Nonlinear Z‐score modeling for improved detection of cognitive abnormality

Autor: John Kornak, Julie Fields, Walter Kremers, Sara Farmer, Hilary W. Heuer, Leah Forsberg, Danielle Brushaber, Amy Rindels, Hiroko Dodge, Sandra Weintraub, Lilah Besser, Brian Appleby, Yvette Bordelon, Jessica Bove, Patrick Brannelly, Christina Caso, Giovanni Coppola, Reilly Dever, Christina Dheel, Bradford Dickerson, Susan Dickinson, Sophia Dominguez, Kimiko Domoto‐Reilly, Kelley Faber, Jessica Ferrall, Ann Fishman, Jamie Fong, Tatiana Foroud, Ralitza Gavrilova, Deb Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff‐Radford, Neill Graff‐Radford, Ian M. Grant, Murray Grossman, Dana Haley, John Hsiao, Robin Hsiung, Edward D. Huey, David Irwin, David Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, Daniel Kaufer, Diana Kerwin, David Knopman, Ruth Kraft, Joel Kramer, Walter Kukull, Maria Lapid, Irene Litvan, Peter Ljubenkov, Diane Lucente, Codrin Lungu, Ian Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott McGinnis, Emily McKinley, Mario Mendez, Bruce Miller, Namita Multani, Chiadi Onyike, Jaya Padmanabhan, Alexander Pantelyat, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Erik D. Roberson, Emily Rogalski‐Miller, Pheth Sengdy, Les Shaw, Adam M. Staffaroni, Margaret Sutherland, Jeremy Syrjanen, Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, John Trojanowski, Ping Wang, Bonnie Wong, Zbigniew Wszolek, Brad Boeve, Adam Boxer, Howard Rosen, ARTFL/LEFFTDS Consortium

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 797-808 (2019)

Abstract Introduction Conventional Z‐scores are generated by subtracting the mean and dividing by the standard deviation. More recent methods linearly correct for age, sex, and education, so that these “adjusted” Z‐scores better represent whe

Externí odkaz: https://doaj.org/article/a6622d356e19452690bcb069ec439d27

Longitudinal naming and repetition relates to AD pathology and burden in autopsy‐confirmed primary progressive aphasia

Autor: Katheryn A.Q. Cousins, Jessica Bove, Lucia A. A. Giannini, Nikolas G. Kinney, Yvonne R. Balgenorth, Katya Rascovsky, Edward B. Lee, John Q. Trojanowski, Murray Grossman, David J. Irwin

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021)

Abstract Introduction In primary progressive aphasia (PPA) patients with autopsy‐confirmed Alzheimer's disease (AD) or frontotemporal lobar degeneration (FLTD), we tested how the core clinical features of logopenic PPA—naming and repetition—cha

Externí odkaz: https://doaj.org/article/550c100cc4ba44c48677b82215a6fe56

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

Autor: Diane Lucente, Sophia Dominguez, Arthur W. Toga, Ann Fishman, Yvette Bordelon, David J. Irwin, Danielle Brushaber, Debra Gearhart, Katya Rascovsky, Mario F. Mendez, Bradford C. Dickerson, John Kornak, Len Petrucelli, Leah K. Forsberg, Kejal Kantarci, Ping Wang, Zbigniew Wszolek, Anna Karydas, Murray Grossman, Fanny M. Elahi, Ian R. Mackenzie, Patrick Brannelly, Walter A. Kukull, Eliana Marisa Ramos, Edward D. Huey, Kelly Faber, John Q. Trojanowski, Kimiko Domoto-Reilly, Behnaz Ghazanfari, Jill Goldman, David S. Knopman, Emily C. McKinley, Nupur Ghoshal, Ging-Yuek Robin Hsiung, Rosa Rademakers, Masood Manoochehri, Hilary W. Heuer, Walter K. Kremers, Erik D. Roberson, Peter A. Ljubenkov, Adam L. Boxer, David T.W. Jones, Tatiana Foroud, Ian Grant, Brad F. Boeve, Bruce L. Miller, Jonathan Graff-Radford, Miranda Maldonado, Nadine Tatton, Ruth Kraft, Adam M. Staffaroni, Neill Graff-Radford, Joel H. Kramer, Joanne Taylor, Reilly Dever, Irene Litvan, Lynn Bajorek, Giovanni Coppola, Jeremy Syrjanen, Kaitlin B. Casaletto, Yann Cobigo, Codrin Lungu, Namita Multani, Howard J. Rosen, Lynne Jones, Katherine P. Rankin, Julie A. Fields, Alexander Pantelyat, Jaya Padmanabhan, Amy Wolf, Leslie M. Shaw, Brian S. Appleby, Chiadi U. Onyike, Jessica Ferrall, Daniel I. Kaufer, Dana Haley, Diana R. Kerwin, Jessica Bove, M. Carmela Tartaglia, Ralitza H. Gavrilova, Christina Dheel, Christina Caso, Emily Rogalski, Sheng-Yang M. Goh, Madeline Potter, Jamie Fong, Susan Dickinson, Pheth Sengdy, Sandra Weintraub, Bonnie Wong, Scott M. McGinnis, Rodney Pearlman

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association
Alzheimer's & dementia
BASE-Bielefeld Academic Search Engine

Introduction Identifying clinical measures that track disease in the earliest stages of frontotemporal lobar degeneration (FTLD) is important for clinical trials. Familial FTLD provides a unique paradigm to study early FTLD. Executive dysfunction is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec7a979b8097cec86a89c22363f9f0e
http://europepmc.org/articles/PMC6842665

A-185 Influence of Improved Lifetime TBI History Ascertainment on Clinical Outcomes

Autor: Adriana Sandino, Jordan Milano, Breton M Asken, Russell M Bauer, Jessica Bove

Publikováno v: Archives of Clinical Neuropsychology. 37:1340-1340

Objective: History of TBI/concussion earlier in life may have implications for long-term health. It is important to understand factors that influence retrospective reports of TBI/concussion history in the clinic. We examined whether providing a forma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad49c122c5a16e69c10d0eddeae6ee7b
https://doi.org/10.1093/arclin/acac060.185

Social and leisure activity are associated with attenuated cortical loss in behavioral variant frontotemporal degeneration

Autor: Daniel G. Wakeman, Corey T. McMillan, Katheryn A.Q. Cousins, Lauren Massimo, Christopher Olm, Nikolas G. Kinney, Jeffrey S. Phillips, Jessica Bove

Publikováno v: NeuroImage : Clinical
NeuroImage: Clinical, Vol 30, Iss, Pp 102629-(2021)

Highlights • Social and leisure activity may contribute to mitigation of cortical loss in bvFTD. • This relationship was found in regions important for social cognition. • Findings provide new evidence in burgeoning non-AD cognitive reserve lit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97fb40725055e8720f81190df5be507
http://europepmc.org/articles/PMC8024767