Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jessica C. Garbern"'
Autor:
Nivedhitha Velayutham, Jessica C. Garbern, Hannah L. T. Elwell, Zhu Zhuo, Laura Rüland, Farid Elcure Alvarez, Sara Frontini, Yago Rodriguez Carreras, Marie Eichholtz, Elisabeth Ricci‐Blair, Jeanna Y. Shaw, Aldric H. Bouffard, Morgan Sokol, Estela Mancheño Juncosa, Seth Rhoades, Daphne van den Berg, Alexander Kreymerman, Junya Aoyama, Jens Höfflin, Herb Ryan, Shannan Ho Sui, Richard T. Lee
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background Current protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when hiPSC‐C
Externí odkaz:
https://doaj.org/article/0f6ccd0ad57e4a3b9de0de5968e8b89e
Autor:
Jessica C. Garbern, Richard T. Lee
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-25 (2021)
Abstract Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs) inadequately recapitulate complete development and result in PSC-derived cardiomyocytes (PSC-CMs) with an immature or fetal-like phenotype. Embryonic an
Externí odkaz:
https://doaj.org/article/26365eb57d8140289dd56323c91b3762
Autor:
Zuwan Lin, Jessica C. Garbern, Ren Liu, Qiang Li, Estela Mancheño Juncosa, Hannah L.T. Elwell, Morgan Sokol, Junya Aoyama, Undine-Sophie Deumer, Emma Hsiao, Hao Sheng, Richard T. Lee, Jia Liu
Publikováno v:
Science Advances. 9
Clinical translation of stem cell therapies for heart disease requires electrical integration of transplanted cardiomyocytes. Generation of electrically matured human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) is critical for
Autor:
Jessica C. Garbern, Richard T. Lee
Publikováno v:
Dev Cell
Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat heart failure. In the past 20 years, the field of heart regeneration has entered a renaissance period with remarka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d099e21464237405bdeee4985d6625
https://europepmc.org/articles/PMC8896288/
https://europepmc.org/articles/PMC8896288/
Autor:
Guido Krähenbühl, Mohsen Sarikhani, Aishah Ahmed, Jeffrey Conde, Sai Ma, Gabriela O. Escalante, Richard T. Lee, Jason D. Buenrostro, Rebecca Sereda, Jessica C. Garbern
Publikováno v:
Stem Cell Reports
Summary Recent studies suggest that metabolic regulation may improve differentiation of cardiomyocytes derived from induced pluripotent stem cells (iPSCs). AMP-activated protein kinase (AMPK) is a master regulator of metabolic activities. We investig
Autor:
Vassilios J. Bezzerides, Mohsen Sarikhani, Aharon Helman, Kevin Kit Parker, John F. Zimmerman, Aishah Ahmed, Jessica C. Garbern, Gabriela O. Escalante, Sean L. Kim, Rebecca Sereda, Roza Ogurlu, Douglas A. Melton, Alexander Cho, Luke A. MacQueen, Richard T. Lee
Publikováno v:
Circulation
Background: Current differentiation protocols to produce cardiomyocytes from human induced pluripotent stem cells (iPSCs) are capable of generating highly pure cardiomyocyte populations as determined by expression of cardiac troponin T. However, thes
Autor:
Jessica C Garbern, Qiang Li, Ren Liu, Estela Mancheno Juncosa, Zuwan Lin, Hannah L Elwell, Junya Aoyama, Sokol K Morgan, Jia Liu, Richard T Lee
Publikováno v:
Circulation. 144
Clinical translation of stem cell therapies for heart disease is limited by a risk of potentially life-threatening ventricular arrhythmias seen following cardiomyocyte delivery in large animal models. Enhancing cardiomyocyte maturation may reduce thi
Autor:
Jessica C Garbern, Hannah L Elwell, Estela Mancheno Juncosa, Daphne van den Berg, Morgan K Sokol, Richard T Lee
Publikováno v:
Circulation. 144
Directed differentiation of human pluripotent stem cells (PSC) into cardiomyocytes via manipulation of Wnt signaling leads to generation of immature cardiomyocytes, more closely resembling a fetal state. It has become increasingly apparent that metab
Autor:
Rebecca Sereda, Amy J. Wagers, Henk Schoemaker, Ana Vujic, Liming Peng, Amy C. Kristl, Jill M. Goldstein, Vinicius Bassaneze, Elisabeth M Ricci-Blair, Jessica C. Garbern, Richard T. Lee, Ryan G. Walker, Shalender Bhasin
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 317:H201-H212
Administration of active growth differentiation factor 11 (GDF11) to aged mice can reduce cardiac hypertrophy, and low serum levels of GDF11 measured together with the related protein, myostatin (also known as GDF8), predict future morbidity and mort
Autor:
Richard T. Lee, Jessica C. Garbern
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-25 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs) inadequately recapitulate complete development and result in PSC-derived cardiomyocytes (PSC-CMs) with an immature or fetal-like phenotype. Embryonic and fetal d