Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jessica C. Langer"'
Publikováno v:
Blood. 104:374-379
The number of bone marrow hematopoietic stem and progenitor cells as defined by the lineage(-), Sca1(++), c-kit(+) (LSK) phenotype and their proliferative capacity in vitro are subject to quantitative genetic variation, and several quantitative trait
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e44e8e8be9485e41f5f53e642d1bab1
https://doi.org/10.1182/blood-2003-12-4304
https://doi.org/10.1182/blood-2003-12-4304
Publikováno v:
The Journal of Experimental Medicine
Elucidation of pathways involved in mouse strain-dependent variation in the hematopoietic stem cell (HSC) compartment may reveal novel mechanisms relevant in vivo. Here, we demonstrate genetically determined variation in the proliferation of lin-Sca1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041b753c47507b87abebef965adda8e8
https://doi.org/10.1084/jem.20030980
https://doi.org/10.1084/jem.20030980
Autor:
Michael S. Lipkowitz, Jessica C. Langer, Michael W. Ross, Basil Hanss, Mary E. Klotman, Patricia D. Wilson, Gary J. Kurtzman, Paul E. Klotman, Natalie Tulchin
Publikováno v:
Journal of the American Society of Nephrology. 10:1908-1915
There has been an increasing interest recently in the possibility of treating renal diseases using gene therapy. The ability to pursue gene therapy for renal diseases has been limited by the availability of an adequate system for gene delivery to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941d4176d2fc007fd525927b8d285fda
https://doi.org/10.1681/asn.v1091908
https://doi.org/10.1681/asn.v1091908
Autor:
Jessica C. Langer, Joseph F. Pizzolato, Hsin-yi Tang, Kathy Zhao, Maxim Fonarev, James J. Manfredi
Publikováno v:
Journal of Biological Chemistry. 273:29156-29163
The tumor suppressor protein p53 has been implicated in the response of cells to DNA damage. Studies to date have demonstrated a role for p53 in the transcriptional activation of target genes in the cellular response to DNA damage that results in eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf15fc3bda19100a53a173af35205d95
https://doi.org/10.1074/jbc.273.44.29156
https://doi.org/10.1074/jbc.273.44.29156
Autor:
Jessica C. Langer, Natalie Tulchin, Paul E. Klotman, Michael S. Lipkowitz, Leslie A. Bruggeman, Mary E. Klotman, Basil Hanss
Publikováno v:
Nephron Experimental Nephrology. 6:189-194
The human parvovirus adeno-associated virus (AAV), type 2, has a number of features that make it an attractive choice as a vector for gene delivery to the kidney. AAV vectors permit long-term gene expression in vivo by integration into the host genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f65ae847881058f71c3c2abfd77a6bf
https://doi.org/10.1159/000020522
https://doi.org/10.1159/000020522
Autor:
Margaret Hsieh, Jessica C. Langer, Jacqueline Fleming, Mary B. Breckenridge, Caryn Borger, Kevan A. McCarten-Gibbs, Denise H. DeNoble, Deena R. Zimmerman
Publikováno v:
Current Problems in Pediatrics. 27:293-303
Study objective: To determine the rate of repeat visits among children cared for in a general emergency department and associated demographic and clinical variables. Methods: We carried out a chart review of patients seen in the ED of a general hospi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f573960886551c6dc9cad072e33446
https://doi.org/10.1016/s0045-9380(97)80020-5
https://doi.org/10.1016/s0045-9380(97)80020-5
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 61(6)
We discovered a novel population of gammadelta T cells in the mouse that accumulates with age in hematopoietic organs, but not in epithelia. These cells are CD25low (an unusual phenotype for gammadelta T cells in the mouse); express higher levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4172103de5fc2532a6ebcf0665ee22
https://pubmed.ncbi.nlm.nih.gov/16799138
https://pubmed.ncbi.nlm.nih.gov/16799138
The mechanisms regulating thymic involution are unclear. In inbred mouse strains the rate of thymic involution and the function of the hematopoietic stem cell (HSC) compartment are subject to quantitative genetic variation. We have shown previously t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba09672a3d6956025a93f301cd672ce
https://europepmc.org/articles/PMC1895709/
https://europepmc.org/articles/PMC1895709/
TGF-beta is considered a negative regulator of hemopoietic stem and progenitor cells. We have previously shown that one TGF-beta isoform, TGF-beta2, is, in fact, a positive regulator of murine hemopoietic stem cell function in vivo. In vitro, TGF-bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa2a425ac014ebd08f0d50dc6e59b80
https://lirias.kuleuven.be/handle/123456789/677231
https://lirias.kuleuven.be/handle/123456789/677231
Autor:
Gary Van Zant, Els Henckaerts, Hans-Willem Snoeck, Patricia Rebollo, Hartmut Geiger, Jessica C. Langer
Publikováno v:
Blood. 99(11)
Quantitative trait analysis may shed light on mechanisms regulating hematopoiesis in vivo. Strain-dependent variation existed among C57BL/6 (B6), DBA/2, and BXD recombinant inbred mice in the responsiveness of primitive progenitor cells to the early-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927c32013fabd87808ff834838a37af0
https://pubmed.ncbi.nlm.nih.gov/12010793
https://pubmed.ncbi.nlm.nih.gov/12010793