Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jessica Able"'
Autor:
Robert K. McNamara, Jessica Able, Ronald Jandacek, Therese Rider, Patrick Tso, Diana M. Lindquist
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 405-411 (2009)
To investigate the effects of omega-3 fatty acid deficiency on phosphatidylinositol signaling in brain, myo-inositol (mI) concentrations were determined in the prefrontal cortex (PFC) of omega-3 fatty acid deficient rats by in vivo proton magnetic re
Externí odkaz:
https://doaj.org/article/a38337b325074b1f9cba18669fb10905
Autor:
Jessica Able, Benjamin C. Milgram, Loren Berry, Melanie Cooke, Liyue Huang, John Butler, Hongbing Huang, Violeta Yu, Kristin Taborn, John D. Roberts, Steven Altmann, Margaret Y. Chu-Moyer, John Yeoman, Jean Wang, Roman Shimanovich, Russell Graceffa, Matthew Weiss, Thomas Kornecook, Christopher P Ilch, Bryan D. Moyer, Christiane Boezio, Isaac E. Marx, Brian A. Sparling, Emily A. Peterson, Gwen Rescourio, Charles Kreiman, Elma Feric Bojic, Karina R. Vaida, Angel Guzman-Perez, Dawn Zhu, Hua Gao, Laurie B. Schenkel, Michael Jarosh, Hanh Nho Nguyen, Joseph Ligutti, Alessandro Boezio, Hakan Gunaydin, Daniel S. La, Thomas Dineen, Robert T. Fremeau, Robert S. Foti, Min-Hwa Jasmine Lin, Erin F. DiMauro, John Stellwagen
Publikováno v:
Journal of Medicinal Chemistry. 60:5990-6017
Because of its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6062704d531ce83c1a6122ecc44600
https://doi.org/10.1021/acs.jmedchem.6b01850
https://doi.org/10.1021/acs.jmedchem.6b01850
Autor:
Robert S. Foti, Brian A. Sparling, Thomas Kornecook, Erin F. DiMauro, Joseph Ligutti, Angel Guzman-Perez, Shuyan Yi, Howie Bregman, Michael Jarosh, Hua Gao, Hongbing Huang, Violeta Yu, Beth D. Youngblood, Bryan D. Moyer, Jessica Able, Benjamin Charles Milgram, Matthew Weiss
Publikováno v:
MedChemComm. 8:744-754
NaV1.7 is a particularly compelling target for the treatment of pain. Herein, we report the discovery and evaluation of a series of piperazine amides that exhibit state-dependent inhibition of NaV1.7. After demonstrating significant pharmacodynamic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0547c7c59fef471565d7454331d0af
https://doi.org/10.1039/c6md00578k
https://doi.org/10.1039/c6md00578k
Autor:
Russell F, Graceffa, Alessandro A, Boezio, Jessica, Able, Steven, Altmann, Loren M, Berry, Christiane, Boezio, John R, Butler, Margaret, Chu-Moyer, Melanie, Cooke, Erin F, DiMauro, Thomas A, Dineen, Elma, Feric Bojic, Robert S, Foti, Robert T, Fremeau, Angel, Guzman-Perez, Hua, Gao, Hakan, Gunaydin, Hongbing, Huang, Liyue, Huang, Christopher, Ilch, Michael, Jarosh, Thomas, Kornecook, Charles R, Kreiman, Daniel S, La, Joseph, Ligutti, Benjamin C, Milgram, Min-Hwa Jasmine, Lin, Isaac E, Marx, Hanh N, Nguyen, Emily A, Peterson, Gwen, Rescourio, John, Roberts, Laurie, Schenkel, Roman, Shimanovich, Brian A, Sparling, John, Stellwagen, Kristin, Taborn, Karina R, Vaida, Jean, Wang, John, Yeoman, Violeta, Yu, Dawn, Zhu, Bryan D, Moyer, Matthew M, Weiss
Publikováno v:
Journal of medicinal chemistry. 60(14)
Because of its strong genetic validation, Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8ea84d65ab7dd59414c7bfc36426140
https://pubmed.ncbi.nlm.nih.gov/28324649
https://pubmed.ncbi.nlm.nih.gov/28324649
Autor:
Robert T. Fremeau, Robert S. Foti, Hanh Nho Nguyen, Jeff S. McDermott, Jean Wang, Christiane Bode, Bingfan Du, Joseph Ligutti, Thomas Dineen, Hua Gao, Thomas Kornecook, Jonathan Roberts, Brian E. Hall, Charles Kreiman, Liyue Huang, Matthew Weiss, Jessica Able, Min-Hwa Jasmine Lin, Paul E. Rose, Isaac E. Marx, Emily A. Peterson, Violeta Yu, Erin F. DiMauro, Bryan D. Moyer, Daniel S. La, Beth D. Youngblood, Dong Liu, Margaret Y. Chu-Moyer, Hakan Gunaydin, Howard Bregman
Human genetic evidence has identified the voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e82bfc2625ad2b8c686cc56a8b01002
https://europepmc.org/articles/PMC5346988/
https://europepmc.org/articles/PMC5346988/
Autor:
