Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jessica Cunningham"'
Publikováno v:
eLife, Vol 11 (2022)
Background: Abiraterone acetate is an effective treatment for metastatic castrate-resistant prostate cancer (mCRPC), but evolution of resistance inevitably leads to progression. We present a pilot study in which abiraterone dosing is guided by evolut
Externí odkaz:
https://doaj.org/article/21124a6c2ed441e89943554ccae47f87
Publikováno v:
Harvard Data Science Review (2022)
Externí odkaz:
https://doaj.org/article/017f885c83974080add8c35b1979876d
Autor:
Kathleen Hurley, Sinead O’Brien, Ciaran Halleran, Derina Byrne, Erin Foley, Jessica Cunningham, Fionnuala Hoctor, Laura J. Sahm
Publikováno v:
Pharmacy, Vol 11, Iss 1, p 23 (2023)
People who are diagnosed with treatment resistant schizophrenia (TRS) are likely to have clozapine as a therapeutic management option. There is a high prevalence of metabolic syndrome in patients receiving clozapine. To mitigate against this, monitor
Externí odkaz:
https://doaj.org/article/2723c7a49f66409c9e1234c38d50f260
Autor:
Jessica Cunningham, Frank Thuijsman, Ralf Peeters, Yannick Viossat, Joel Brown, Robert Gatenby, Kateřina Staňková
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243386 (2020)
In the absence of curative therapies, treatment of metastatic castrate-resistant prostate cancer (mCRPC) using currently available drugs can be improved by integrating evolutionary principles that govern proliferation of resistant subpopulations into
Externí odkaz:
https://doaj.org/article/9a498e2f3f9646fc8c36bc3b3e54ebf0
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007372 (2019)
Intracellular thermometry has recently demonstrated temperatures in the nucleus, mitochondria, and centrosome to be significantly higher than those of the cytoplasm and cell membrane. This local thermogenesis and the resulting temperature gradient co
Externí odkaz:
https://doaj.org/article/d247cf64f36d48eb8361baab46da1282
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42425 (2012)
The cell-extracellular matrix (ECM) interaction plays an essential role in maintaining tissue shapes and regulates cell behaviors such as cell adhesion, differentiation and proliferation. The mechanism by which the ECM influences the cell cycle in vi
Externí odkaz:
https://doaj.org/article/fe6ee682e65b4ff3906d7ebd1d9e69d7
Autor:
Jessica Cunningham, Veronica Estrella, Mark Lloyd, Robert Gillies, B Roy Frieden, Robert Gatenby
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36894 (2012)
Mammalian cell function requires timely and accurate transmission of information from the cell membrane (CM) to the nucleus (N). These pathways have been intensively investigated and many critical components and interactions have been identified. How
Externí odkaz:
https://doaj.org/article/a74f0fbb8e664c07a2c3cafb75d5a059
Publikováno v:
Nutrition Reviews. 80:329-350
Context Cardiometabolic diseases are leading causes of death and morbidity. Aging increases the risk of disease development. Diet has protective and causal effects on cardiometabolic health. Objective To consolidate the current evidence on the short-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6aae76298075e3592aa53e6c0049732
https://doi.org/10.1093/nutrit/nuab032
https://doi.org/10.1093/nutrit/nuab032
Autor:
Audrey R. Freischel, Jamie K. Teer, Kimberly Luddy, Jessica Cunningham, Yael Artzy-Randrup, Tamir Epstein, Kenneth Y. Tsai, Anders Berglund, John L. Cleveland, Robert J. Gillies, Joel S. Brown, Robert A. Gatenby
Publikováno v:
Cancers; Volume 15; Issue 1; Pages: 18
We identify critical conserved and mutated genes through a theoretical model linking a gene’s fitness contribution to its observed mutational frequency in a clinical cohort. “Passenger” gene mutations do not alter fitness and have mutational fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8c2c5722e0ba6569caf078b42fc535
