Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jessica A. Lasky-Su"'
Autor:
Kevin Mendez, Ines Lains, Rachel S. Kelly, João Gil, Rufino Silva, John Miller, Demetrios G. Vavvas, Ivana Kim, Joan Miller, Liming Liang, Jessica A. Lasky-Su, Deeba Husain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Age-related macular degeneration (AMD) is a leading cause of blindness worldwide, with a complex pathophysiology and phenotypic diversity. Here, we apply Similarity Network Fusion (SNF) to cluster AMD patients into putative metabolomics-deri
Externí odkaz:
https://doaj.org/article/3230ea83c28942a09c1a4962098ea2b8
Autor:
Kevin M. Mendez, Sofina Begum, Anshul Tiwari, Rinku Sharma, Qingwen Chen, Rachel S. Kelly, Nicole Prince, Mengna Huang, Priyadarshini Kachroo, Su H. Chu, Yulu Chen, Kathleen Lee-Sarwar, David I. Broadhurst, Stacey N. Reinke, Robert Gerszten, Clary Clish, Lydiana Avila, Juan C. Celedón, Craig E. Wheelock, Scott T. Weiss, Michael McGeachie, Jessica A. Lasky-Su
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105025- (2024)
Summary: Background: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective stud
Externí odkaz:
https://doaj.org/article/1da55660eee84901b30e4550ba08f293
Autor:
Qi Luo, Varun B. Dwaraka, Qingwen Chen, Huige Tong, Tianyu Zhu, Kirsten Seale, Joseph M. Raffaele, Shijie C. Zheng, Tavis L. Mendez, Yulu Chen, Natalia Carreras, Sofina Begum, Kevin Mendez, Sarah Voisin, Nir Eynon, Jessica A. Lasky-Su, Ryan Smith, Andrew E. Teschendorff
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Changes in cell-type composition of tissues are associated with a wide range of diseases and environmental risk factors and may be causally implicated in disease development and progression. However, these shifts in cell-type frac
Externí odkaz:
https://doaj.org/article/b05b81a3490b4576b2b9a29d275708ee
Autor:
Nicole Prince, Rachel S. Kelly, Su H. Chu, Priyadarshini Kachroo, Yulu Chen, Kevin M. Mendez, Sofina Begum, Hans Bisgaard, Klaus Bønnelykke, Min Kim, Ofer Levy, Augusto A. Litonjua, Craig E. Wheelock, Scott T. Weiss, Bo L. Chawes, Jessica A. Lasky-Su
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Respiratory infections are a leading cause of morbidity and mortality in early life, and recurrent infections increase the risk of developing chronic diseases. The maternal environment during pregnancy can impact offspring health, but the fa
Externí odkaz:
https://doaj.org/article/ad6dafe46ea84769bc12cbb3f2c1820a
Autor:
Martin Ingi Sigurdsson, Hirotada Kobayashi, Karin Amrein, Kiichi Nakahira, Angela J. Rogers, Mayra Pinilla-Vera, Rebecca M. Baron, Laura E. Fredenburgh, Jessica A. Lasky-Su, Kenneth B. Christopher
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-13 (2022)
Abstract Background Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-formylmethionine is a
Externí odkaz:
https://doaj.org/article/4258de9e74664b7f8a175c305bcb5ce2
Autor:
Jaehyun Joo, Angel C. Y. Mak, Shujie Xiao, Patrick M. Sleiman, Donglei Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwakar, Jessica A. Lasky-Su, Scott T. Weiss, Joanne E. Sordillo, Ann C. Wu, Michelle Cloutier, Glorisa Canino, Erick Forno, Juan C. Celedón, Max A. Seibold, Hakon Hakonarson, L. Keoki Williams, Esteban G. Burchard, Blanca E. Himes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator r
Externí odkaz:
https://doaj.org/article/808f2b5b81bf46269caaa117e076f965
Autor:
Zheng Sun, Kathleen Lee-Sarwar, Rachel S. Kelly, Jessica A. Lasky-Su, Augusto A. Litonjua, Scott T. Weiss, Yang-Yu Liu
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104491- (2023)
Summary: Background: It has been widely recognized that a critical time window for neurodevelopment occurs in early life and the host's gut microbiome plays an important role in neurodevelopment. Following recent demonstrations that the maternal pren
Externí odkaz:
https://doaj.org/article/56a57bea4c444433a008a90b40682b25
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Procalcitonin is a biomarker of systemic inflammation and may have importance in the immune response. The metabolic response to elevated procalcitonin in critical illness is not known. The response to inflammation is vitally important to und
Externí odkaz:
https://doaj.org/article/74b49f3ac1674f67bef69711dd30dbad
Autor:
Nicole Prince, Meryl Stav, Margaret Cote, Su H. Chu, Chirag M. Vyas, Olivia I. Okereke, Natalia Palacios, Augusto A Litonjua, Pantel Vokonas, David Sparrow, Avron Spiro, Jessica A. Lasky-Su, Rachel S. Kelly
Publikováno v:
Metabolites, Vol 13, Iss 7, p 851 (2023)
Traditional approaches to understanding metabolomics in mental illness have focused on investigating a single disorder or comparisons between diagnoses, but a growing body of evidence suggests substantial mechanistic overlap in mental disorders that
Externí odkaz:
https://doaj.org/article/f90f860b190840a8a4f44ff4412b4ad6
Autor:
Astrid Sevelsted, Gözde Gürdeniz, Daniela Rago, Casper-Emil Tingskov Pedersen, Jessica A. Lasky-Su, Antonio Checa, Pei Zhang, Craig E. Wheelock, Stine S. Normann, David M. Kristensen, Morten Arendt Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Bo Chawes
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104236- (2022)
Summary: Background: Perfluoroalkyl substances PFOS and PFOA are persistent and bioaccumulative exogenous chemicals in the human body with a range of suspected negative health effects. It is hypothesised that exposure during prenatal and early postna
Externí odkaz:
https://doaj.org/article/daf03bc12b874aedbb2210c9d691f515