Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Autor: Wagstaff LJ, Gomez-Sanchez JA, Fazal SV, Otto GW, Kilpatrick AM, Michael K, Wong LYN, Ma KH, Turmaine M, Svaren J, Gordon T, Arthur-Farraj P, Velasco-Aviles S, Cabedo H, Benito C, Mirsky R, Jessen KR

Publikováno v: eLife
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
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After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::ae4f36c04ecf794ee231effb0ce493e2
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6459

Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion.

Autor: Deborde S; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York., Gusain L; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Powers A; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Marcadis A; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Yu Y; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Chen CH; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Frants A; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Kao E; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Tang LH; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Vakiani E; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Amisaki M; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Balachandran VP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York., Calo A; Institute for Bioengineering of Catalonia, Barcelona, Spain., Omelchenko T; Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York., Jessen KR; Cell and Developmental Biology, University College London, London, United Kingdom., Reva B; Department of Genetics and Genomics Sciences, Mount Sinai Medical Center, New York, New York., Wong RJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Oct 05; Vol. 12 (10), pp. 2454-2473.

Schwann Cells Reprogram Into Repair Phenotype Instead of Dedifferentiating to Immature Phenotype in in Vitro Culture.

Autor: Abd Razak, Nurul Husna¹, Idris, Jalilah¹, Hassan, Nur Hidayah¹, Zaini, Fazlin², Muhamad, Noorzaid², Daud, Muhammad Fauzi¹ mfauzid@unikl.edu.my

Publikováno v: Malaysian Journal of Medicine & Health Sciences. 2023 Supplement, Vol. 19, p107-112. 6p.

STAT3 controls the long-term survival and phenotype of repair Schwann cells during nerve regeneration

Autor: Benito, C, Davis, Cm, Gomez-Sanchez, Ja, Turmaine, M, Meijer, D, Poli, V, Mirsky, R, Jessen, Kr.

Publikováno v: Benito, C, Davies, C M, Gomez-Sanchez, J A, Turmaine, M, Meijer, D, Poli, V, Mirsky, R & Jessen, K R 2017, ' STAT3 controls the long-term survival and phenotype of repair Schwann cells during nerve regeneration ', The Journal of Neuroscience . https://doi.org/10.1523/JNEUROSCI.3481-16.2017
The Journal of Neuroscience

After nerve injury, Schwann cells convert to a phenotype specialized to promote repair. But during the slow process of axonal regrowth, these repair Schwann cells gradually lose their regeneration-supportive features and eventually die. Although this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c7395f533b1362534ef069413295a17
https://hdl.handle.net/20.500.11820/d4d15713-3690-41e0-a615-c134feb0f095

The molecular profile of nerve repair: humans mirror rodents.

Autor: Wilcox MB; Peripheral Nerve Injury Research Unit, Royal National Orthopaedic Hospital, Stanmore; Department of Pharmacology, UCL School of Pharmacy, University College London, London WC1N 1AX; UCL Centre for Nerve Engineering, University College London, London, UK., Jessen KR; UCL Centre for Nerve Engineering; Department of Cell and Developmental Biology, University College London, London, UK., Quick TJ; Peripheral Nerve Injury Research Unit, Royal National Orthopaedic Hospital, Stanmore; UCL Centre for Nerve Engineering, University College London, London, UK., Phillips JB; Department of Pharmacology, UCL School of Pharmacy, University College London, London WC1N 1AX; UCL Centre for Nerve Engineering, University College London, London, UK.

Publikováno v: Neural regeneration research [Neural Regen Res] 2021 Jul; Vol. 16 (7), pp. 1440-1441.