Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jessica B Behring"'
Autor:
Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Aly Elezaby, Xiaoyan Yin, Deborah A Siwik, Francesca Seta, Catherine E Costello, Richard A Cohen, Reiko Matsui, Wilson S Colucci, Mark E McComb, Markus M Bachschmid
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144025 (2015)
Reactive protein cysteine thiolates are instrumental in redox regulation. Oxidants, such as hydrogen peroxide (H2O2), react with thiolates to form oxidative post-translational modifications, enabling physiological redox signaling. Cardiac disease and
Externí odkaz:
https://doaj.org/article/17226e23b1354d9a9df939a220b367f6
Autor:
Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz:
https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
Autor:
Yvonne M. W. Janssen-Heininger, Beatriz Ferrán, Brian S. H. Chong, Yoshimitsu Yura, Richard A. Cohen, Yosuke Watanabe, Colin E. Murdoch, Mark E. McComb, Yuko Tsukahara, Markus Bachschmid, Reiko Matsui, Jessica B. Behring, Ryan D. Johnson, Catherine E. Costello
Publikováno v:
FASEB J
Glutaredoxin-1 (Glrx) is a small cytosolic enzyme that removes S-glutathionylation, glutathione adducts of protein cysteine residues, thus modulating redox signaling and gene transcription. Although Glrx up-regulation prevented endothelial cell (EC)
Autor:
Richard A. Cohen, Xiuyun Hou, Di Shao, Markus Bachschmid, Hemant K. Roy, Francesca Seta, Jessica L. Fry, Michelle T. Long, Jingyan Han, Jessica B. Behring, Reiko Matsui
Publikováno v:
Antioxidants & Redox Signaling. 27:313-327
Aims: Nonalcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity, and diabetes that is rising in prevalence worldwide. Various molecular perturbations of key regulators and enzymes in hepatic lipid metabolis
Autor:
Markus Bachschmid, Olga Gorelenkova Miller, Sandra L. Siedlak, John J. Mieyal, Sirui Jiang, Xiongwei Zhu, Jessica B. Behring, Reiko Matsui
Publikováno v:
Antioxidants & Redox Signaling. 25:967-982
Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation
Autor:
Arshag D. Mooradian, Matthew J. Egan, Gregory R. Bowman, Jason M. Held, Maxwell I. Zimmerman, Sjoerd van der Post, Jessica B. Behring, Jenna L. Clements
Publikováno v:
Sci Signal
Stimulation of receptor tyrosine kinases (RTK) such as EGF locally increase reactive oxygen species (ROS) levels at the plasma membrane that oxidize cysteines in proteins to enhance downstream signaling. Spatial confinement of ROS is an important reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3508992b0d5657996204aacb557dc885
https://doi.org/10.1101/624304
https://doi.org/10.1101/624304
Autor:
Christine C. Winterbourn, Marjolein Soethoudt, Markus Bachschmid, Paul E. Pace, Jessica B. Behring, Louise N. Paton, Alexander V. Peskin
Publikováno v:
Journal of Biological Chemistry. 291:3053-3062
Peroxiredoxin 2 (Prx2) is a thiol protein that functions as an antioxidant, regulator of cellular peroxide concentrations, and sensor of redox signals. Its redox cycle is widely accepted to involve oxidation by a peroxide and reduction by thioredoxin
Publikováno v:
Free Radical Biology and Medicine. 128:S62
EGF coordinates ROS production with altered antioxidant activity to signal through cysteines, which selectively respond according to their proximity to ROS and the local redox state. Cysteine-based redox regulation transduces signals by modulating pr
Autor:
Jason M. Held, Jessica B. Behring, Christopher C. Benz, Alexandria K. D’Souza, Dylan J. Sorensen, Birgit Schilling, Tara Srinivasan, Bradford W. Gibson
Publikováno v:
International Journal of Proteomics
The receptor tyrosine kinase ErbB2 is a breast cancer biomarker whose posttranslational modifications (PTMs) are a key indicator of its activation. Quantifying the expression and PTMs of biomarkers such as ErbB2 by selected reaction monitoring (SRM)
Autor:
Colin E. Murdoch, Dagmar J. Haeussler, Yosuke Watanabe, Victoria M. Bolotina, Alicia M. Evangelista, Jingyan Han, Jessica B. Behring, Melissa D. Smith, Yu Mei, Markus Bachschmid, Richard A. Cohen, Xiaoyong Tong, Reiko Matsui
The endothelium produces and responds to reactive oxygen and nitrogen species (RONS), providing important redox regulation to the cardiovascular system in physiology and disease. In no other situation are RONS more critical than in the response to ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbfd64eaeca81191464dd0ad677f60f
https://publications.aston.ac.uk/id/eprint/28087/1/Endothelial_cell_redox_regulation_of_ischemic_angiogenesis.pdf
https://publications.aston.ac.uk/id/eprint/28087/1/Endothelial_cell_redox_regulation_of_ischemic_angiogenesis.pdf