Zobrazeno 1 - 10
of 448
pro vyhledávání: '"Jessica A. Hoffman"'
Autor:
Devin P. Effinger, Jessica L. Hoffman, Sarah E. Mott, Sarah N. Magee, Sema G. Quadir, Christian S. Rollison, Daniel Toedt, Maria Echeveste Sanchez, Margaret W. High, Clyde W. Hodge, Melissa A. Herman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Psychedelics have experienced renewed interest following positive clinical effects, however the neurobiological mechanisms underlying effects remain unclear. The paraventricular nucleus of the hypothalamus (PVN) plays an integral role in str
Externí odkaz:
https://doaj.org/article/5c9edec683a641259bc478837e518a8c
Autor:
Junwon Heo, Albino G. Schifino, Jennifer McFaline‐Figueroa, David L. Miller, Jessica R. Hoffman, Emily E. Noble, Sarah M. Greising, Jarrod A. Call
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2835-2850 (2023)
Abstract Background This study was designed to develop an understanding of the pathophysiology of traumatic muscle injury in the context of Western diet (WD; high fat and high sugar) and obesity. The objective was to interrogate the combination of WD
Externí odkaz:
https://doaj.org/article/0c08a7e95cd44e76a2bbcfe91dcbaeb6
Autor:
Jessica R. Hoffman, Hyun-Ji Park, Sruti Bheri, Manu O. Platt, Joshua M. Hare, Sunjay Kaushal, Judith L. Bettencourt, Dejian Lai, Timothy C. Slesnick, William T. Mahle, Michael E. Davis
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107980- (2023)
Summary: Cardiac-derived c-kit+ progenitor cells (CPCs) are under investigation in the CHILD phase I clinical trial (NCT03406884) for the treatment of hypoplastic left heart syndrome (HLHS). The therapeutic efficacy of CPCs can be attributed to the r
Externí odkaz:
https://doaj.org/article/c98aba44087c46edbb4851a882473aa8
Autor:
Muthukumar Gunasekaran, Rachana Mishra, Progyaparamita Saha, David Morales, Wen-Chih Cheng, Arun R. Jayaraman, Jessica R. Hoffman, Lauran Davidson, Ling Chen, Aakash M. Shah, Gregory Bittle, Xuebin Fu, Antariksh Tulshyan, Mohamed Abdullah, Tami Kingsbury, Curt Civin, Peixin Yang, Michael E. Davis, Roberto Bolli, Joshua M. Hare, Sudhish Sharma, Sunjay Kaushal
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104656- (2022)
Summary: Successful cell therapy requires cells to resist the hostile ischemic myocardium, be retained to continue secreting cardioprotective growth factors/exosomes, and resist immunological host responses. Clinically relevant stem/progenitor cells
Externí odkaz:
https://doaj.org/article/cfa3170dcc4846bba20f01a55e64e98d
Autor:
Jessica M. Hoffman, M. Katherine Tolbert, Daniel E. L. Promislow, The Dog Aging Project Consortium, Joshua M Akey, Brooke Benton, Elhanan Borenstein, Marta G Castelhano, Amanda E Coleman, Kate E Creevy, Kyle Crowder, Matthew D Dunbar, Virginia R Fajt, Annette L Fitzpatrick, Unity Jeffery, Erica C Jonlin, Matt Kaeberlein, Elinor K Karlsson, Kathleen F Kerr, Jonathan M Levine, Jing Ma, Robyn L McClelland, Audrey Ruple, Stephen M Schwartz, Sandi Shrager, Noah Snyder-Mackler, Silvan R Urfer, Benjamin S Wilfond
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Osteoarthritis (OA) is one of the most prevalent age-related chronic conditions that afflict companion dogs, and multiple joint supplements are available to prevent or treat OA, though the efficacy of these treatments is controversial. While the demo
Externí odkaz:
https://doaj.org/article/fa849b279a3a4e0784fe4481a3c81bdd
Autor:
Benjamin H. Levine, Jessica M. Hoffman
Publikováno v:
Microorganisms, Vol 11, Iss 6, p 1488 (2023)
The human gut, required for ingesting and processing food, extracting nutrients, and excreting waste, is made up of not just human tissue but also trillions of microbes that are responsible for many health-promoting functions. However, this gut micro
Externí odkaz:
https://doaj.org/article/5ffb1a273779480d9db33f26d5d3d390
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 463-480 (2021)
Background: Wounds with embedded metal fragments are an unfortunate consequence of armed conflicts. In many cases the exact identity of the metal(s) and their long-term health effects, especially on the kidney, are not known. Aim of study: The aim of
Externí odkaz:
https://doaj.org/article/baf4a606351d4154995df66c5fdcd933
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100083- (2022)
Injuries suffered in armed conflicts often result in wounds with embedded metal fragments. Standard surgical guidance has been to leave fragments in place except under certain circumstances; meaning that individuals may carry these retained fragments
Externí odkaz:
https://doaj.org/article/b173e76b364247c1866927594ad88fab
Autor:
David Trac, Jessica R. Hoffman, Sruti Bheri, Joshua T. Maxwell, Manu O. Platt, Michael E. Davis
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1212-1221 (2019)
Abstract Congenital heart disease can lead to severe right ventricular heart failure (RVHF). We have shown that aggregated c‐kit+ progenitor cells (CPCs) can improve RVHF repair, likely due to exosome‐mediated effects. Here, we demonstrate that m
Externí odkaz:
https://doaj.org/article/f5b11caa85804aea85990bcbed1580e9
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 11, p 374 (2022)
Human cardiac-derived c-kit+ stromal cells (CSCs) have demonstrated efficacy in preclinical trials for the treatment of heart failure and myocardial dysfunction. Unfortunately, large variability in patient outcomes and cell populations remains a prob
Externí odkaz:
https://doaj.org/article/aaa2b868372c4fceb2c738b056c67144