Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jesse Mager"'
Autor:
Alexandria C. Wells, Kaito A. Hioki, Constance C. Angelou, Adam C. Lynch, Xueting Liang, Daniel J. Ryan, Iris Thesmar, Saule Zhanybekova, Saulius Zuklys, Jacob Ullom, Agnes Cheong, Jesse Mager, Georg A. Hollander, Elena L. Pobezinskaya, Leonid A. Pobezinsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of the CD8 T cell-mediated immune response against infections and tumors depends on the formation of a long-lived memory pool, and the protection of effector cells from exhaustion. The advent of checkpoint blockade therapy has si
Externí odkaz:
https://doaj.org/article/91894239e4cb479a9f76d823674243ce
Autor:
Pilar Cacheiro, Carl Henrik Westerberg, Jesse Mager, Mary E. Dickinson, Lauryl M. J. Nutter, Violeta Muñoz-Fuentes, Chih-Wei Hsu, Ignatia B. Van den Veyver, Ann M. Flenniken, Colin McKerlie, Stephen A. Murray, Lydia Teboul, Jason D. Heaney, K. C. Kent Lloyd, Louise Lanoue, Robert E. Braun, Jacqueline K. White, Amie K. Creighton, Valerie Laurin, Ruolin Guo, Dawei Qu, Sara Wells, James Cleak, Rosie Bunton-Stasyshyn, Michelle Stewart, Jackie Harrisson, Jeremy Mason, Hamed Haseli Mashhadi, Helen Parkinson, Ann-Marie Mallon, International Mouse Phenotyping Consortium, Genomics England Research Consortium, Damian Smedley
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is p
Externí odkaz:
https://doaj.org/article/412d46fbccfd45569d9db0ede072d45d
Autor:
Panpan Zhao, Huanan Wang, Han Wang, Yanna Dang, Lei Luo, Shuang Li, Yan Shi, Lefeng Wang, Shaohua Wang, Jesse Mager, Kun Zhang
Publikováno v:
Epigenetics, Vol 15, Iss 4, Pp 369-385 (2020)
Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development. Incomplete epigenetic reprogramming is a major factor leading to poor d
Externí odkaz:
https://doaj.org/article/00a8becacb3c4b52b96bef8a2661cecc
Autor:
Oladele A. Oluwayiose, Chelsea Marcho, Haotian Wu, Emily Houle, Stephen A. Krawetz, Alexander Suvorov, Jesse Mager, J. Richard Pilsner
Publikováno v:
Environment International, Vol 155, Iss , Pp 106693- (2021)
Preconception environmental conditions have been demonstrated to shape sperm epigenetics and subsequently offspring health and development. Our previous findings in humans showed that urinary anti-androgenic phthalate metabolites in males were associ
Externí odkaz:
https://doaj.org/article/d1475a9a8bfd471eae1ef72b990d3320
Autor:
Feng Wang, Maria Gracia Gervasi, Ana Bošković, Fengyun Sun, Vera D Rinaldi, Jun Yu, Mary C Wallingford, Darya A Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J Rando, Pablo E Visconti, Lara Strittmatter, Ingolf Bach
Publikováno v:
eLife, Vol 10 (2021)
The X-linked gene Rlim plays major roles in female mouse development and reproduction, where it is crucial for the maintenance of imprinted X chromosome inactivation in extraembryonic tissues of embryos. However, while females carrying a systemic Rli
Externí odkaz:
https://doaj.org/article/85c0317343a64841b13715f36fcb3890
Autor:
Felipe A. Navarrete, Luis Aguila, David Martin-Hidalgo, Darya A. Tourzani, Guillermina M. Luque, Goli Ardestani, Francisco A. Garcia-Vazquez, Lonny R. Levin, Jochen Buck, Alberto Darszon, Mariano G. Buffone, Jesse Mager, Rafael A. Fissore, Ana M. Salicioni, María G. Gervasi, Pablo E. Visconti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
To become fertile, mammalian sperm must undergo a series of biochemical and physiological changes known as capacitation. These changes involve crosstalk between metabolic and signaling pathways and can be recapitulated in vitro. In this work, sperm w
Externí odkaz:
https://doaj.org/article/af4cb4f6880f4b7da14515482743cf71
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219410 (2019)
Despite having been sequenced over a decade ago, the functional significance of much of the mammalian genome remains unknown. The mouse has become the preeminent mammalian model for identifying endogenous gene function in vivo. Here we characterize t
Externí odkaz:
https://doaj.org/article/42eb497b10eb4aafbe204c10e99763a7
Autor:
Kaveh Daneshvar, Joshua V. Pondick, Byeong-Moo Kim, Chan Zhou, Samuel R. York, Jillian A. Macklin, Ameed Abualteen, Bo Tan, Alla A. Sigova, Chelsea Marcho, Kimberly D. Tremblay, Jesse Mager, Michael Y. Choi, Alan C. Mullen
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 353-365 (2016)
Long noncoding RNAs (lncRNAs) exhibit diverse functions, including regulation of development. Here, we combine genome-wide mapping of SMAD3 occupancy with expression analysis to identify lncRNAs induced by activin signaling during endoderm differenti
Externí odkaz:
https://doaj.org/article/d1c24d737caa44a189041171a0aafe38
Autor:
Siyeon Rhee, Mara-Isel Guerrero-Zayas, Mary C Wallingford, Pablo Ortiz-Pineda, Jesse Mager, Kimberly D Tremblay
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58828 (2013)
Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during the peri-implantation stage. To assess the post-gastrulation role of YY1, a conditional knock-out (cKO) strategy was used to delete YY1 from the visceral endoderm of the
Externí odkaz:
https://doaj.org/article/b69b57e2f8dc418d9abda82b5934d6ab
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22516 (2011)
Preimplantation is a dynamic developmental period during which a combination of maternal and zygotic factors program the early embryo resulting in lineage specification and implantation. A reverse genetic RNAi screen in mouse embryos identified the W
Externí odkaz:
https://doaj.org/article/6379860e08ba462c955118efc3a4f1d8