Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jessica A. Castrillon"'
Autor:
Ruth A. Keri, Justin D. Lathia, Raul Rabadan, Elliott M. Antman, Felice C. Lightstone, Jessica A. Castrillon, Rui-Sheng Wang, Tong Hao, Marc Vidal, Zehui Liu, Yadi Zhou, David E. Hill, Hong Yue, Yuan Hou, Joseph Loscalzo, Jiansong Fang, Feixiong Cheng, Junfei Zhao, Yang Wang, William R. Martin, Jing Ma, Charis Eng, Weiqiang Lu, Jin Huang
Publikováno v:
Nat Genet
Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein–protein interaction (PPI) networks within human cells. Here, we show that disease-associated germline var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdb54367490da363c80c4f4d3a0c1d9
https://doi.org/10.1038/s41588-020-00774-y
https://doi.org/10.1038/s41588-020-00774-y
Publikováno v:
Hum Mol Genet
Immune checkpoint blockade (ICB) has become a standard of care in a subset of solid tumors. Although cancer survivorship has extended, rates of durable response of ICB remain poor; furthermore, cardiac adverse effects are emerging, which impact sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e04600a1759a91f5bff1889e74af5cd
https://doi.org/10.1093/hmg/ddaa137
https://doi.org/10.1093/hmg/ddaa137
Autor:
Aditi Kothari, Jos Jonkers, Sven Rottenberg, Jennifer L. Guerriero, Tanvi Visal, Jessica A. Castrillon, Jocelin Pinto, Gerburg M. Wulf, Anita K. Mehta, Constantia Pantelidou, Michelle K. Li, Geoffrey I. Shapiro, Olmo Sonzogni, Dan Wang, Mateus De Oliveria Taveira, Emily M. Cheney, Peter Bouwman
Publikováno v:
Cancer Discovery
Combinatorial clinical trials of PARP inhibitors with immunotherapies are ongoing, yet the immunomodulatory effects of PARP inhibition have been incompletely studied. Here, we sought to dissect the mechanisms underlying PARP inhibitor–induced chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01134756315e2d20348a7260882edd14
https://doi.org/10.1158/2159-8290.cd-18-1218
https://doi.org/10.1158/2159-8290.cd-18-1218
Autor:
Judy Garber, Nadine Tung, Jessica E. Thaxton, Shawn F. Johnson, Sandro Santagata, Madison Oliwa, Peter K. Sorger, Matthew J. Berberich, Emily M. Cheney, Katie E. Hurst, Mikel Lipschitz, Aditi Kothari, José Yélamos, Marian Kalocsay, Mateus de Oliveira Taveira, Anita K. Mehta, Nathan Johnson, Constantia Pantelidou, Deborah A. Dillon, Geoffrey I. Shapiro, Jessica A. Castrillon, Scott J. Rodig, Elizabeth A. Mittendorf, Sarah A. Boswell, Christina A. Hartl, Jia-Ren Lin, William M. Oldham, Jennifer L. Guerriero
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Despite objective responses to PARP inhibition and improvements in progression-free survival compared to standard chemotherapy in patients with BRCA-associated triple-negative breast cancer (TNBC), benefits are transitory. Methods Using hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366006b16db55dab263610298931c15d
https://doi.org/10.1136/jitc-2020-sitc2020.0860
https://doi.org/10.1136/jitc-2020-sitc2020.0860
Autor:
Feixiong Cheng, Tong Hao, Jessica A. Castrillon, Yadi Zhou, Zehui Liu, Joseph Loscalzo, Weiqiang Lu, Justin D. Lathia, Elliott M. Antman, Felice C. Lightstone, Charis Eng, Junfei Zhao, Hong Yue, David E. Hill, Jing Ma, Rui-Sheng Wang, Yang Wang, Raul Rabadan, Jin Huang, William R. Martin, Ruth A. Keri, Yuan Hou, Marc Vidal, Jiansong Fang
Technological and computational advances in genomics and interactomics have made it possible to identify rapidly how disease mutations perturb interaction networks within human cells. In this study, we investigate at large-scale the effects of networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1912b685ad64f649210857236bfffbf8
https://doi.org/10.1101/2020.09.18.302588
https://doi.org/10.1101/2020.09.18.302588
Autor:
Jennifer L. Guerriero, Emily M. Cheney, Anthony Letai, Eric M. Miller, Alaba Sotayo, Anita K. Mehta, Jessica A. Castrillon, Elizabeth A. Mittendorf
Background: The heterogeneity of the breast tumor microenvironment (TME) may contribute to the lack of durable responses to immune checkpoint blockade (ICB), however, mouse models to test this are currently lacking. Proper choice and use of pre-clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b5dc1ec17a100305f2460496033b3b
https://doi.org/10.21203/rs.3.rs-57679/v1
https://doi.org/10.21203/rs.3.rs-57679/v1
Publikováno v:
Hum Mol Genet
An individual’s inherited genetic makeup and acquired genomic variants may account for a significant portion of observable variability in therapy efficacy and toxicity. Pharmacogenomics (PGx) is the concept that treatments can be modified to accoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1c04a27bddbdccc9be667bf346cfe3
https://pubmed.ncbi.nlm.nih.gov/32601683
https://pubmed.ncbi.nlm.nih.gov/32601683
Autor:
Jessica A. Castrillon
Publikováno v:
Cancer Research. 81:1698-1698
Background: Modern therapies in oncology have increased cancer survivorship, as well as the incidence of de novo cardiovascular events. While immune checkpoint inhibitors have shown significant clinical impact in several cancer types, the frequency o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4d1d6da361f1890f8e56f78c094b6e
https://doi.org/10.1158/1538-7445.am2021-1698
https://doi.org/10.1158/1538-7445.am2021-1698
Autor:
Sumaiya Iqbal, Jessica A. Castrillon, Juanjiangmeng Du, Mark J. Daly, Eduardo Pérez-Palma, Patrick May, Dennis Lal, Lisa-Marie Niestroj, Anne H. O’Donnell-Luria, Henrike O. Heyne, Aarno Palotie, Peter Nürnberg
Publikováno v:
Genome Res
Missense variant interpretation is challenging. Essential regions for protein function are conserved among gene family members, and genetic variants within these regions are potentially more likely to confer risk to disease. Here, we generated 2,871
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8049e908ac264cfed5c976344aeeaecb
http://orbilu.uni.lu/handle/10993/39857
http://orbilu.uni.lu/handle/10993/39857
Autor:
Anita K. Mehta, Emily M. Cheney, Jessica A. Castrillon, Jia-Ren Lin, Mateus de Oliveira Taveira, Christina A. Hartl, Nathan T. Johnson, William M. Oldham, Marian Kalocsay, Sarah A. Boswell, Olmo Sonzogni, Constantia Pantelidou, Brett P. Gross, Shawn Johnson, Deborah A. Dillon, Sandro Santagata, Judy E. Garber, Nadine Tung, Elizabeth A. Mittendorf, Gerburg M. Wulf, Geoffrey I. Shapiro, Peter K. Sorger, Jennifer L. Guerriero
Publikováno v:
Cancer Immunology Research. 8:A105-A105
Patients with BRCA-associated triple-negative breast cancer (TNBC) have few effective treatment options. PARP inhibitors are promising, and we recently showed they induce an influx of white blood cells, including CD8+ T cells and macrophages into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e807e39215e6ed7d2c58840f9c8b11af
https://doi.org/10.1158/2326-6074.tumimm19-a105
https://doi.org/10.1158/2326-6074.tumimm19-a105