Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jessica C. Gaspar"'
Publikováno v:
Molecules, Vol 27, Iss 6, p 2021 (2022)
There is evidence for the involvement of peroxisome proliferator-activated receptors (PPARs) in pain, cognition, and anxiety. However, their role in pain–fear interactions is unknown. The amygdala plays a key role in pain, conditioned fear, and fea
Externí odkaz:
https://doaj.org/article/b2309c9557714a3d8870f659572e81c8
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 610 (2021)
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPARα, PPARβ/δ and PPARγ. Studies suggest that the PPAR signalling system may modulate pain, anxiety and cognition. The a
Externí odkaz:
https://doaj.org/article/aaaf85c6dd284c9ea4fbaa73163adbd1
Publikováno v:
Molecules, Vol 25, Iss 4, p 1007 (2020)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPARα, PPARβ/δ, PPARγ) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear interactions has not yet be
Externí odkaz:
https://doaj.org/article/6d0f367e1e4143ceb7cb26d4fbbbbf40
Autor:
Michelle Roche, David P. Finn, Alvaro Llorente-Berzal, Jessica C. Gaspar, Kieran Rea, Fiona McGowan
Publikováno v:
Neuroscience. 480
The endocannabinoid system within the periaqueductal grey (PAG) has been implicated in fear-conditioned analgesia (FCA), the profound suppression of pain upon re-exposure to a context previously paired with an aversive stimulus. Since the endocannabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606f1e80a09e7074d8dbcf952ea9081a
https://pubmed.ncbi.nlm.nih.gov/34774710
https://pubmed.ncbi.nlm.nih.gov/34774710
Publikováno v:
Molecules
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 1007 (2020)
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 1007 (2020)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPAR&alpha
PPAR&beta
/&delta
PPAR&gamma
) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pa
PPAR&beta
/&delta
PPAR&gamma
) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2854d878180cf85a3067c7d4865a4cac
http://hdl.handle.net/10379/16257
http://hdl.handle.net/10379/16257
Publikováno v:
British Journal of Pharmacology. 176:1421-1442
Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or associated with significant advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa55372a8111105a21b7056ced0cf3f
https://doi.org/10.1111/bph.14339
https://doi.org/10.1111/bph.14339
Autor:
Brendan Harhen, Gemma Mc Laughlin, Bright N. Okine, Jessica C. Gaspar, David P. Finn, Michelle Roche
Publikováno v:
Neuroscience. 443
The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, the present study tested the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ab62d31a11f0db279132a2a554cbd8
https://pubmed.ncbi.nlm.nih.gov/32673629
https://pubmed.ncbi.nlm.nih.gov/32673629
Publikováno v:
Biomedicines
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 610, p 610 (2021)
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 610, p 610 (2021)
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPAR¿, PPARß/¿ and PPAR¿. Studies suggest that the PPAR signalling system may modulate pain, anxiety and cognition. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bf4224d84713239c2a79b4b7a94f99
https://doi.org/10.3390/biomedicines9060610
https://doi.org/10.3390/biomedicines9060610
Autor:
Brendan Harhen, Bright N. Okine, Manish K. Madasu, David P. Finn, Charles Prendergast, Jessica C. Gaspar, Michelle Roche, Fiona McGowan
The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA administration into the anterior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8652e5820c853a07dd2a48a6a1675ee9
http://hdl.handle.net/10379/15083
http://hdl.handle.net/10379/15083
Autor:
Brendan Harhen, Bright N. Okine, Jessica C. Gaspar, Weredeselam M. Olango, Michelle Roche, Manish K. Madasu, David P. Finn
Publikováno v:
Brain research. 1657
The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueducta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed72c216fa51220b3bb8504888a83c09
https://pubmed.ncbi.nlm.nih.gov/27916440
https://pubmed.ncbi.nlm.nih.gov/27916440