Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jessica A. Finn"'
Autor:
Cinque Soto, Jessica A. Finn, Jordan R. Willis, Samuel B. Day, Robert S. Sinkovits, Taylor Jones, Samuel Schmitz, Jens Meiler, Andre Branchizio, James E. Crowe
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Recent advances in DNA sequencing technologies have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in the use of bioinformatics as a means of interrogating an
Externí odkaz:
https://doaj.org/article/edd5c95dc07b4be798f44bcf7e346469
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Antigen recognition by mammalian antibodies represents the most diverse setting for protein-protein interactions, because antibody variable regions contain exceptionally diverse variable gene repertoires of DNA sequences containing combinatorial, non
Externí odkaz:
https://doaj.org/article/b2ca03d67e0142c999a0ca710bab3ed2
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228412 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0100839.].
Externí odkaz:
https://doaj.org/article/375a977ca76f405ab301b461a2e872fd
Autor:
Jessica A Finn, Julia Koehler Leman, Jordan R Willis, Alberto Cisneros, James E Crowe, Jens Meiler
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154811 (2016)
Structural restrictions are present even in the most sequence diverse portions of antibodies, the complementary determining region (CDR) loops. Previous studies identified robust rules that define canonical structures for five of the six CDR loops, h
Externí odkaz:
https://doaj.org/article/95d9151e4e9d4a5c86ca3df27dbc6d1c
Autor:
Pavlo Gilchuk, Iuliia M. Gilchuk, Natalie J. Thornburg, Cinque Soto, Hannah L. Turner, Sheng Li, Robin G. Bombardi, Jinhui Dong, Naveenchandra Suryadevara, James E. Crowe, Elaine C. Chen, Rachel S. Nargi, Jessica A. Finn, Robert H. Carnahan, Sandhya Bangaru, Ryan P. Irving, Jonna B. Westover, Seth J. Zost, Nurgun Kose, Andrew B. Ward, Rachel E. Sutton
Publikováno v:
J Clin Invest
Broadly reactive antibodies targeting the influenza A virus hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against divergent HA subtypes. Here we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac5d3d7701f588a04bd97406e9849eb
https://europepmc.org/articles/PMC8321569/
https://europepmc.org/articles/PMC8321569/
Autor:
James E. Crowe, Alexander M. Sevy, Cinque Soto, Pavlo Gilchuk, Robin G. Bombardi, Nurgun Kose, Robert S. Sinkovits, Jessica A. Finn, Pranathi Matta, Andre Branchizio
Publikováno v:
Nature. 566:398-402
The human genome contains approximately 20 thousand protein-coding genes1, but the size of the collection of antigen receptors of the adaptive immune system that is generated by the recombination of gene segments with non-templated junctional additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96708bbfa27b2d730c62ec80050a98eb
https://doi.org/10.1038/s41586-019-0934-8
https://doi.org/10.1038/s41586-019-0934-8
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100839 (2014)
Recent developments in genetic technologies allow deep analysis of the sequence diversity of immune repertoires, but little work has been reported on the architecture of immune repertoires in mucosal tissues. Antibodies are the key to prevention of i
Externí odkaz:
https://doaj.org/article/4c8021a36a0c4f8e99150fe693d78d35
Autor:
Cinque Soto, Iuliia M. Gilchuk, Jonna B. Westover, Seth J. Zost, Jessica A. Finn, Robin G. Bombardi, Jinhui Dong, Sheng Li, Hannah L. Turner, Pavlo Gilchuk, Rachel S. Nargi, Natalie J. Thornburg, Sandhya Bangaru, Naveenchandra Suryadevara, Andrew B. Ward, Robert H. Carnahan, James E. Crowe, Nurgun Kose, Ryan P. Irving
SUMMARYBroadly reactive antibodies targeting the influenza A hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against divergent HA subtypes. Here we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a86eaa1186ad5a0b902799ce6251ba
https://doi.org/10.1101/2020.12.31.424868
https://doi.org/10.1101/2020.12.31.424868
Autor:
James E. Crowe, Taylor Jones, Jessica A. Finn, Jens Meiler, Robert S. Sinkovits, Cinque Soto, Jordan R. Willis, Samuel Schmitz, Samuel Day, Andre Branchizio
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Background Recent advances in DNA sequencing technologies have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in the use of bioinformatics as a means of interrogating antibody va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af85a8fca832a58bad9c6779c961ed9
http://europepmc.org/articles/PMC7364545
http://europepmc.org/articles/PMC7364545
Autor:
Sheng Li, Hannah L. Turner, Iuliia M. Gilchuk, James E. Crowe, Xueyong Zhu, Andrew B. Ward, Robin G. Bombardi, Michael Schotsaert, Stephen J. Kent, Pavlo Gilchuk, Adolfo García-Sastre, Shanshan Lang, Sandhya Bangaru, Jessica A. Finn, Ian A. Wilson, Nurgun Kose, Hillary A. Vanderven
Publikováno v:
Cell
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0945bbfc86194fe5300ee13eb47a1a
https://europepmc.org/articles/PMC6629437/
https://europepmc.org/articles/PMC6629437/