Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jesse R. Dixon"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chr
Externí odkaz:
https://doaj.org/article/cbae918c0dab4d61b4ca7ac0bf4ad59f
Autor:
Konstantin Okonechnikov, Aylin Camgöz, Owen Chapman, Sameena Wani, Donglim Esther Park, Jens-Martin Hübner, Abhijit Chakraborty, Meghana Pagadala, Rosalind Bump, Sahaana Chandran, Katerina Kraft, Rocio Acuna-Hidalgo, Derek Reid, Kristin Sikkink, Monika Mauermann, Edwin F. Juarez, Anne Jenseit, James T. Robinson, Kristian W. Pajtler, Till Milde, Natalie Jäger, Petra Fiesel, Ling Morgan, Sunita Sridhar, Nicole G. Coufal, Michael Levy, Denise Malicki, Charlotte Hobbs, Stephen Kingsmore, Shareef Nahas, Matija Snuderl, John Crawford, Robert J. Wechsler-Reya, Tom Belle Davidson, Jennifer Cotter, George Michaiel, Gudrun Fleischhack, Stefan Mundlos, Anthony Schmitt, Hannah Carter, Kulandaimanuvel Antony Michealraj, Sachin A. Kumar, Michael D. Taylor, Jeremy Rich, Frank Buchholz, Jill P. Mesirov, Stefan M. Pfister, Ferhat Ay, Jesse R. Dixon, Marcel Kool, Lukas Chavez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the posterior fossa ependymoma group A. In both groups, tumors occur mainl
Externí odkaz:
https://doaj.org/article/7c75228f7b794031a963791639822393
Autor:
Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Tim Stuart, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Rivkin, Xinxin Wang, Jacinta Lucero, Joseph R. Nery, David A. Davis, Deborah C. Mash, Rahul Satija, Jesse R. Dixon, Sten Linnarsson, Ed Lein, M. Margarita Behrens, Bing Ren, Eran A. Mukamel, Joseph R. Ecker
Publikováno v:
Cell Genomics, Vol 2, Iss 3, Pp 100107- (2022)
Summary: Single-cell technologies measure unique cellular signatures but are typically limited to a single modality. Computational approaches allow the fusion of diverse single-cell data types, but their efficacy is difficult to validate in the absen
Externí odkaz:
https://doaj.org/article/9d2535e5b62c4c61a1c6eee62abb1103
Autor:
Jovylyn Gatchalian, Shivani Malik, Josephine Ho, Dong-Sung Lee, Timothy W. R. Kelso, Maxim N. Shokhirev, Jesse R. Dixon, Diana C. Hargreaves
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The BAF complex is a multi-subunit chromatin remodeling complex that plays important roles in transcription regulation. Here the authors provide evidence that BRD9 and GLTSCR1/BICRA or its paralog GLTSCR1-like/BICRAL define a non-canonical BAF comple
Externí odkaz:
https://doaj.org/article/68252e2a987241adafd12cb3fa6d9025
Autor:
Hanqing Liu, Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph R. Nery, Huaming Chen, Rosa G. Castanon, Songpeng Zu, Yang Eric Li, Jacinta Lucero, Julia K. Osteen, Antonio Pinto-Duarte, Jasper Lee, Jon Rink, Silvia Cho, Nora Emerson, Michael Nunn, Carolyn O’Connor, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng, Chongyuan Luo, Jesse R. Dixon, Bing Ren, M. Margarita Behrens, Joseph R Ecker
Publikováno v:
bioRxiv
Cytosine DNA methylation is essential in brain development and has been implicated in various neurological disorders. A comprehensive understanding of DNA methylation diversity across the entire brain in the context of the brain’s 3D spatial organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc456672ce91c913abcd0b3c00701b9f
https://europepmc.org/articles/PMC10153407/
https://europepmc.org/articles/PMC10153407/
Autor:
Jeesoo Chae, Jin Seok Lee, Jongkeun Park, Dong-Sung Lee, Weon Seo Park, Benjamin Clock, Jesse R. Dixon, Yuh-Seog Jung, Dongwan Hong
Despite the large efforts in international cancer genome consortium studies, there are still a large proportion of tumors with complex genomic rearrangement often remained without a clinically relevant molecular characterization. Integration of multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8c557d6865453b2b3b5b44d66ca4e6c
https://doi.org/10.1101/2022.08.19.504509
https://doi.org/10.1101/2022.08.19.504509
Autor:
Dmitry A. Gordenin, Jesse R. Dixon, Sarah Killcoyne, Erica Lynn, Peter J. Campbell, Manjunath Nimmakayalu, Rebecca C. Fitzgerald, Yanyan Tian, Sahil Seth, Yonathan Lissanu Deribe, John P. O'Brien, Akira Inoue, Victoria T. Le, Roel G.W. Verhaak, Kadir C. Akdemir, Leszek J. Klimczak, Moritz Gerstung, Rafael E. Herrera, Ya-Ping Lin, Lei Li, Justin M. Kim, Samirkumar B. Amin, P. Andrew Futreal, Frederick S. Robinson, Kin Chan, Ashby J. Morrison, Devin A. King
Publikováno v:
Nat Genet
Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the underlying factors that generate somatic mutations is therefore crucial for developing novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1818b109cb8ef8b8d489419624301e0d
https://doi.org/10.1038/s41588-020-0708-0
https://doi.org/10.1038/s41588-020-0708-0
Autor:
Hyeseon Kang, Martin W. Hetzer, Jesse R. Dixon, Maxim N. Shokhirev, Zhichao Xu, Sahaana Chandran
Publikováno v:
Genes Dev
During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated during nuclear reformation in anaphase/telophase. Many aspects of the underlying principles that mediate transcriptional memory and reactivation in the dau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f25ff75b632fc1387d3071b47591384
https://doi.org/10.1101/gad.335794.119
https://doi.org/10.1101/gad.335794.119
Autor:
Tessa M. Popay, Jesse R. Dixon
Publikováno v:
The Journal of biological chemistry. 298(8)
In mammalian organisms, enhancers can regulate transcription from great genomic distances. How enhancers affect distal gene expression has been a major question in the field of gene regulation. One model to explain how enhancers communicate with thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6b3932caf95d3f912835435d7912fd
https://pubmed.ncbi.nlm.nih.gov/35691341
https://pubmed.ncbi.nlm.nih.gov/35691341
Autor:
Robert J. Wechsler-Reya, Siavash R. Dehkordi, James T. Robinson, Meghana Pagadala, Miriam Adam, Jesse R. Dixon, Vineet Bafna, Joshua T. Lange, Edwin F. Juarez, Shanqing Wang, Hannah Carter, Ivy Tsz-Lo Wong, Michael J. Levy, Sunita Sridhar, Sameena Wani, Ashutosh Tiwari, Sahaana Chandran, Owen Chapman, Richard H. Scheuermann, John Robertson Crawford, Jens Luebeck, Ernest Fraenkel, Paul S. Mischel, Scott L. Pomeroy, Lukas Chavez, Jon D. Larson, Denise M. Malicki, Nicole G. Coufal, Yingxi Lin, Jeremy N. Rich, Jill P. Mesirov
SUMMARYExtrachromosomal circular DNA (ecDNA) is an important driver of aggressive tumor growth, promoting high oncogene copy number, intratumoral heterogeneity, accelerated evolution of drug resistance, enhancer rewiring, and poor outcome. ecDNA has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2151d0b16a9efd4796910338cc6de331
https://doi.org/10.1101/2021.10.18.464907
https://doi.org/10.1101/2021.10.18.464907