Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jessica E, Chukwu"'
Autor:
Erin E. Congdon, Jessica E. Chukwu, Dov B. Shamir, Jingjing Deng, Devyani Ujla, Hameetha B.R. Sait, Thomas A. Neubert, Xiang-Peng Kong, Einar M. Sigurdsson
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 157-173 (2019)
Background: Bringing antibodies from pre-clinical studies to human trials requires humanization, but this process may alter properties that are crucial for efficacy. Since pathological tau protein is primarily intraneuronal in Alzheimer's disease, th
Externí odkaz:
https://doaj.org/article/be5e77a5ea40444d949da97a0e989c9e
Publikováno v:
mAbs. 11(3)
Targeting tau with immunotherapies is currently the most common approach taken in clinical trials of patients with Alzheimer’s disease. The most prominent pathological feature of tau is its hyperphosphorylation, which may cause the protein to aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ca81c98a5f01ef878b7a75699ab160f
https://pubmed.ncbi.nlm.nih.gov/30794086
https://pubmed.ncbi.nlm.nih.gov/30794086
Autor:
Jessica E. Chukwu, Hameetha B.R. Sait, Einar M. Sigurdsson, Xiang-Peng Kong, Erin E. Congdon, Jingjing Deng, Dov B. Shamir, Thomas A. Neubert, Devyani Ujla
Publikováno v:
EBioMedicine. 42
Background Bringing antibodies from pre-clinical studies to human trials requires humanization, but this process may alter properties that are crucial for efficacy. Since pathological tau protein is primarily intraneuronal in Alzheimer's disease, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063766a6c0a9a6758d081effba822ea6
https://pubmed.ncbi.nlm.nih.gov/30910484
https://pubmed.ncbi.nlm.nih.gov/30910484
Autor:
Einar M. Sigurdsson, Xiang-Peng Kong, Christiane Volbracht, Jessica E. Chukwu, Jan Torleif Pedersen, Lars Østergaard Pedersen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Tau antibodies have shown therapeutic potential for Alzheimer’s disease and several are in clinical trials. As a microtubule-associated protein, tau relies on dynamic phosphorylation for its normal functions. In tauopathies, it becomes hyperphospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afc1d8dad00a388972873e35adf75f3
https://pubmed.ncbi.nlm.nih.gov/29670132
https://pubmed.ncbi.nlm.nih.gov/29670132