Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jessica A Lehoczky"'
Autor:
Jessica A Lehoczky, Peedikayil E Thomas, Kevin M Patrie, Kailey M Owens, Lisa M Villarreal, Kenneth Galbraith, Joe Washburn, Craig N Johnson, Bryant Gavino, Alexander D Borowsky, Kathleen J Millen, Paul Wakenight, William Law, Margaret L Van Keuren, Galina Gavrilina, Elizabeth D Hughes, Thomas L Saunders, Lesil Brihn, Joseph H Nadeau, Jeffrey W Innis
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003967 (2013)
Mouse early transposon insertions are responsible for ~10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan m
Externí odkaz:
https://doaj.org/article/7e2168f239154d7b8e91247117543900
Autor:
Vivian Jou, Jessica A. Lehoczky
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Understanding the remarkable capacity of vertebrates to naturally regenerate injured body parts has great importance for potential translation into human therapeutic applications. As compared to other vertebrates, mammals have low regenerative capaci
Externí odkaz:
https://doaj.org/article/033dc9858fc24090979e094ee1678b48
Autor:
Nandini Krishnamoorthy, Katherine H. Walker, Thayse R. Brüggemann, Luciana P. Tavares, Ethan W. Smith, Julie Nijmeh, Yan Bai, Xingbin Ai, R. Elaine Cagnina, Melody G. Duvall, Jessica A. Lehoczky, Bruce D. Levy
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The resolution of infection is an active process with specific molecular and cellular mechanisms that temper inflammation and enhance pathogen clearance. Here, the specialized pro-resolving mediator (SPM) Maresin 1 (MaR1) inhibited respiratory syncyt
Publikováno v:
Cell reports. 41(8)
The mouse digit tip is a complex tissue that is capable of regeneration after amputation. How the regenerated digit tip is patterned is unknown, but a long-standing hypothesis in the field of regeneration proposes that developmental patterning mechan
Autor:
Kaetlin Vasquez, Deepak Kaji, Jessica A. Lehoczky, Wesley Huang, Zhijia Tan, Kathryn S.E. Cheah, Gemma L. Johnson, Alice H. Huang, Benjamin Levi
Publikováno v:
J Orthop Res
In this review, we highlight themes from a recent workshop focused on "Plasticity of Cell Fate in Musculoskeletal Tissues" held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plas
Leucine-rich repeat containing G-protein-coupled receptor 6 (LGR6) is a marker of osteoprogenitor cells and is dynamically expressed during in vitro osteodifferentation of mouse and human mesenchymal stem cells (MSCs). While the Lgr6 genomic locus ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63e897a6a5f21138b23d7761ffc638ca
https://doi.org/10.1101/2021.07.16.452698
https://doi.org/10.1101/2021.07.16.452698
Autor:
Gemma L. Johnson, Jessica A. Lehoczky
Publikováno v:
Cold Spring Harbor Perspectives in Biology. 14:a040857
In this review, we present the current state of knowledge surrounding mammalian digit tip regeneration. We discuss the origin and formation of the blastema, a structure integral to digit tip regeneration, as well as recent insights driven by single-c
Autor:
Jessica A. Lehoczky
Publikováno v:
Experimental Dermatology. 26:478-482
Some mammalian digit tips, including those of mice and human children, can regenerate following amputation, whereas mammalian limb regeneration does not occur. One major difference between the digit tip and the rest of the limb is the presence of the
Innate regeneration following digit tip amputation is one of the few examples of epimorphic regeneration in mammals. Digit tip regeneration is mediated by the blastema, the same structure invoked during limb regeneration in some lower vertebrates. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76fca16cf3758c423c022efa2d0bd08
https://doi.org/10.1101/737023
https://doi.org/10.1101/737023
Autor:
Clifford J. Tabin, Jessica A. Lehoczky
Publikováno v:
Proceedings of the National Academy of Sciences. 112:13249-13254
The tips of the digits of some mammals, including human infants and mice, are capable of complete regeneration after injury. This process is reliant on the presence of the overlaying nail organ and is mediated by a proliferative blastema. Epithelial