Výsledky vyhledávání - "Jessica Dickens"

Abstract 471: Reference materials for tumor mutational burden transcriptome profiling

Autor: Jessica Dickens, Yves Konigshofer, Matthew G. Butler, Bharathi Anekella

Publikováno v: Cancer Research. 81:471-471

Immune Checkpoint Inhibitor (ICI) therapies continue to revolutionize treatment of advanced malignancies. However, identification of individuals who respond to ICI treatment remains challenging. Along with programmed death ligand 1(PD-L1 aka CD274) e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecc4314901d9886f39e472e795794de2
https://doi.org/10.1158/1538-7445.am2021-471

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Abstract 2232: Optimizing Performance of Whole Transcriptome RNA-Seq Reference

Autor: Jessica Dickens, Rajeswari Vemula, Matthew G. Butler, Catherine Huang, Bharathi Anekella, Omoshile Clement, Yves Konigshofer

Publikováno v: Cancer Research. 81:2232-2232

Purpose: Whole transcriptome RNA-sequencing (RNA-Seq) has emerged as one of the most effective methods for detection of genomic rearrangements in cancer. Enrichment for poly(A) + RNA as part of library preparation is a standard method to select for m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fa964ca0c93fd9e8c9ee43c933c31ad
https://doi.org/10.1158/1538-7445.am2021-2232

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Abstract 4315: NGS-based reference materials for fusion and somatic variant detection in myeloid cancers

Autor: Praveena Kamineni, Ram Santhanam, Jessica Dickens, Bharathi Anekella, Omoshile Clement, Dan Brudzewsky, Catherine Huang, Farol L. Tomson

Publikováno v: Cancer Research. 80:4315-4315

The large range of genetic aberrations and genes involved Myeloid malignancies, clonal diseases of hematopoietic progenitor cells which can lead to accumulation of immature blast cells in the bone marrow and peripheral blood, make Next Generation Seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06311e07c3b386080a4de155b3336c43
https://doi.org/10.1158/1538-7445.am2020-4315

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Abstract 1978: Reference materials for measurable residual disease (MRD) monitoring

Autor: Bharathi Anekella, Russell Garlick, Omoshile Clement, Dan Brudzewsky, Jessica Dickens, Yves Konigshofer, Andrew Anfora, Matthew G. Butler

Publikováno v: Cancer Research. 80:1978-1978

Here we describe reference materials for measurable residual disease (MRD) assay design and validation as well as initial data from testing. The analytical validation of liquid biopsy-based assays that attempt to monitor for the disappearance and ree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d14a85b9e5b906465d00d899b40e2db
https://doi.org/10.1158/1538-7445.am2020-1978

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Abstract 5569: Donor-derived circulating cell-free DNA (ccfDNA) reference materials for concordance studies

Autor: Bharathi Anekella, Matthew G. Butler, Jessica Dickens, Russell Garlick, Yves Konigshofer, Karl G. Sylvester, Katherine Bianco

Publikováno v: Cancer Research. 78:5569-5569

The limited quantities of ccfDNA in plasma can make it difficult to assess the sensitivities and specificities of circulating tumor DNA (ctDNA) assays because there is often insufficient material to confirm the presence or absence of particular mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a9d9fb05834c3fbf23a57e0d1e65a5f
https://doi.org/10.1158/1538-7445.am2018-5569

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Abstract 4540: Development of well characterized breast, lung, and brain cancer copy number variation reference materials

Autor: Jessica Dickens, Yves Konigshofer, Bharathi Anekella, Catherine Huang, Dana J. Ruminski Lowe

Publikováno v: Cancer Research. 78:4540-4540

Introduction: Copy number variation (CNV), including gene amplification and deletion, can be a key driver of oncogenesis. Pathogenic CNVs are often associated with unfavorable prognosis and drug resistance, therefore detection of these types of genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7a74e51598839976d7df7fefceee7c1
https://doi.org/10.1158/1538-7445.am2018-4540

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Abstract 738: Highly multiplexed and precisely calibrated reference materials for copy number variation detection

Autor: Yves Konigshofer, Bharathi Anekella, Jessica Dickens, Catherine Huang

Publikováno v: Cancer Research. 77:738-738

Introduction: Genomic instability is a hallmark of cancer, and copy number variation (CNV), including gene duplication and deletion, can be a key driver of oncogenesis. Detection of CNV is needed for personalized treatment, and may involve microarray

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6f6e3c6e14962d9320ea0468f5d5488
https://doi.org/10.1158/1538-7445.am2017-738

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