Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jessica B. Mills"'
Publikováno v:
Journal of Occupational and Environmental Hygiene. 10:250-258
We evaluated the robust, lightweight DiSCmini (DM) aerosol monitor for its ability to measure the concentration and mean diameter of submicrometer aerosols. Tests were conducted with monodispersed and polydispersed aerosols composed of two particle t
Autor:
Rouchelle J. Mireles, Jessica B. Mills, Sonia M. de Morais, Bo Feng, Matthew D. Troutman, John S. Janiszewski, Ralph E. Davidson
Publikováno v:
Drug Metabolism and Disposition. 36:268-275
Thirty-one structurally diverse marketed central nervous system (CNS)-active drugs, one active metabolite, and seven non-CNS-active compounds were tested in three P-glycoprotein (P-gp) in vitro assays: transwell assays using MDCK, human MDR1-MDCK, an
Autor:
Jennifer L. Liras, Sonia M. de Morais, Jessica B. Mills, Odette A. Fahmi, Sharon L. Ripp, Tristan S. Maurer, Kristen A. Trevena
Publikováno v:
Drug Metabolism and Disposition. 34:1742-1748
Cytochrome P4503A4 (CYP3A4) is the principal drug-metabolizing enzyme in human liver. Drug-drug interactions (DDIs) caused by induction of CYP3A4 can result in decreased exposure to coadministered drugs, with potential loss of efficacy. Immortalized
Autor:
Cuiping Chen, Rouchelle J. Mireles, Jian Lin, Jessica B. Mills, Scott D. Campbell, Jinghai J. Xu, Teresa A. Smolarek
Publikováno v:
Drug Metabolism and Disposition. 33:537-546
The present study examined the interaction of four 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (atorvastatin, lovastatin, and simvastatin in acid and lactone forms, and pravastatin in acid form only) with multidrug resistance gene 1 (M
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:303-309
Induction of drug-metabolizing enzymes and transporters can cause drug-drug interactions and loss of efficacy. In vitro induction studies traditionally use primary hepatocyte cultures and enzyme activity with selected marker compounds. We investigate