Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jesse Swanson"'
Autor:
Jinqi Liu, Joshua Curtin, Dan You, Stephen Hillerman, Bifang Li-Wang, Rukiye Eraslan, Jenny Xie, Jesse Swanson, Ching-Ping Ho, Simone Oppenheimer, Bethanne M Warrack, Colleen A McNaney, David M Nelson, Jordan Blum, Taeg Kim, Mark Fereshteh, Michael Reily, Petia Shipkova, Anwar Murtaza, Miguel Sanjuan, John T Hunt, Luisa Salter-Cid
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
Immunotherapy has fundamentally changed the landscape of cancer treatment. Despite the encouraging results with the checkpoint modulators, response rates vary widely across tumor types, with a majority of patients exhibiting either primary resistance
Externí odkaz:
https://doaj.org/article/7604dc75ad594b68a709196c2f123df0
Autor:
Shiuhang Yip, Emily Luk, Anwar Murtaza, Yong Zhang, Michael A. Poss, Louis J. Lombardo, Nimmi Raghavan, Zheng Yang, James Kempson, Audris Huang, David R. Tortolani, Jesse Swanson, Xiaoping Hou, Joseph Pawluczyk, James Smalley, Honghe Wan, Karen E. Parrish, Robert M. Borzilleri, Ashok V. Purandare, Karen Augustine-Rauch, Andrew F. Donnell
Publikováno v:
Journal of Medicinal Chemistry. 64:15787-15798
Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models. However, on-target adverse cardiovascular effects have limited the clinical use of TGFβ rec
Autor:
Emily Luk, Karen E. Parrish, Yue-Zhong Shu, Anwar Murtaza, Yongnian Sun, Jinwen Huang, Robert M. Borzilleri, Paul Stetsko, Mary Ellen Cvijic, Jonathan G. Pabalan, Lihong Cheng, Zheng Yang, Jesse Swanson, James R. Burke, Tatyana Zvyaga, James Smalley, Karen A. Augustine
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:137-149
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has a wide array of biological effects. For decades, tumor biology implicated TGF-β as an attractive therapeutic target due to its immunosuppressive effects. Toward this end, mu
Autor:
Jennifer Brown, Karen E. Parrish, Andrew J. Tebben, Jonathan Lippy, Kamalavenkatesh Palanisamy, Todd Kinsella, Chetan Padmakar Darne, Vinay K. Holenarsipur, Anwar Murtaza, Muthalagu Vetrichelvan, Chunhong Yan, Karen Augustine-Rauch, Max Ruzanov, Mark Fereshteh, Upender Velaparthi, Gopal Dhar, Gregory D. Vite, Peiying Liu, Steven Sheriff, Jayakumar Sankara Warrier, Aravind Anandam, Marina Gelman, Arvind Mathur, Barri Wautlet, Robert M. Borzilleri, Hasibur Rahaman, Zheng Yang, Anuradha Gupta, Arun Kumar Gupta, Rajinder Singh, Joseph Fargnoli, Jesse Swanson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Novel imidazole-based TGFβR1 inhibitors were identified and optimized for potency, selectivity, and pharmacokinetic and physicochemical characteristics. Herein, we report the discovery, optimization, and evaluation of a potent, sel
Autor:
Ashvinikumar V. Gavai, Brian E. Fink, Dianlin Xie, Susan Wee, David A Critton, Jesse Swanson, Carolyn Cao, John S. Tokarski, Vijay T. Ahuja, Daniel O'malley, Nicolas Szapiel, Benjamin M. Johnson, Cindy Wang, Anthony A. Paiva
Publikováno v:
ACS Medicinal Chemistry Letters. 10:1486-1491
C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agent...
Autor:
Steven P. Seitz, Gregory D. Vite, John T. Hunt, Mark Fereshteh, Cherney Emily Charlotte, Joseph Fargnoli, Lorell Discenza, Liping Zhang, Jennifer Brown, Xin Li, Kevin Stefanski, Christine Huang, Asoka Ranasinghe, Lisa M. Kopcho, Xiao Zhu, Aaron Balog, Diane Delpy, Sarah C. Traeger, Jesse Swanson, Mary F. Grubb, Zheng Yang, Theresa Ziemba, Kathy A. Johnston, Kimberly A. Foster, Johnni Gullo-Brown, Celia D’Arienzo, Susheel Jethanand Nara, Robert M. Borzilleri, Derrick Maley, Tai-An Lin
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing dioxygenase enzyme implicated in cancer immune response. This account details the discovery of BMS-986242, a novel IDO1 inhibitor designed for the treatment of a variety of c
Autor:
Daniel P, O'Malley, Vijay, Ahuja, Brian, Fink, Carolyn, Cao, Cindy, Wang, Jesse, Swanson, Susan, Wee, Ashvinikumar V, Gavai, John, Tokarski, David, Critton, Anthony A, Paiva, Benjamin M, Johnson, Nicolas, Szapiel, Dianlin, Xie
Publikováno v:
ACS Med Chem Lett
[Image: see text] C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening of an internal kinase
Autor:
Joshua C. Curtin, Stephen Hillerman, Rukiye Eraslan, Jinqi Liu, Dan You, Bifang Li-Wang, Taeg Kim, Anwar Murtaza, John T. Hunt, David M. Nelson, Jesse Swanson, Jordan Blum, Mark Fereshteh, Michael D. Reily, Petia Shipkova, Jenny Xie, Bethanne M. Warrack, Luisa Salter-Cid, Colleen A. McNaney, Simone Oppenheimer, Miguel Sanjuan, Ching-Ping Ho
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
PLoS ONE
PLoS ONE
Immunotherapy has fundamentally changed the landscape of cancer treatment. Despite the encouraging results with the checkpoint modulators, response rates vary widely across tumor types, with a majority of patients exhibiting either primary resistance
Autor:
J. Kwo, V. M. Pereira, Katharina Höfer, Steffen Wirth, Jesse Swanson, S. G. Altendorf, Liu Hao Tjeng, A. Diana Rata, Minghwei Hong, Alexander C. Komarek, Cariad-A. Knight, Christoph Becker, C. N. Wu, Sahana Rößler, Mengxin Guo, Arnold Choa
Publikováno v:
physica status solidi (b). 258:2000346
Autor:
Yufen Zhao, Barri Wautlet, Jonathan Lippy, Anne Rose, Andrew J. Tebben, Gregory D. Vite, Max Ruzanov, Joseph Fargnoli, Liping Zhang, Yong Zhang, Zheng Yang, Karen E. Parrish, Robert M. Borzilleri, Yi Fan, Jesse Swanson, Ching-Ping Ho, Karen Augustine-Rauch, Andrew F. Donnell, Brian E. Fink, Steven Sheriff, Mark Fereshteh
[Image: see text] The multifunctional cytokine TGFβ plays a central role in regulating antitumor immunity. It has been postulated that inhibition of TGFβ signaling in concert with checkpoint blockade will provide improved and durable immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca61cd13f527f4d17df3df6c932c4f3
https://europepmc.org/articles/PMC6231184/
https://europepmc.org/articles/PMC6231184/