Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jesse L, Cox"'
Autor:
Ayoola O. Ogunleye, Neelanjana Gayen, Sanchita Rauth, Saravanakumar Marimuthu, Rama Krishna Nimmakayala, Zahraa W. Alsafwani, Jesse L. Cox, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Background PAF1/PD2 deregulation contributes to tumorigenesis, drug resistance, and cancer stem cell maintenance in Pancreatic Cancer (PC). Recent studies demonstrate that metabolic reprogramming plays a role in PC progression, but the mecha
Externí odkaz:
https://doaj.org/article/3ef116e6ac1745ca95ccd797415b56f9
Autor:
Pranita Atri, Ashu Shah, Gopalakrishnan Natarajan, Satyanarayana Rachagani, Sanchita Rauth, Koelina Ganguly, Joseph Carmicheal, Dario Ghersi, Jesse L. Cox, Lynette M. Smith, Maneesh Jain, Sushil Kumar, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real-w
Externí odkaz:
https://doaj.org/article/27698b79b7aa49419b969e281158a44b
Autor:
Ashu Shah, Sanjib Chaudhary, Imayavaramban Lakshmanan, Abhijit Aithal, Sophia G. Kisling, Claire Sorrell, Saravanakumar Marimuthu, Shailendra K. Gautam, Sanchita Rauth, Prakash Kshirsagar, Jesse L. Cox, Gopalakrishnan Natarajan, Rakesh Bhatia, Kavita Mallya, Satyanarayana Rachagani, Mohd Wasim Nasser, Apar Kishor Ganti, Ravi Salgia, Sushil Kumar, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-16 (2023)
Abstract Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor prognosis and lethality of pancreatic (PC) and non-small cell lung cancer (NSC
Externí odkaz:
https://doaj.org/article/32f677e6e7f342b1a84bc4cad2938d3b
Autor:
Rama Krishna Nimmakayala, Ayoola O. Ogunleye, Seema Parte, Nivedeta Krishna Kumar, Pratima Raut, Venkatesh Varadharaj, Naveen Kumar Perumal, Palanisamy Nallasamy, Sanchita Rauth, Jesse L. Cox, Subodh M. Lele, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-12 (2022)
Abstract Acinar-to-ductal metaplasia (ADM) is a precursor lesion of pancreatic ductal adenocarcinoma (PDAC); however, the regulators of the ADM-mediated PDAC development and its targeting are poorly understood. RNA polymerase II-associated factor 1 (
Externí odkaz:
https://doaj.org/article/7a84fef653ec44ccac54817f42b4f6e8
Autor:
Chitra Palanivel, Neha Chaudhary, Parthasarathy Seshacharyulu, Jesse L. Cox, Ying Yan, Surinder K. Batra, Michel M. Ouellette
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 25, Iss , Pp 28-40 (2022)
Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene. In pancreatic cancer (PC), more than 90% of tumors carry an act
Externí odkaz:
https://doaj.org/article/fecd7e5ec4184873b2e9116838a95734
Autor:
Sanchita Rauth, Koelina Ganguly, Pranita Atri, Seema Parte, Rama Krishna Nimmakayala, Venkatesh Varadharaj, Palanisamy Nallasamy, Raghupathy Vengoji, Ayoola O. Ogunleye, Imayavaramban Lakshmanan, Ramakanth Chirravuri, Mika Bessho, Jesse L. Cox, Jason M. Foster, Geoffrey A. Talmon, Tadayoshi Bessho, Apar Kishor Ganti, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112043- (2023)
Summary: Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common
Externí odkaz:
https://doaj.org/article/54869e1709fb4e06a58c522c9efae474
Autor:
Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter, Angie Rizzino
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could he
Externí odkaz:
https://doaj.org/article/b53a1360cbb5429d91603e9c267a376e
Autor:
Ramesh Pothuraju, Satyanarayana Rachagani, Shiv Ram Krishn, Sanjib Chaudhary, Rama Krishna Nimmakayala, Jawed A. Siddiqui, Koelina Ganguly, Imayavaramban Lakshmanan, Jesse L. Cox, Kavita Mallya, Sukhwinder Kaur, Surinder K. Batra
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-14 (2020)
Abstract Background Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, whereas its aberrant
Externí odkaz:
https://doaj.org/article/3d4b4960fd4b40c8a7f09769e7eea41d
Autor:
Prasanta K. Dash, Fadhel A. Alomar, Jesse L. Cox, JoEllyn McMillan, Bryan T. Hackfort, Edward Makarov, Brenda Morsey, Howard S. Fox, Howard E. Gendelman, Santhi Gorantla, Keshore R. Bidasee
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg-Pr
Externí odkaz:
https://doaj.org/article/4f2a27b9809f46c2b078238674c554a2
Autor:
Rakesh Bhatia, Jawed Akhtar Siddiqui, Koelina Ganguly, Christopher M. Thompson, Andrew Cannon, Abhijit Aithal, Naveenkumar Perumal, Shailendra K. Maurya, Xiaoqi Li, Jesse L. Cox, Channabasavaiah B. Gurumurthy, Satyanarayana Rachagani, Maneesh Jain, Mohd Wasim Nasser, Surinder K. Batra, Sushil Kumar
Publikováno v:
Oncogene. 42:759-770
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a90afe6daa9fa7a98fc067218ef5da3
https://doi.org/10.1038/s41388-022-02587-1
https://doi.org/10.1038/s41388-022-02587-1