021/cb200195p
https://doi.org/10.1021/cb200195p
Publikováno v:
Journal of the American Chemical Society. 121:4722-4723
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfce749efda9dbc53066fe220eb6a920
https://doi.org/10.1021/ja990693n
https://doi.org/10.1021/ja990693n