Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

Autor: Jessica A. Beresford-Webb, Elijah Mak, Monika Grigorova, Samuel J. Daffern, Anthony J. Holland, Shahid H. Zaman

Publikováno v: BJPsych Open, Vol 7 (2021)

Background Diagnosis of prodromal Alzheimer's disease and Alzheimer's disease dementia in people with Down syndrome is a major challenge. The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual

Externí odkaz: https://doaj.org/article/93e23a6d682f451297d45ec6c5e8aa04

Transcutaneous vagus nerve stimulation (t-VNS): A novel effective treatment for temper outbursts in adults with Prader-Willi Syndrome indicated by results from a non-blind study.

Autor: Katherine E Manning, Jessica A Beresford-Webb, Lucie C S Aman, Howard A Ring, Peter C Watson, Stephen W Porges, Chris Oliver, Sally R Jennings, Anthony J Holland

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0223750 (2019)

Temper outbursts are a severe problem for people with Prader-Willi Syndrome (PWS). Previous reports indicate that vagus nerve stimulation (VNS) may reduce maladaptive behaviour in neurodevelopmental disorders, including PWS. We systematically investi

Externí odkaz: https://doaj.org/article/0f95869252534184a1ac1fd07d21ad04

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease

Autor: Bessy Benejam, Sandra V. Loosli, R. Asaad Baksh, Anne Sophie Rebillat, Andrew J. Aschenbrenner, Jason Hassenstab, Johannes Levin, Benjamin L. Handen, Antonia M. W. Coppus, Silvia Sacco, Andre Strydom, Elizabeth Head, Kate E. Thurlow, Sigan L. Hartley, Judith Jaeger, Frederick A. Schmitt, Shahid Zaman, Juan Fortea, Jessica A. Beresford-Webb

Publikováno v: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia, 13
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Alzheimer's & dementia / Diagnosis, assessment & disease monitoring 13(1), e12184 (2021). doi:10.1002/dad2.12184
Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1
Alzheimer's & Dementia, 13, 1

Funder: the LuMind IDSC Foundation
Funder: the Jérôme Lejeune Foundation
Funder: the Verum Foundation
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa4e95345aac705aa76321635ad1ebf
http://europepmc.org/articles/PMC8088591

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline

Autor: Elijah Mak, Jonathan P. Coles, Elizabeth Jones, David K. Menon, Jessica A. Beresford-Webb, Tim D. Fryer, Shahid Zaman, Monika Grigorova, Stephanie Brown, Isabel C. H. Clare, Madeline Walpert, Young T. Hong, Franklin I. Aigbirhio, Peter J. Nestor, Anthony J. Holland, Maura Malpetti

Publikováno v: Brain Communications

Positron emission tomography imaging of glucose hypometabolism and amyloid deposition are two well-established methods to evaluate preclinical changes in Alzheimer’s disease and people with Down syndrome. However, the use of both imaging modalities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4acb8fb10e9f825087c5ff860fcefd7
http://europepmc.org/articles/PMC7849981