Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jessica A Kotov"'
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0270907 (2022)
Multiple myeloma (MM), a malignancy of plasma cells (PCs), has diverse genetic underpinnings and in rare cases these include amplification of the lymphotoxin b receptor (Ltbr) locus. LTβR has well defined roles in supporting lymphoid tissue developm
Externí odkaz:
https://doaj.org/article/17b68081387347c6baf6e3e78f5c116c
Autor:
Frances V. Sjaastad, Stephanie A. Condotta, Jessica A. Kotov, Kathryn A. Pape, Cody Dail, Derek B. Danahy, Tamara A. Kucaba, Lorraine T. Tygrett, Katherine A. Murphy, Javier Cabrera-Perez, Thomas J. Waldschmidt, Vladimir P. Badovinac, Thomas S. Griffith
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Immunosuppression is one hallmark of sepsis, decreasing the host response to the primary septic pathogens and/or secondary nosocomial infections. CD4 T cells and B cells are among the array of immune cells that experience reductions in number and fun
Externí odkaz:
https://doaj.org/article/73ff433ade8f44b69e31d8fdbc0c3732
Autor:
Jonathan L. Linehan, Dmitri I. Kotov, Marc K. Jenkins, Jessica A. Kotov, Micah D. Gearhart, Vivian J. Bardwell
Publikováno v:
The Journal of Experimental Medicine
Th17 cells provide a protective immunity against extracellular bacterial and fungal pathogens. Kotov et al. identify and characterize a mechanism by which BCOR promotes Th17 formation after Streptococcus pyogenes infection by repressing genes that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c692aec08524db02b8ca4abd7a28e4
https://doi.org/10.1084/jem.20182376
https://doi.org/10.1084/jem.20182376
Autor:
Jessica A. Kotov, Marc K. Jenkins
Publikováno v:
The Journal of Immunology. 202:401-405
The T follicular helper (Tfh) cell subset of CD4+ Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e70da407d579cdc50ed7c32af3ec20
https://doi.org/10.4049/jimmunol.1801349
https://doi.org/10.4049/jimmunol.1801349
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(6)
CD4+ Th cells can have cytotoxic activity against cells displaying relevant peptide-MHC class II (p:MHCII) ligands. Cytotoxicity may be a property of Th1 cells and depends on perforin and the Eomes transcription factor. We assessed these assertions f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13952ae1cdaf679e17fbd077d67805ea
https://pubmed.ncbi.nlm.nih.gov/29436413
https://pubmed.ncbi.nlm.nih.gov/29436413
Publikováno v:
The Journal of Immunology. 200:110.7-110.7
CD4+ T helper 17 (Th17) cells protect against pathogens at mucosal barriers by secreting cytokines that drive clearance of the pathogen by neutrophils. We found that Bcl6 interacting corepressor (BCOR) drives Th17 cell formation after Streptococcus p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b21a4f7ea11ee7a040ddedcf0dc7d9
https://doi.org/10.4049/jimmunol.200.supp.110.7
https://doi.org/10.4049/jimmunol.200.supp.110.7
Autor:
Dmitri Ivanovich Kotov, Jason S. Mitchell, Thomas Pengo, Jessica Amy Kotov, Christiane Ruedl, Sing Sing Y. Way, Ryan A. Langlois, Brian T. Fife, Marc K. Jenkins
Publikováno v:
The Journal of Immunology. 200:171.2-171.2
Naïve CD4+ T lymphocytes differentiate into various subsets when their TCRs detect microbial peptide-MHCII complexes presented by dendritic cells. However, the mechanism by which TCR signaling influences differentiation is unknown. We found that low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb594d323b05c075124be9575b87c9ab
https://doi.org/10.4049/jimmunol.200.supp.171.2
https://doi.org/10.4049/jimmunol.200.supp.171.2