Výsledky vyhledávání - "Jessica, Perer"

Akademický článek

Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis

Autor: Cody J. Schmidlin, Montserrat Rojo de la Vega, Jessica Perer, Donna D. Zhang, Georg T. Wondrak

Publikováno v: Redox Biology, Vol 37, Iss , Pp 101714- (2020)

Radiation therapy is a frontline treatment option for cancer patients; however, the effects of radiotherapy on non-tumor tissue (e.g. radiation-induced dermatitis) often worsen patient quality of life. Previous studies have implicated the importance

Externí odkaz: https://doaj.org/article/b47dcdf636ff4de6bfcd7a034c74d50b

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Akademický článek

The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis

Autor: Jessica Perer, Jana Jandova, Jocelyn Fimbres, Erin Q. Jennings, James J. Galligan, Anh Hua, Georg T. Wondrak

Publikováno v: Redox Biology, Vol 36, Iss , Pp 101594- (2020)

Sunless (chemical) tanning is widely regarded as a safe alternative to solar UV-induced skin tanning known to be associated with epidermal genotoxic stress, but the cutaneous biology impacted by chemical tanning remains largely unexplored. Chemical t

Externí odkaz: https://doaj.org/article/9572cd4ab46747b6aaa813d280d01b10

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The Glycolysis‐derived α‐Dicarbonyl Metabolite Methylglyoxal is a UVA‐photosensitizer Causing the Photooxidative Elimination of HaCaT Keratinocytes with Induction of Oxidative and Proteotoxic Stress Response Gene Expression †

Autor: Lohanna de Faria Lopes, Jana Jandova, Rebecca Justiniano, Jessica Perer, Maurício S. Baptista, Georg T. Wondrak

Publikováno v: Photochemistry and Photobiology. 99:826-834

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c68d596219a61ffb0faac63f027d1545
https://doi.org/10.1111/php.13717

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The Glycolysis-derived α-Dicarbonyl Metabolite Methylglyoxal is a UVA-photosensitizer Causing the Photooxidative Elimination of HaCaT Keratinocytes with Induction of Oxidative and Proteotoxic Stress Response Gene Expression

Autor: Lohanna, de Faria Lopes, Jana, Jandova, Rebecca, Justiniano, Jessica, Perer, Maurício S, Baptista, Georg T, Wondrak

Publikováno v: Photochemistry and photobiologyREFERENCES.

Cellular oxidative stress contributes to solar ultraviolet (UV) radiation-induced skin photoaging and photocarcinogenesis. Light-driven electron and energy transfer reactions involving non-DNA chromophores are a major source of reactive oxygen specie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513f9d80d2feb3c31c4c320e7557815f
https://pubmed.ncbi.nlm.nih.gov/36109156

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The Endogenous Tryptophan‐derived Photoproduct 6‐formylindolo[3,2‐b]carbazole (FICZ) is a Nanomolar Photosensitizer that Can be Harnessed for the Photodynamic Elimination of Skin Cancer Cells in Vitro and in Vivo

Autor: Jana Jandova, Mauricio S. Baptista, Sophia L. Park, Georg T. Wondrak, Lohanna F. Lopes, Anh Hua, Jessica Perer, Rebecca Justiniano

Publikováno v: Photochem Photobiol
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

UV-chromophores contained in human skin may act as endogenous sensitizers of photooxidative stress and can be employed therapeutically for the photodynamic elimination of malignant cells. Here we report that 6-formylindolo[3,2-b]carbazole (FICZ), a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6cc6fa1ed6e1fa94a10a2036f8aca0
https://doi.org/10.1111/php.13321

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Abstract 4259: PT199, a next generation anti-CD73 mAb that inhibits both membrane-bound and soluble CD73 activity to completion without 'hook effect'

Autor: Haiqun (John) Jia, Jack Li, Fen Pei, Lorraine Greenwood, Lauren Pejza, Yan Long, Kelan Chen, Jessica Perer, Ming Wang, Hui Zou

Publikováno v: Cancer Research. 82:4259-4259

CD73, also known as ecto-5’-nucleotidase, is implicated in promoting immunosuppressive tumor microenvironment (TME) through production of adenosine. The first generation of anti-CD73 therapeutic antibodies currently in clinical studies have largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a0589dca6757164ab9a7dcfe8f9fc9e
https://doi.org/10.1158/1538-7445.am2022-4259

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Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis

Autor: Jessica Perer, Cody J. Schmidlin, Donna D. Zhang, Georg T. Wondrak, Montserrat Rojo de la Vega

Publikováno v: Redox Biology
Redox Biology, Vol 37, Iss, Pp 101714-(2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a7c3b93554c8038b93ea9d4fef5480
http://europepmc.org/articles/PMC7494798

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Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo

Autor: Anh Hua, Jessica Perer, Georg T. Wondrak, Jana Jandova, Jeremy A. Snell

Publikováno v: Cancers
Volume 12
Issue 6
Cancers, Vol 12, Iss 1369, p 1369 (2020)

Metabolic reprogramming is a molecular hallmark of cancer. Recently, we have reported the overexpression of glyoxalase 1 (encoded by GLO1), a glutathione-dependent enzyme involved in detoxification of the reactive glycolytic byproduct methylglyoxal,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f98a4fc90cd1e4d21aebd7b722ced69

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A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin

Autor: Georg T. Wondrak, Christopher M. Cabello, Anh Hua, Jessica Perer, Rebecca Justiniano, Mohammad Fazel, Andrea Krajisnik

Publikováno v: Photochemistry and Photobiology. 93:1472-1482

Nonmelanoma skin cancer (NMSC) is the most common malignancy in the United States representing a considerable public health burden. Pharmacological suppression of skin photo-carcinogenesis has shown promise in preclinical and clinical studies, but mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f27f95367d9d9f8f50df2f1ed3070e9
https://doi.org/10.1111/php.12794

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