Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jessica B. Zheng"'
Publikováno v:
Journal of Neuroscience. 25:5533-5543
Beta-amyloid precursor protein (APP) is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. Analogy to the Notch protein suggests that A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba29779f6c4ed93abf303e823d7fcf1
https://doi.org/10.1523/jneurosci.4883-04.2005
https://doi.org/10.1523/jneurosci.4883-04.2005
Publikováno v:
Genome Research. 12:1716-1722
Pax6 is an important regulator of transcription in the development of the eye and central nervous system in vertebrates and invertebrates (Quiring et al. 1994). The protein sequence and function of Pax6 are evolutionarily conserved so that murine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96596fe12f08e8e08b4a318c4c5cf050
https://doi.org/10.1101/gr.188302
https://doi.org/10.1101/gr.188302
Publikováno v:
Nucleic Acids Research. 29:4070-4078
PAX6 is a transcription factor that plays a major role in ocular morphogenesis. PAX6 is expressed in the eye, central nervous system and pancreas. Two alternative promoters, P0 and P1, which are differentially regulated during development, drive PAX6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840b16c4f76154f38b321c1736a366c4
https://doi.org/10.1093/nar/29.19.4070
https://doi.org/10.1093/nar/29.19.4070
Publikováno v:
Carcinogenesis. 20:1085-1089
We have used the UvrABC nuclease incision method in combination with ligation-mediated polymerase chain reaction (LMPCR) techniques to map and quantify (+/-)anti-7beta, 8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]-pyrene (BPDE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff35b95549b0fb405ef42639c4fc0719
https://doi.org/10.1093/carcin/20.6.1085
https://doi.org/10.1093/carcin/20.6.1085
Autor:
Joseph J. LoTurco, Jilin Bai, Dennis J. Selkoe, Tracy L. Young-Pearse, Jessica B. Zheng, Rui Chang
Physiological processing of the β-amyloid precursor protein (APP) generates amyloid β-protein, which can assemble into oligomers that mediate synaptic failure in Alzheimer's disease. Two decades of research have led to human trials of compounds tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7d26564cb42d4ccc4fa6a2bb48a023
https://europepmc.org/articles/PMC6673432/
https://europepmc.org/articles/PMC6673432/
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eea2ca27bafd364b3dd0d091cf937d7
https://doi.org/10.1016/j.jalz.2006.05.334
https://doi.org/10.1016/j.jalz.2006.05.334
Autor:
Dora Louard, Dennis J. Selkoe, Frank R. Ervin, Amy Beierschmitt, Timothy J. Seabrook, Melitza Iglesias, Roberta M. Palmour, Edward T. Spooner, Jeanne K. Bloom, Diana Li, Jessica B. Zheng, Jodi F. Leverone, Cynthia A. Lemere
Publikováno v:
The American journal of pathology. 165(1)
Amyloid beta (Abeta) protein immunotherapy lowers cerebral Abeta and improves cognition in mouse models of Alzheimer's disease (AD). Here we show that Caribbean vervet monkeys (Chlorocebus aethiops, SK) develop cerebral Abeta plaques with aging and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65576d3bb3aefa8954be076b2840799f
https://pubmed.ncbi.nlm.nih.gov/15215183
https://pubmed.ncbi.nlm.nih.gov/15215183
Autor:
Annie Pao, Moon-shong Tang, Gerd P. Pfeifer, Jessica B. Zheng, Mikhail F. Denissenko, Haiying Li, James X. Chen, Yi Zheng, Wenwei Hu, Zhaohui Feng
Publikováno v:
International journal of hygiene and environmental health. 205(1-2)
Genomic injury induced by environmental carcinogens, such as polycyclic aromatic hydrocarbons and aromatic amines, is the initial step that can trigger mutagenesis and carcinogenesis. In addition to the physico-chemical property of DNA damaging agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ac6965f82fd0a1eb5b7064c0013b84
https://pubmed.ncbi.nlm.nih.gov/12018002
https://pubmed.ncbi.nlm.nih.gov/12018002
Publikováno v:
The Journal of biological chemistry. 276(43)
The beta-amyloid precursor protein (APP) is a ubiquitous receptor-like molecule without a known function. However, the recent recognition that APP and Notch undergo highly similar proteolytic processing has suggested a potential signaling function fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85227528aef7657650b50010242a5b99
https://pubmed.ncbi.nlm.nih.gov/11544248
https://pubmed.ncbi.nlm.nih.gov/11544248
Publikováno v:
Gene. 245(2)
Pax-6 encodes a transcription factor that is important in the development of eye and CNS. Identification of Pax-6 target genes is crucial for understanding the gene regulatory network in these developmental processes. Using an in-vitro approach of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b02073fb573e7c331880e4cd324ed1d
https://pubmed.ncbi.nlm.nih.gov/10717483
https://pubmed.ncbi.nlm.nih.gov/10717483