Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jessica D Lang"'
Autor:
Olivia E Harwood, Lea M Matschke, Ryan V Moriarty, Alexis J Balgeman, Abigail J Weaver, Amy L Ellis-Connell, Andrea M Weiler, Lee C Winchester, Courtney V Fletcher, Thomas C Friedrich, Brandon F Keele, David H O'Connor, Jessica D Lang, Matthew R Reynolds, Shelby L O'Connor
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011676 (2023)
Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-haplomatched cohort of MHC-M3+ SIVmac239+ Mauritian cynomolgus ma
Externí odkaz:
https://doaj.org/article/4923447812844a0a8eb8bb1afde9858e
Autor:
Krystal Ann Orlando, Amber K Douglas, Aierken Abudu, Yemin Wang, Basile Tessier-Cloutier, Weiping Su, Alec Peters, Larry S Sherman, Rayvon Moore, Vinh Nguyen, Gian Luca Negri, Shane Colborne, Gregg B Morin, Friedrich Kommoss, Jessica D Lang, William PD Hendricks, Elizabeth A Raupach, Patrick Pirrotte, David G Huntsman, Jeffrey M Trent, Joel S Parker, Jesse R Raab, Bernard E Weissman
Publikováno v:
eLife, Vol 9 (2020)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling
Externí odkaz:
https://doaj.org/article/42b0954003194a36bc670b2a11181aaf
Autor:
Rebecca F. Halperin, Apurva Hegde, Jessica D. Lang, Elizabeth A. Raupach, C4RCD Research Group, Christophe Legendre, Winnie S. Liang, Patricia M. LoRusso, Aleksandar Sekulic, Jeffrey A. Sosman, Jeffrey M. Trent, Sampathkumar Rangasamy, Patrick Pirrotte, Nicholas J. Schork
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The robust detection of disease-associated splice events from RNAseq data is challenging due to the potential confounding effect of gene expression levels and the often limited number of patients with relevant RNAseq data. Here we present a
Externí odkaz:
https://doaj.org/article/a3220a92cf2645288aad59ed2f183636
Autor:
Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P. D. Hendricks, Virginia Espina, Joyce O'Shaughnessy
BACKGROUND A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-117 (PI3Kα inhibitor), is hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998612c7cdd34111d380c535d7596fb1
https://doi.org/10.21203/rs.3.rs-2864312/v1
https://doi.org/10.21203/rs.3.rs-2864312/v1
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Fig.S1 shows that SCCOHT cells are sensitive to HDAC inhibition. Fig. S2 shows that SCCOHT cells are sensitive to HDAC inhibition or depletion. Fig.S3 shows that SMARCA4/A2 dual deficiency is not associated with hypersensitivity to HDAC inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2396ee9de14b76e5d7859ed9f267bb73
https://doi.org/10.1158/1535-7163.22510063.v1
https://doi.org/10.1158/1535-7163.22510063.v1
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but extremely lethal malignancy that mainly impacts young women. SCCOHT is characterized by a diploid genome with loss of SMARCA4 and lack of SMARCA2 expression, two mutually ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37952b52d6236e3e9efd5a279b26f72e
https://doi.org/10.1158/1535-7163.c.6539491
https://doi.org/10.1158/1535-7163.c.6539491
Supplementary Figure from The COX-2–PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec7ff587cd20d2291016ccdedc63385
https://doi.org/10.1158/1940-6207.22534873
https://doi.org/10.1158/1940-6207.22534873
Autor:
David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent, Gregg B. Morin, T. Michael Underhill, Ralf Hass, Anthony N. Karnezis, Marcel B. Bally, William P.D. Hendricks, Jessica D. Lang, Krystal A. Orlando, Nancy Dos Santos, Chae Young Shin, Galen Lambert, Shane Colborne, Shary Yuting Chen, Yemin Wang
Table S1 shows the cell viability inhibitory rate (%) in SCCOHT cell lines vs other cell lines in the epigenetic drug screen. Table S2 shows the effects of Quisinostat on the proteome of BIN67 cells after treatment for 24 or 72 hours. Table S3 shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43304537c45779fc06e18054f0e3bb95
https://doi.org/10.1158/1535-7163.22510060.v1
https://doi.org/10.1158/1535-7163.22510060.v1
The mechanisms underlying the regulation of a checkpoint receptor, PD-1, in tumor-infiltrating immune cells during the development of colorectal cancer are not fully understood. Here we demonstrate that COX-2–derived PGE2, an inflammatory mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d97c414ecfac0e4e3e6ec0cab1817d
https://doi.org/10.1158/1940-6207.c.6547681.v1
https://doi.org/10.1158/1940-6207.c.6547681.v1
Autor:
Jeffrey M. Trent, David G. Huntsman, Bernard E. Weissman, Praveen Nair, Barbara C. Vanderhyden, Ralf Hass, Aleksandar Sekulic, Anthony N. Karnezis, Yemin Wang, Michael B. Major, Emily M. Cousins, Victoria L. Zismann, Salvatore J. Facista, Megan Washington, Winnie S. Liang, Nanyun Tang, Chris Sereduk, Elizabeth A. Raupach, Patrick Pirrotte, Ritin Sharma, Pilar Ramos, Jeffrey Kiefer, Hongwei Yin, Krystal A. Orlando, William P.D. Hendricks, Jessica D. Lang
IC50 summary of validated drug hits in SCCOHT cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38616ea70cb460eabed4bb61f65d7345
https://doi.org/10.1158/1078-0432.22464359.v1
https://doi.org/10.1158/1078-0432.22464359.v1