Jianxia Shi, Xiaoning Zhao, Samer Chmait, Mary Dovlatyan, Silke Miller, Kristin L. Andrews, Geraldine Hill Della Puppa, James J. S. Treanor, Dianna Lester-Zeiner, Carl Davis, Essa Hu, Christopher Biorn, Jessica Able, Hang Chen, Jennifer R. Allen, Ji Ma
Publikováno v:
ACS Medicinal Chemistry Letters. 5:700-705
We report the discovery of novel imidazo[4,5-b]pyridines as potent and selective inhibitors of PDE10A. The investigation began with our recently disclosed ketobenzimidazole 1, which exhibited single digit nanomolar PDE10A activity but poor oral bioav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f48b3d8c765bcbadc35e47aee5474f6
https://doi.org/10.1021/ml5000993
https://doi.org/10.1021/ml5000993
Autor:
Min-Hwa Jasmine Lin, Paul E. Rose, Violeta Yu, Hakan Gunaydin, Robert T. Fremeau, Charles Kreiman, Daniel S. La, Joseph Ligutti, Matthew Weiss, Beth D. Youngblood, Thomas Dineen, Thomas Kornecook, Dong Liu, Bingfan Du, Brian E. Hall, Erin F. DiMauro, Jean Wang, Isaac E. Marx, Robert S. Foti, Emily A. Peterson, Jessica Able, Liyue Huang, Margaret Chu-Moyer, Jeff S. McDermott, Christiane Bode, Bryan D. Moyer, Howard Bregman, Jonathan Roberts, Hua Gao
Human genetic evidence has identified the voltage-gated sodium channel NaV1.7 as an attractive target for the treatment of pain. We initially identified naphthalene sulfonamide 3 as a potent and selective inhibitor of NaV1.7. Optimization to reduce b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45d3cf7f30dc5240f9068aa183a1600
https://europepmc.org/articles/PMC5150675/
https://europepmc.org/articles/PMC5150675/
Autor:
Dah-Ren Hwang, Geraldine Hill Della Puppa, Jamie Wong, Essa Hu, Thomas Nixey, Silke Miller, Hang Chen, Jessica Able, Dianna Lester-Zeiner, James J. S. Treanor, Robert Cho, Santosh Talreja, Roxanne Kunz, Jianxia Shi, Ji Ma, David C. Immke, Jennifer R. Allen, Christopher Biorn, Amy Porter, Klaus Michelsen, Shannon Rumfelt, Stephen Hitchcock
Publikováno v:
Journal of Medicinal Chemistry. 55:4776-4787
A radiolabeled tracer for imaging therapeutic targets in the brain is a valuable tool for lead optimization in CNS drug discovery and for dose selection in clinical development. We report the rapid identification of a novel phosphodiesterase 10A (PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626c862c5f50bd2845e3c603ba24a357
https://doi.org/10.1021/jm3002372
https://doi.org/10.1021/jm3002372
Autor:
Hu Ye, Tim Kazules, Ji Ma, Dianna Lester-Zeiner, Essa Hu, Santosh Talreja, Carl Davis, Charlie Glaus, Oliver R. Thiel, Ning Chen, Geraldine Hill Della Puppa, James J. S. Treanor, Shannon Rumfelt, Hui Hannah Dou, Roxanne Kunz, David C. Immke, Jessica Able, Jennifer R. Allen, Silke Miller, Xiaoning Zhao, Hang Chen, Jianxia Shi, Jamie Wong, Toni Williamson, Christopher Biorn, Amy Porter, Klaus Michelsen, Ada Chen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(2)
Phosphodiesterase 10A (PDE10A) inhibitors have therapeutic potential for the treatment of psychiatric and neurologic disorders, such as schizophrenia and Huntington's disease. One of the key requirements for successful central nervous system drug dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2114c0263395e74897b10174822cf2a
https://pubmed.ncbi.nlm.nih.gov/25502803
https://pubmed.ncbi.nlm.nih.gov/25502803
Autor:
Kaustav Biswas, Ning Chen, Ji Ma, Xiaoning Zhao, Randall W. Hungate, Carl Davis, Jessica Able, Madelyn Cueva, James J. S. Treanor, Matthew P. Bourbeau, Samer Chmait, Paul E. Harrington, Dianna Lester-Zeiner, Roxanne Kunz, Jianxia Shi, Hang Chen, Jennifer R. Allen, Amy Porter, Kristin L. Andrews, Essa Hu, Jean Danao, Santosh Talreja, Thomas Kornecook
Publikováno v:
Journal of medicinal chemistry. 57(15)
We report the identification of a PDE10A clinical candidate by optimizing potency and in vivo efficacy of promising keto-benzimidazole leads 1 and 2. Significant increase in biochemical potency was observed when the saturated rings on morpholine 1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad7ef7d24660d5c9e596de78a69b3f2
https://pubmed.ncbi.nlm.nih.gov/25062128
https://pubmed.ncbi.nlm.nih.gov/25062128