Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Jesse J. Smith"'
Autor:
Arlee V. Smith, Jesse J. Smith
Publikováno v:
IEEE Photonics Journal, Vol 5, Iss 5, Pp 7100807-7100807 (2013)
We estimate the Stokes wave starting power for stimulated thermal Rayleigh scattering (STRS) produced by thermal fluctuations in the fiber core that transiently alter the refractive index profile in the core. A transverse temperature gradient creates
Externí odkaz:
https://doaj.org/article/a1fb936d8b0c4ad9b144256a2e905454
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ead92a929cc4e895624b9120695df
https://doi.org/10.1158/1535-7163.22499889.v1
https://doi.org/10.1158/1535-7163.22499889.v1
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f0193e841ebe292cdd7fd3a4087a01
https://doi.org/10.1158/1535-7163.c.6537771.v1
https://doi.org/10.1158/1535-7163.c.6537771.v1
Autor:
Michael J. Thomenius, Alejandra Raimondi, Scott A. Ribich, Sarah K. Knutson, Elayne Chan-Penebre, Heike Keilhack, Robert A. Copeland, Jesse J. Smith, Christopher Plescia, Igor Feldman, Natalie M. Warholic, Vinny Motwani, Trupti Lingaraj, Allison Drew, Danielle Johnston-Blackwell, Dorothy Brach
The EZH2 small-molecule inhibitor tazemetostat (EPZ-6438) is currently being evaluated in phase II clinical trials for the treatment of non-Hodgkin lymphoma (NHL). We have previously shown that EZH2 inhibitors display an antiproliferative effect in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16635ec96cb32a617f49970fa6370768
https://doi.org/10.1158/1535-7163.c.6539623.v1
https://doi.org/10.1158/1535-7163.c.6539623.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 811K, Fig. S1. Effects of EPZ-6438 on Gene Promoter H3K27 Methylation, Recruitment of PRC2 Components to Gene Promoters, and Cell Cycle, in WSU-DLCL2 Cells. Fig. S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fcbfa5d3e9bdddeac3c8f600a70bce
https://doi.org/10.1158/1535-7163.22499898.v1
https://doi.org/10.1158/1535-7163.22499898.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 25K, Table S1: LCC Values for EPZ-6438 for WSU-DLCL2 Human Lymphoma Cells Dosed Either Continuously or After Compound Washout.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12304f9a85f43c2b5fe15a51c85b039b
https://doi.org/10.1158/1535-7163.22499892
https://doi.org/10.1158/1535-7163.22499892
Autor:
Scott R. Daigle, Kathrin M. Bernt, Stephen J. Blakemore, Robert A. Copeland, Jesse J. Smith, Roy M. Pollock, Edward J. Olhava, Nigel J. Waters, Taylor Yamauchi, Michael J. Maria, Ty M. Thomson, David A. Drubin, Jessica N. Haladyna, Carly T. Campbell
Contains the mechanism footprint gene list referenced by supplemental Table S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b27a0f3e74bce3707a37643b0d7252
https://doi.org/10.1158/1535-7163.22508665.v1
https://doi.org/10.1158/1535-7163.22508665.v1
Autor:
Michael J. Thomenius, Alejandra Raimondi, Scott A. Ribich, Sarah K. Knutson, Elayne Chan-Penebre, Heike Keilhack, Robert A. Copeland, Jesse J. Smith, Christopher Plescia, Igor Feldman, Natalie M. Warholic, Vinny Motwani, Trupti Lingaraj, Allison Drew, Danielle Johnston-Blackwell, Dorothy Brach
Table S1: Conditions and seeding densities of all cell lines used in studies; Table S2. Single agent IC50 values for agents tested for 3 days in 96-well plates as described in Materials and Methods; Figure S1. Tazemetostat dosing reduced H3K27me3 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028053566081cf3c139a50ed258075a7
https://doi.org/10.1158/1535-7163.22510432
https://doi.org/10.1158/1535-7163.22510432
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
Mutations within the catalytic domain of the histone methyltransferase EZH2 have been identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic alterations are hypothesized to confer an oncogenic dependency on EZH2 enzymatic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9ced2f5eb38e4c70192dc2fd63ef50
https://doi.org/10.1158/1535-7163.c.6536301
https://doi.org/10.1158/1535-7163.c.6536301
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
PDF File -1 MB, Supplemental data is to further support the statements made it the main text. Captions: Supplemental Table 1: Cell Lines used in the CRISPR pooled screen. Supplemental Table 2: Table of ovarian lines screened for tazemetostat sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28078359a52e1425c550d2baf2f9465b
https://doi.org/10.1158/1535-7163.22504545
https://doi.org/10.1158/1535-7163.22504545