Výsledky vyhledávání - "Jessica A.F.D. Silva"

Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Autor: Israel Matos, Maunish Barvalia, Manreet K. Chehal, A. Gordon Robertson, Iva Kulic, Jessica A.F.D. Silva, Abhinandan Ranganathan, Amy Short, Yu-Hsuan Huang, Erin Long, John J. Priatel, Salim Dhanji, Brad H. Nelson, Danielle L. Krebs, Kenneth W. Harder

Publikováno v: Cancer Research Communications. 3:404-419

While immunotherapies such as immune checkpoint blockade and adoptive T-cell therapy improve survival for a subset of human malignancies, many patients fail to respond. Phagocytes including dendritic cells (DC), monocytes, and macrophages (MF) orches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c58b03e0d87c5b4e0ad543399513670
https://doi.org/10.1158/2767-9764.crc-22-0278

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Table TS2 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Autor: Kenneth W. Harder, Danielle L. Krebs, Brad H. Nelson, Salim Dhanji, John J. Priatel, Erin Long, Yu-Hsuan Huang, Amy Short, Abhinandan Ranganathan, Jessica A.F.D. Silva, Iva Kulic, A. Gordon Robertson, Manreet K. Chehal, Maunish Barvalia, Israel Matos

Flow cytometry antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec9a995ecaa9958ac355be08a4e49ab
https://doi.org/10.1158/2767-9764.22546750

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Figure S1 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Supplementary Figure S1 shows the characterization of MT and MTG-CSF-/- cell lines and tumors, including surface protein expression, tumor volume/weight, and immune cell subset content. Composition of immune cells in blood and spleen of MT and MTG-CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4966f5bc3a991561c45cd11aa6dd401f
https://doi.org/10.1158/2767-9764.22546768

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Figure S3 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Supplementary Figure S3 shows deep phenotyping of Neut/MDSCs and B cells in the bone marrow of mice bearing MT or MTG-CSF-/- tumors, using FlowSOM applied in tSNE maps.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c8c0f73ead8b30f58ce885afd185c9
https://doi.org/10.1158/2767-9764.22546759

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Figure S2 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Supplementary Figure S2 compares the immune cell content in peripheral blood and spleens from immunocompetent, immunocompromised and G-CSFR-/- mice harboring MT or MTG-CSF-/- tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad9566fed7c1d54831812bddbdba8aa
https://doi.org/10.1158/2767-9764.22546765.v1

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Table TS1 from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

CyTOF panels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a30dceefceb20ad74c8062fe9380b34
https://doi.org/10.1158/2767-9764.22546753.v1

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Data from Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b701a55c408a41306b8541cf640048d
https://doi.org/10.1158/2767-9764.c.6551242

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Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan

Autor: Israel Matos, Kenneth W. Harder, Jessica A.F.D. Silva, Daven C. Tai, Morgan E. Roberts, Sam Chen, Rachel A. Cederberg, Maunish Barvalia, William Chu, Amanda Wong, Pieter R. Cullis, John J. Priatel

Publikováno v: Circulation Research. 126

Rationale: Monocytes are key effectors of the mononuclear phagocyte system, playing critical roles in regulating tissue homeostasis and coordinating inflammatory reactions, including those involved in chronic inflammatory diseases such as atheroscler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09588ef180aaa7b2f1b68b2880a167d5
https://doi.org/10.1161/circresaha.119.315708

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