Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jessica A. Van Winkle"'
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 33:196-204
A recently discovered protein phosphatase PHLPP (PH domain Leucine-rich repeat Protein Phosphatase) has been shown to dephosphorylate Akt on its hydrophobic motif (Ser473) thereby decreasing Akt kinase activity. We generated PHLPP1 knockout (KO) mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485646441e8031a968dc10f69c5e171f
https://doi.org/10.1038/jcbfm.2012.150
https://doi.org/10.1038/jcbfm.2012.150
Autor:
Patrick D. Lyden, Padmesh S. Rajput, Benedict Pereira, I.-Farn Lei, Bo Chen, Jessica A. Van Winkle
Publikováno v:
Journal of neuroscience methods. 213(1)
Pre-clinical development of therapy for acute ischemic stroke requires robust animal models; the rodent middle cerebral artery occlusion (MCAo) model using a nylon filament inserted into the internal carotid artery is the most popular. Drug screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e752bf4ec45d6ef066087b30eb1517
https://pubmed.ncbi.nlm.nih.gov/23261656
https://pubmed.ncbi.nlm.nih.gov/23261656
Autor:
Michael A. Whitney, Beth Friedman, Lifu Zhao, Roger Y. Tsien, I-Farn Lei, Patrick D. Lyden, Jessica A. Van Winkle, Bo Chen, Qun Cheng, Emilia S. Olson, Benedict Pereira
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(22)
Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular injury during acute focal ischemia. Stroke was induced in adult Sprague Dawl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f474d917517701691afe9114eb754ba9
https://pubmed.ncbi.nlm.nih.gov/22649241
https://pubmed.ncbi.nlm.nih.gov/22649241