Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jessica A. Deis"'
Publikováno v:
Molecular Metabolism, Vol 24, Iss , Pp 18-29 (2019)
Objectives: Aging increases the risk for development of adipose tissue dysfunction, insulin resistance, dyslipidemia, and liver steatosis. Lipocalin 2 (Lcn2) deficient mice are more prone to diet-induced obesity and metabolic dysfunction, indicating
Externí odkaz:
https://doaj.org/article/56286481d42e4fb7904eefbcd9f9f58c
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 9, Pp 1644-1658 (2016)
In this study, we investigated the role and mechanism of Niemann-Pick type C (NPC)2 in regulating lysosomal activity, mitophagy, and mitochondrial function in adipocytes. We found that knocking down NPC2 impaired lysosomal activity, as evidenced by t
Externí odkaz:
https://doaj.org/article/b6313f0bd57c48739fc6ba18b42b06a6
Publikováno v:
Molecular Metabolism, Vol 24, Iss, Pp 18-29 (2019)
Molecular Metabolism
Molecular Metabolism
Objectives Aging increases the risk for development of adipose tissue dysfunction, insulin resistance, dyslipidemia, and liver steatosis. Lipocalin 2 (Lcn2) deficient mice are more prone to diet-induced obesity and metabolic dysfunction, indicating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdf350ff0c506d359d6cb950550d5b5
https://doi.org/10.1016/j.molmet.2019.03.007
https://doi.org/10.1016/j.molmet.2019.03.007
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96997 (2014)
Lipocalin 2 (Lcn2) has been recently characterized as a new adipokine having a role in innate immunity and energy metabolism. Nonetheless, the metabolic regulation of Lcn2 production in adipocytes has not been comprehensively studied. To better under
Externí odkaz:
https://doaj.org/article/75e0361013d4433fa0eec496b1369753
Publikováno v:
Journal of Molecular Endocrinology. 61:115-126
Lipocalin-2 (LCN2) has been previously characterized as an adipokine regulating thermogenic activation of brown adipose tissue and retinoic acid (RA)-induced thermogenesis in mice. The objective of this study was to explore the role and mechanism for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526904d61e3af3f0923caa771ccdfffb
https://doi.org/10.1530/jme-18-0017
https://doi.org/10.1530/jme-18-0017
Background/objectives Pentraxin 3 (PTX3) has been characterized as a soluble and multifunctional pattern recognition protein in the regulation of innate immune response. However, little is known about its role in adipose tissue inflammation and obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17764c83159b821712c5dbabfc396892
https://europepmc.org/articles/PMC6997122/
https://europepmc.org/articles/PMC6997122/
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 9, Pp 1644-1658 (2016)
In this study, we investigated the role and mechanism of Niemann-Pick type C (NPC)2 in regulating lysosomal activity, mitophagy, and mitochondrial function in adipocytes. We found that knocking down NPC2 impaired lysosomal activity, as evidenced by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbcdef28ccf49ccbb3a55da7ba7e562
https://doi.org/10.1194/jlr.m066522
https://doi.org/10.1194/jlr.m066522
Autor:
Hong Guo, William S. Blaner, Hongfeng Jiang, Jessica A. Deis, Xiaoli Chen, Rocio Foncea, Sheila M. O'Byrne, David A. Bernlohr, Yuanyuan Zhang
Publikováno v:
Journal of Biological Chemistry. 291:11216-11229
We have recently characterized the role of lipocalin 2 (Lcn2) as a new adipose-derived cytokine in the regulation of adaptive thermogenesis via a non-adrenergic pathway. Herein, we explored a potential non-adrenergic mechanism by which Lcn2 regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e12a05cf2ae60501beaf800e083ab72
https://doi.org/10.1074/jbc.m115.711556
https://doi.org/10.1074/jbc.m115.711556
Autor:
Jessica A. Deis, David A. Bernlohr, Aníbal G. Armién, Douglas G. Mashek, Mara G. Mashek, DonSanjiv Ariyakumar, Xiaoli Chen, Hong Guo, Yuanyuan Zhang, Ming Zhao
Publikováno v:
Journal of Biological Chemistry. 289:22063-22077
In this study, we report that lipocalin 2 (Lcn2), a recently characterized adipokine/cytokine, is a novel regulator of brown adipose tissue (BAT) activation by modulating the adrenergic independent p38 MAPK-PGC-1α-UCP1 pathway. Global Lcn2 knock-out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c6cf86bdb018898adc7523eacbdc23
https://doi.org/10.1074/jbc.m114.559104
https://doi.org/10.1074/jbc.m114.559104
Publikováno v:
The FASEB Journal. 29
Mammalian target of rapamycin (mTOR) is an intracellular sensor of nutrient status and plays a key role in lipid and glucose metabolism. Rapamycin, a specific inhibitor of mTORC1, has been known to...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b19475f01f6c2cf46be761710f4bbdc
https://doi.org/10.1096/fasebj.29.1_supplement.595.17
https://doi.org/10.1096/fasebj.29.1_supplement.595.17