Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jessica C. Kling"'
Autor:
Thao Thanh Tran, Carmen D. Mathmann, Marcela Gatica-Andrades, Rachel F. Rollo, Melanie Oelker, Johanna K. Ljungberg, Tam T. K. Nguyen, Alina Zamoshnikova, Lalith K. Kummari, Orry J. K. Wyer, Katharine M. Irvine, Javier Melo-Bolívar, Annette Gross, Darren Brown, Jeffrey Y. W. Mak, David P. Fairlie, Karl A. Hansford, Matthew A. Cooper, Rabina Giri, Veronika Schreiber, Shannon R. Joseph, Fiona Simpson, Timothy C. Barnett, Jörgen Johansson, Wendy Dankers, James Harris, Timothy J. Wells, Ronan Kapetanovic, Matthew J. Sweet, Eleanor A. Latomanski, Hayley J. Newton, Romain J. R. Guérillot, Abderrahman Hachani, Timothy P. Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L. Hartland, Bostjan Kobe, Jennifer L. Stow, A. Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C. Kling, Antje Blumenthal
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator Prf
Externí odkaz:
https://doaj.org/article/66dd0ab76b8e4e24a1aee04a59d0cdfa
Autor:
Roma Sinha, Minh Dao Ngo, Stacey Bartlett, Helle Bielefeldt-Ohmann, Sahar Keshvari, Sumaira Z. Hasnain, Meg L. Donovan, Jessica C. Kling, Antje Blumenthal, Chen Chen, Kirsty R. Short, Katharina Ronacher
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Type 2 diabetes (T2D) is a well-known risk factor for tuberculosis (TB), but little is known about pre-diabetes and the relative contribution of impaired glucose tolerance vs. obesity towards susceptibility to TB. Here, we developed a preclinical mod
Externí odkaz:
https://doaj.org/article/93a8341a52db45a48174c27001e6e531
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
It is well-established that aberrant WNT expression and signaling is associated with developmental defects, malignant transformation and carcinogenesis. More recently, WNT ligands have emerged as integral components of host responses to infection but
Externí odkaz:
https://doaj.org/article/6b26a36e39bf4772aabc15714b5c97c4
Autor:
Ulrike Schleicher, Katrin Paduch, Andrea Debus, Stephanie Obermeyer, Till König, Jessica C. Kling, Eliana Ribechini, Diana Dudziak, Dimitrios Mougiakakos, Peter J. Murray, Renato Ostuni, Heinrich Körner, Christian Bogdan
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 1062-1075 (2016)
Neutralization or deletion of tumor necrosis factor (TNF) causes loss of control of intracellular pathogens in mice and humans, but the underlying mechanisms are incompletely understood. Here, we found that TNF antagonized alternative activation of m
Externí odkaz:
https://doaj.org/article/6fad66d1b5b74e94a18ab67af0adf4d1
Autor:
Jessica C. Kling, Margaret A. Jordan, Lauren A. Pitt, Jana Meiners, Thao Thanh-Tran, Le Son Tran, Tam T. K. Nguyen, Deepak Mittal, Rehan Villani, Raymond J. Steptoe, Kiarash Khosrotehrani, Stuart P. Berzins, Alan G. Baxter, Dale I. Godfrey, Antje Blumenthal
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity. Interferon gamma (IFN-γ) and IL-4 are key cytokines rapidly produced by NKT cells upo
Externí odkaz:
https://doaj.org/article/4c72b58f73b64ff4b2d43b728cc74118
Autor:
Meg L. Donovan, Helle Bielefeldt‐Ohmann, Rachel F. Rollo, Stephen J. McPherson, Thomas E. Schultz, Giorgia Mori, Jessica C. Kling, Antje Blumenthal
Publikováno v:
Immunology. 169:13-26
Granulomas are key histopathological features of Mycobacterium tuberculosis (Mtb) infection, with complex roles in pathogen control and dissemination. Thus, understanding drivers and regulators of granuloma formation is important for improving tuberc
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
It is well-established that aberrant WNT expression and signaling is associated with developmental defects, malignant transformation and carcinogenesis. More recently, WNT ligands have emerged as integral components of host responses to infection but
Autor:
Helen Benham, Tam T. K. Nguyen, Dimitrios Vagenas, Jeremy Cohen, Ranjeny Thomas, Bala Venkatesh, Marcela Gatica-Andrades, Jessica C. Kling, Heinrich Körner, Antje Blumenthal
Publikováno v:
Blood Advances. 1:1274-1286
Improved understanding of the molecular mechanisms underlying dysregulated inflammatory responses in severe infection and septic shock is urgently needed to improve patient management and identify new therapeutic opportunities. The WNT signaling path
Autor:
Jessica C. Kling, Antje Blumenthal
Publikováno v:
Journal of Leukocyte Biology. 101:827-840
Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be
Publikováno v:
Frontiers in Microbiology, Vol 6 (2016)
Frontiers in Microbiology
Frontiers in Microbiology
Induction of inducible nitric oxide synthase in mononuclear phagocytes by IFN-γ and innate tumor necrosis factor (TNF) provide the basis for an effective immune response to the intracellular parasite Leishmania (L.) major. In previous experiments, w