Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jessica A. Ash"'
Autor:
Jessica A. Ash, Ramon Velazquez, Christy M. Kelley, Brian E. Powers, Stephen D. Ginsberg, Elliott J. Mufson, Barbara J. Strupp
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 32-42 (2014)
Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration. The present study tested the hypothesis that maternal choline s
Externí odkaz:
https://doaj.org/article/3a0dd454c4534da7941f12e6d3e5078a
Autor:
Ramon Velazquez, Jessica A. Ash, Brian E. Powers, Christy M. Kelley, Myla Strawderman, Zoe I. Luscher, Stephen D. Ginsberg, Elliott J. Mufson, Barbara J. Strupp
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 92-101 (2013)
In addition to intellectual disability, individuals with Down syndrome (DS) exhibit dementia by the third or fourth decade of life, due to the early onset of neuropathological changes typical of Alzheimer's disease (AD). Deficient ontogenetic neuroge
Externí odkaz:
https://doaj.org/article/fca5ecc3052d48ea9952e81b5fc18213
Publikováno v:
Cereb Cortex
The CA3 and CA1 principal cell fields of the hippocampus are vulnerable to aging, and age-related dysfunction in CA3 may be an early seed event closely linked to individual differences in memory decline. However, whether the differential vulnerabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7999ee91ca747a33838c1ccfc55ffb8
https://doi.org/10.1093/cercor/bhaa008
https://doi.org/10.1093/cercor/bhaa008
Autor:
Tim Bauer, Martin J. Shipley, Mark A. Sarzynski, Leigh Alexander, Yolanda Hagar, Michael A Hinterberg, Aroon D. Hingorani, Stephen A. Williams, Mika Kivimäki, Juan P. Casas, Sophie Weiss, Christian Jonasson, Claudia Langenberg, Nicholas J. Wareham, Rachel Ostroff, Peter Ganz, Gargi Datta, Jessica Chadwick, Jessica A. Ash, Robert Kirk DeLisle, Claude Bouchard
Publikováno v:
Nat Med
Nature medicine, vol 25, iss 12
Nature Medicine
Nature medicine, vol 25, iss 12
Nature Medicine
Proteins are effector molecules that mediate the functions of genes1,2 and modulate comorbidities3–10, behaviors and drug treatments11. They represent an enormous potential resource for personalized, systemic and data-driven diagnosis, prevention,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3c9c49c93d371832bfa7eddf14f5d6
https://doi.org/10.1038/s41591-019-0665-2
https://doi.org/10.1038/s41591-019-0665-2
Autor:
Christos Davatzikos, Bennett A. Landman, Melissa H. Kitner-Triolo, Brieana Viscomi, Lori L. Beason-Held, Andrea T. Shafer, Luigi Ferrucci, Joshua O. Goh, Susan M. Resnick, Jessica A. Ash
Publikováno v:
Brain Imaging Behav
The hippocampus and underlying cortices are highly susceptible to pathologic change with increasing age. Using an associative face-scene (Face-Place) encoding task designed to target these regions, we investigated activation and connectivity patterns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948a1c95319b732a3730169ac6b09ad0
https://europepmc.org/articles/PMC9188742/
https://europepmc.org/articles/PMC9188742/
Autor:
Carine Pose, Christopher Randolph, Jeffrey Kaye, Karen Ritchie, Bruce Albala, Jessica A. Ash, Joel H. Kramer, Craig W. Ritchie, Marion Mortamais, John Harrison, Michael T. Ropacki
Publikováno v:
Mortamais, M, Ash, J A, Harrison, J, Kaye, J, Kramer, J, Randolph, C, Pose, C, Albala, B, Ropacki, M, Ritchie, C W & Ritchie, K 2017, ' Detecting cognitive changes in preclinical Alzheimer's disease : A review of its feasibility ', Alzheimer's and Dementia, vol. 13, no. 4, pp. 468-492 . https://doi.org/10.1016/j.jalz.2016.06.2365
Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer's disease (AD). Cognitive dysfunction has been viewed, however, as a late-stage phenomenon, despite increasing evidence that changes may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8317965bbb19f872bf6059a1a08f44f7
https://doi.org/10.1016/j.jalz.2016.06.2365
https://doi.org/10.1016/j.jalz.2016.06.2365
Autor:
Barbara J. Strupp, Christy M. Kelley, Jessica A. Ash, Brian E. Powers, Ramon Velazquez, Melissa J. Alldred, Stephen D. Ginsberg, Elliott J. Mufson, Myla Strawderman
Publikováno v:
Brain Structure and Function. 221:4337-4352
Individuals with Down syndrome (DS) exhibit intellectual disability and develop Alzheimer's disease-like neuropathology during the third decade of life. The Ts65Dn mouse model of DS exhibits key features of both disorders, including impairments in le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c5cf4a7cb91e83449d9240a5f2a1d3
https://doi.org/10.1007/s00429-015-1164-y
https://doi.org/10.1007/s00429-015-1164-y
Autor:
Marie A. Caudill, Brian E. Powers, Barbara J. Strupp, Jessica A. Ash, Melissa J. Alldred, Myla Strawderman, Ramon Velazquez, Stephen D. Ginsberg, Elliott J. Mufson, Christy M. Kelley
Publikováno v:
Current Alzheimer Research. 13:97-106
Although Down syndrome (DS) can be diagnosed prenatally, currently there are no effective treatments to lessen the intellectual disability (ID) which is a hallmark of this disorder. Furthermore, starting as early as the third decade of life, DS indiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9fe412eff7e11c71d489bf874983dd
https://doi.org/10.2174/1567205012666150921100311
https://doi.org/10.2174/1567205012666150921100311
Autor:
Jessica A. Ash, Peter R. Rapp
Publikováno v:
Ageing Research Reviews. 15:44-50
Basic research on neurocognitive aging has traditionally adopted a reductionist approach in the search for the basis of cognitive preservation versus decline. However, increasing evidence suggests that a network level understanding of the brain can p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9492681853c194bdebc231c21cf48b46
https://doi.org/10.1016/j.arr.2014.02.001
https://doi.org/10.1016/j.arr.2014.02.001
Autor:
Elliott J. Mufson, Barbara J. Strupp, Stephen D. Ginsberg, Christy M. Kelley, Brian E. Powers, Jessica A. Ash, Ramon Velazquez
Publikováno v:
Journal of Comparative Neurology. 522:1390-1410
Down syndrome (DS), trisomy 21, is a multifaceted condition marked by intellectual disability and early presentation of Alzheimer's disease (AD) neuropathological lesions including degeneration of the basal forebrain cholinergic neuron (BFCN) system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd36a3b9159571e3e5589a11c99a6516
https://doi.org/10.1002/cne.23492
https://doi.org/10.1002/cne.23492