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pro vyhledávání: '"Jessica C. Boakes"'
Autor:
Jessica C. Boakes, Steven. P. D. Harborne, Jessie T. S. Ngo, Christos Pliotas, Adrian Goldman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human equilibrative nucleoside transporters represent a major pharmaceutical target for cardiac, cancer and viral therapies. Understanding the molecular basis for transport is crucial for the development of improved therapeutics through structure-bas
Externí odkaz:
https://doaj.org/article/f96b77b34352440880f14624b689e698
Autor:
Jessica C. Boakes, Danielle L. Wright, Steven P. D. Harborne, Jannik Strauss, Jacques Boivineau, Veli-Pekka Jaakola, James G. Henderson, Adrian Goldman
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Identifying stabilising variants of membrane protein targets is often required for structure determination. Our new computational pipeline, the Integral Membrane Protein Stability Selector (IMPROvER) provides a rational approach to variant selection