Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Jessica, Liegel"'
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Akademický článek
Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model
Autor: Dina Stroopinsky, Jessica Liegel, Manoj Bhasin, Giulia Cheloni, Beena Thomas, Swati Bhasin, Ruchit Panchal, Haider Ghiasuddin, Maryam Rahimian, Myrna Nahas, Shira Orr, Marzia Capelletti, Daniela Torres, Cansu Tacettin, Matthew Weinstock, Lina Bisharat, Adam Morin, Kathleen M. Mahoney, Benjamin Ebert, Richard Stone, Donald Kufe, Gordon J. Freeman, Jacalyn Rosenblatt, David Avigan
Publikováno v: Haematologica, Vol 106, Iss 5 (2021)
We have developed a personalized vaccine whereby patient derived leukemia cells are fused to autologous dendritic cells, evoking a polyclonal T cell response against shared and neo-antigens. We postulated that the dendritic cell (DC)/AML fusion vacci
Externí odkaz: https://doaj.org/article/2a6291d314f043b989dfb3f94c54168f
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2
Personalized tumor vaccine for pancreatic cancer
Autor: Shira, Orr, Ling, Huang, James, Moser, Dina, Stroopinsky, Omar, Gandarilla, Cori, DeCicco, Jessica, Liegel, Cansu, Tacettin, Adam, Ephraim, Giulia, Cheloni, Daniela, Torres, Donald, Kufe, Jacalyn, Rosenblatt, Manuel, Hidalgo, Senthil K, Muthuswamy, David, Avigan
Publikováno v: Cancer Immunology, Immunotherapy. 72:301-313
Pancreatic cancer is a highly lethal malignancy often presenting with advanced disease and characterized by resistance to standard chemotherapy. Immune-based therapies such checkpoint inhibition have been largely ineffective such that pancreatic canc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e097231d91d57f20b0e0294781d6de6
https://doi.org/10.1007/s00262-022-03237-x
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5
Abstract 4076: 4-1bb selection augments DC/AML fusion vaccine-educated T cells for adoptive cell therapy
Autor: Kathrine S. Rallis, Jessica Liegel, Giulia Cheloni, Dina Stroopinsky, Poorva Bindal, Kenel Dufort, Daniela Torres, Isabella Saldarriaga, Samuel Herzlinger, Abigael Morin, Raphael Kesselman, Jeremy Rosenbaum, Georges Chedid, Sophia Adamia, Donald Kufe, Jacalyn Rosenblatt, David Avigan
Publikováno v: Cancer Research. 83:4076-4076
Introduction: Our group has pioneered a novel vaccine by fusion of patient-derived tumor with autologous dendritic cells (DCs) that presents an array of tumor antigens generating a polyclonal immune response. DC/AML vaccination led to expansion of le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::375758a94cc111a020bc649b0810ced6
https://doi.org/10.1158/1538-7445.am2023-4076
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6
Abstract 2257: Activation and clonotypic expansion of the native T cell repertoire identifies durable response to CD19 CAR T cell therapy
Autor: Dimitra Karagkouni, Giulia Cheloni, Yered Pita-Juarez, Daniela Torres, Eleni Kanata, Zachary Avigan, Jessica Liegel, Dina Stroopinsky, Brodie Miles, Gayatri Tiwari, Jenny Kim, Mike Mattie, Jacalyn Rosenblatt, David Avigan, Ioannis Vlachos
Publikováno v: Cancer Research. 83:2257-2257
Background: Axicabtagene ciloleucel (Axi-cel), a CD19 directed CAR T cell therapy, results in durable response in a subset of patients with relapsed/refractory large B cell lymphoma (LBCL) in the absence of persistent circulating CAR T cells. Aim: We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ca864d5a79afe9f8ee3668caa75b7c6
https://doi.org/10.1158/1538-7445.am2023-2257
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