Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jessica A. Kretzmann"'
Autor:
Jessica A. Kretzmann, Anna Liedl, Alba Monferrer, Volodymyr Mykhailiuk, Samuel Beerkens, Hendrik Dietz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
DNA origami may enable more versatile gene delivery applications through its ability to create custom nanoscale objects. Here the authors show that genes folded in DNA origami with custom scaffolds express efficiently when delivered to mammalian cell
Externí odkaz:
https://doaj.org/article/a054471706244e8599b5292bb403e4af
Publikováno v:
Journal of the American Chemical Society. 145:4946-4950
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd8cd419769000f7f67d9f9d5590bdb
https://doi.org/10.1021/jacs.2c12733
https://doi.org/10.1021/jacs.2c12733
Autor:
Taewon Jeon, Vincent M. Rotello, Yi-Wei Lee, Cameron W. Evans, Marck Norret, William Jerome, Sanjana Gopalakrishnan, K. Swaminathan Iyer, Jessica A. Kretzmann, David C. Luther
Publikováno v:
Journal of the American Chemical Society. 143:4758-4765
Intracellular protein delivery enables selective regulation of cellular metabolism, signaling, and development through introduction of defined protein quantities into the cell. Most applications require that the delivered protein has access to the cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28ab3c700759929cac38c461a3d7de3
https://doi.org/10.1021/jacs.1c00258
https://doi.org/10.1021/jacs.1c00258
Autor:
Marck Norret, Sky Edwards, Gareth L. Nealon, Cyrille Boyer, K. Swaminathan Iyer, Ruhani Singh, Tristan D. Clemons, Jessica A. Kretzmann, Cameron W. Evans
Publikováno v:
New Journal of Chemistry. 44:20013-20020
Docetaxel (DTX) is a widely used chemotherapy drug that is associated with numerous side effects and limited bioavailability. Macromolecular conjugates of DTX may improve drug targeting, solubility, reduce off-target toxicity, and overcome mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b5fc9d7d9f8847a1c3a126924208a9
https://doi.org/10.1039/d0nj03425h
https://doi.org/10.1039/d0nj03425h
Autor:
Nikolas Gavriel, Chloe G. G. Gray, Marck Norret, Carole A. Bartlett, Sarah A. Dunlop, Priya S. R. Naidu, Melinda Fitzgerald, Nicolas L. Taylor, Charmaine Hee, Jessica A. Kretzmann, K. Swaminathan Iyer, Diwei Ho, Nicole M. Smith, Lillian M. Toomey, Eleanor Denham, Terence McGonigle, Diana Patalwala
Publikováno v:
ACS Applied Materials & Interfaces. 11:22085-22095
The adsorption of serum proteins on the surface of nanoparticles (NPs) delivered into a biological environment has been known to alter NP surface properties and consequently their targeting efficiency. In this paper, we use random copolymer (p(HEMA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5337caedbe7319420717ff137652004e
https://doi.org/10.1021/acsami.9b01356
https://doi.org/10.1021/acsami.9b01356
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:304-311
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized therapeutic gene editing by providing researchers with a new method to study and cure diseases previously considered u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c38a2a78366adab3ea38dac3b40a0b77
https://doi.org/10.1248/bpb.b18-00811
https://doi.org/10.1248/bpb.b18-00811
Autor:
Diwei Ho, K. Swaminathan Iyer, Charmaine Hee, Marck Norret, Gareth L. Nealon, Jessica A. Kretzmann, Amir Karton
Publikováno v:
Chemical Communications. 55:14506-14509
Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for pers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fe193f1d2f76408eca7eddb46d3f8f
https://doi.org/10.1039/c9cc06603a
https://doi.org/10.1039/c9cc06603a
Autor:
K. Swaminathan Iyer, Edina Wang, Marck Norret, Benjamin F. Dessauvagie, Diwei Ho, Colette Moses, Anabel Sorolla, Jessica A. Kretzmann, Pilar Blancafort, Amy L. Kretzmann, Nicole M. Smith, Cameron W. Evans, Andrew Redfern, Charlene Babra Waryah, Mark J. Hackett
Publikováno v:
Chemical Science. 10:7718-7727
Aberrant gene expression is a hallmark of cancer. Although transcription is traditionally considered ‘undruggable’, the development of CRISPR-associated protein 9 (Cas9) systems offers enormous potential to rectify cancer-associated transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::638b0435e54b21e27cf387cae92d0f1f
https://doi.org/10.1039/c9sc01432b
https://doi.org/10.1039/c9sc01432b
Autor:
Massimiliano Massi, Alaa M. Munshi, Jessica A. Kretzmann, Marck Norret, Cameron W. Evans, K. Swaminathan Iyer, Anna Maria Ranieri, RuiLu Feng, Martin Saunders, Diwei Ho
Publikováno v:
RSC Advances. 9:20053-20057
Advances in the field of genome engineering demand the development of efficient non-viral transfection agents capable of delivering multiple distinct nucleic acids efficiently to cells (co-transfection). However, current delivery methods result in lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd9804bb3c3099800fc57a785c0ff9e
https://doi.org/10.1039/c9ra03518d
https://doi.org/10.1039/c9ra03518d
Autor:
Cameron W. Evans, Michael J. Higgins, Nicholas B. Lawler, K. Swaminathan Iyer, Marck Norret, Jessica A. Kretzmann, Lei Feng
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 36(31)
Successful intracellular delivery of therapeutics requires interactions at several liquid-solid interfaces, including cell surface, endosomal membranes, and-depending on the therapeutic-the nuclear membrane. Understanding the dynamics of polymer kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8177f060e30c87af8881ff8f1777f6e6
https://pubmed.ncbi.nlm.nih.gov/32672978
https://pubmed.ncbi.nlm.nih.gov/32672978