Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jessica Duprez"'
Autor:
Jessica Duprez, Kristen Kalbfleisch, Sasmit Deshmukh, Jessie Payne, Manjit Haer, Wayne Williams, Ibrahim Durowoju, Marina Kirkitadze
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 439-447 (2021)
Purpose: The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods: Several analytical tools including nanoDSF, FTIR, an
Externí odkaz:
https://doaj.org/article/66d02d0a692647a7818df298c6e5436d
Autor:
Kristen Kalbfleisch, Sasmit Deshmukh, Carmen Mei, Moriam Ore, Wayne Williams, Ibrahim Durowoju, Jessica Duprez, Sylvie Morin, Bruce Carpick, Marina Kirkitadze
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 14-20 (2019)
Purpose: The goal of this study is to set an empirical baseline to map the structure-function relation of the antigens from the commercialized vaccine products. Methods: To study the structural changes of protein antigens after adsorption several ana
Externí odkaz:
https://doaj.org/article/59cb11c9209845ce934473361a9087cc
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46831 (2012)
AIM/HYPOTHESIS:Rat pancreatic islet cell apoptosis is minimal after prolonged culture in 10 mmol/l glucose (G10), largely increased in 5 mmol/l glucose (G5) and moderately increased in 30 mmol/l glucose (G30). This glucose-dependent asymmetric V-shap
Externí odkaz:
https://doaj.org/article/3f64aa7fdc434f53955578c571c3f33a
Autor:
Steven W Lindsay, Thomas C Lindsay, Jessica Duprez, Martin J R Hall, Brenda A Kwambana, Musa Jawara, Ikumapayi U Nurudeen, Neneh Sallah, Nigel Wyatt, Umberto D'Alessandro, Margaret Pinder, Martin Antonio
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1895 (2012)
BACKGROUND:Chrysomya spp are common blowflies in Africa, Asia and parts of South America and some species can reproduce in prodigious numbers in pit latrines. Because of their strong association with human feces and their synanthropic nature, we exam
Externí odkaz:
https://doaj.org/article/d850f024997848acaec6554afd15d1b4
Autor:
Sasmit S. Deshmukh, Wayne Williams, Jessie Rose Payne, Manjit Haer, Kristen Kalbfleisch, Ibrahim Durowoju, Marina Kirkitadze, Jessica Duprez
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 439-447 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Purpose The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods Several analytical tools inclu
Purpose The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods Several analytical tools inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735e6521a035760843cac5af0c24fbbe
http://www.sciencedirect.com/science/article/pii/S2001037020305481
http://www.sciencedirect.com/science/article/pii/S2001037020305481
Autor:
Derek J. Wilson, Stephen Li, Salvador F. Ausar, Thomas Bertrand, Jessica Duprez, Roger H. Brookes, Alexey Rak, D. Andrew James, Artur Pedyczak, Shaolong Zhu, Valerie Steier, Anthony Sheung, Michael X Cohen
Publikováno v:
Communications Biology
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein structure and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c21e5acfc882add69441d72d08636b
http://europepmc.org/articles/PMC7406505
http://europepmc.org/articles/PMC7406505
Autor:
Kristen Kalbfleisch, Wayne Williams, Jessica Duprez, Bruce Carpick, Ibrahim Durowoju, Marina Kirkitadze, Moriam Ore, Sasmit S. Deshmukh, Sylvie Morin, Carmen Mei
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 14-20 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 14-20 (2019)
Purpose The goal of this study is to set an empirical baseline to map the structure-function relation of the antigens from the commercialized vaccine products. Methods To study the structural changes of protein antigens after adsorption several analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a83198cc939aa5e6ebfdb2610bac5a
http://europepmc.org/articles/PMC6297905
http://europepmc.org/articles/PMC6297905
Autor:
Jessica Duprez, Stephen Li, Roger H. Brookes, Michael S. Cohen, Derek J. Wilson, D. Andrew James
Publikováno v:
Journal of Immunological Methods. 495:113083
The ability to measure immunomodulatory effects of a vaccine is crucial for novel vaccine design. While traditional animal models have been effective, a better understanding of the response in humans to new vaccines in pre-clinical development is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7063a480f5905bdcf140ab6c1df562d
https://doi.org/10.1016/j.jim.2021.113083
https://doi.org/10.1016/j.jim.2021.113083
Autor:
Carmen Mei, Moriam Ore, Sasmit S. Deshmukh, Joan Bevilacqua, Ibrahim Durowoju, Marina Kirkitadze, Wayne Williams, Jessica Duprez, Bruce Carpick, Kristen Kalbfleisch, Sylvie Morin
1) Background: Traditionally, complex biological products such as vaccines presented unique challenges to implementation of even rudimentary characterization packages; thus, the product was defined almost exclusively by its manufacturing process. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e90bd6e977986e038b3a12769f8ed2
https://doi.org/10.20944/preprints201808.0284.v1
https://doi.org/10.20944/preprints201808.0284.v1
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 309:E632-E639
In rat pancreatic islets, β-cell gene expression, survival, and subsequent acute glucose stimulation of insulin secretion (GSIS) are optimally preserved by prolonged culture at 10 mM glucose (G10) and markedly altered by culture at G5 or G30. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b532b2751a19b942a330da8a6e00f9
https://doi.org/10.1152/ajpendo.00154.2015
https://doi.org/10.1152/ajpendo.00154.2015