Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jessica A. Bonzo"'
Autor:
Matthew Boyce, Kristin A. Favela, Jessica A. Bonzo, Alex Chao, Lucina E. Lizarraga, Laura R. Moody, Elizabeth O. Owens, Grace Patlewicz, Imran Shah, Jon R. Sobus, Russell S. Thomas, Antony J. Williams, Alice Yau, John F. Wambaugh
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Understanding the metabolic fate of a xenobiotic substance can help inform its potential health risks and allow for the identification of signature metabolites associated with exposure. The need to characterize metabolites of poorly studied or novel
Externí odkaz:
https://doaj.org/article/7f0aa8ed5d56429591182f917881d06c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8608 (2023)
HNF4α, a member of the nuclear receptor superfamily, regulates the genes involved in lipid and glucose metabolism. The expression of the RARβ gene in the liver of HNF4α knock-out mice was higher versus wildtype controls, whereas oppositely, RARβ
Externí odkaz:
https://doaj.org/article/162e216be20147cc803c0efddf3c48f7
Autor:
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays
Externí odkaz:
https://doaj.org/article/650b871553ac4893ba69a76c57d0eaab
Autor:
Chad N. Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A. Bonzo, Moshe Levi, David J. Waxman, Frank J. Gonzalez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredo
Externí odkaz:
https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa
Autor:
Frank J. Gonzalez, Melinda G. Hollingshead, Kristopher W. Krausz, Raymond D. Divelbiss, Jessica A. Bonzo, Soumen K. Manna, Caroline H. Johnson
Publikováno v:
Metabolites, Vol 3, Iss 3, Pp 658-672 (2013)
Global metabolomics analysis has the potential to uncover novel metabolic pathways that are differentially regulated during carcinogenesis, aiding in biomarker discovery for early diagnosis and remission monitoring. Metabolomics studies with human sa
Externí odkaz:
https://doaj.org/article/7140b7044ca741849a37c2170961b634
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 10; Pages: 8608
HNF4α, a member of the nuclear receptor superfamily, regulates the genes involved in lipid and glucose metabolism. The expression of the RARβ gene in the liver of HNF4α knock-out mice was higher versus wildtype controls, whereas oppositely, RARβ
Publikováno v:
J Environ Sci Health C Toxicol Carcinog
In vitro genotoxicity testing plays an important role in chemical risk assessment. The human B-lymphoblastoid cell line TK6 is widely used as a standard cell line for regulatory safety evaluations. Like many other mammalian cell lines, TK6 cells have
Autor:
Donghwan Kim, Shogo Takahashi, Jessica A. Bonzo, Kritika Karri, Chad Brocker, Moshe Levi, Tisha Melia, Thomas J. Velenosi, Daisuke Aibara, Frank J. Gonzalez, David J. Waxman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Exploring the molecular mechanisms that prevent inflammation during caloric restriction may yield promising therapeutic targets. During fasting, activation of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) promotes the ut
Autor:
Eric D Ciappio, Kristopher W Krausz, Mark Rochman, Takashi Furusawa, Jessica A Bonzo, Lino Tessarollo, Frank J Gonzalez, Michael Bustin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84583 (2014)
High mobility group nucleosome-binding protein 5 (HMGN5) is a chromatin architectural protein that binds specifically to nucleosomes and reduces the compaction of the chromatin fiber. The protein is present in most vertebrate tissues however the phys
Externí odkaz:
https://doaj.org/article/295d227740f246b4babc317a9c3084ff
Autor:
Stephen S. Ferguson, Parth Kothiya, Stephen Siferd, Imran Shah, Jessica A. Bonzo, John F. Wambaugh, John Jack, Rafal P. Witek, Susan D. Hester, Keith A. Houck, Jill A Franzosa, Patrick Hurban, Nancy C. Baker
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays have eval