Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway

Autor: Kara Hoar, Jiejin Chen, Sean J. Harrison, Jingya Ma, James M. Gavin, Neil F. Bence, Wei Chen, Ping Li, Michael Sintchak, Nancy J. Bump, Qing Xu, Lawrence R. Dick, William D. Mallender, Jesse J. Chen, Alexandra E. Gould, Frank Bruzzese, Yafang Lin

Publikováno v: Journal of Biological Chemistry. 289:22648-22658

E1 enzymes activate ubiquitin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascade of Ubl conjugation to target proteins or lipids. Ubiquitin-fold modifier 1 (Ufm1) is activated by the E1 enzyme Uba5, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6849a9cf4d33b291a3a2b8282c7b575a
https://doi.org/10.1074/jbc.m114.573972

Experience of the first adult-focussed undiagnosed disease program in Australia (AHA-UDP): solving rare and puzzling genetic disorders is ageless.

Autor: Wallis M; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Tasmanian Clinical Genetics Service, Tasmanian Health Service, Hobart, TAS, Australia.; School of Medicine and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia., Bodek SD; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia. simon.bodek@austin.org.au.; Medicine, Dentistry and Health Science, The University of Melbourne, Parkville, Australia. simon.bodek@austin.org.au., Munro J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Rafehi H; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Bennett MF; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia.; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia., Ye Z; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia., Schneider A; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia., Gardiner F; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia., Valente G; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia., Murdoch E; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia., Uebergang E; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Parkville, Australia., Hunter J; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia., Stutterd C; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Victorian Clinical Genetics Service, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Huq A; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Genetic Medicine Service, The Royal Melbourne Hospital, Melbourne, Australia., Salmon L; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Genetics Service, Royal Prince Alfred Hospital, Melbourne, Australia., Scheffer I; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia.; Department of Paediatrics, Austin Health, Melbourne, Australia., Eratne D; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia.; Neuropsychiatry, The Royal Melbourne Hospital, Melbourne, Australia., Meyn S; Centre for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA., Fong CY; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia., John T; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Medicine, Dentistry and Health Science, The University of Melbourne, Parkville, Australia.; Peter MacCallum Cancer Centre, Melbourne, Australia., Mullen S; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia., White SM; Victorian Clinical Genetics Service, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Brown NJ; Victorian Clinical Genetics Service, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., McGillivray G; Victorian Clinical Genetics Service, Melbourne, Australia.; Genetics Service, Mercy Hospital for Women, Melbourne, Australia., Chen J; Neurology Service, Austin Health, Melbourne, Australia., Richmond C; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Hughes A; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Medicine, Dentistry and Health Science, The University of Melbourne, Parkville, Australia., Krzesinski E; Monash Health Genetics Clinic, Melbourne, Australia., Fennell A; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Monash Health Genetics Clinic, Melbourne, Australia., Chambers B; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Medicine, Dentistry and Health Science, The University of Melbourne, Parkville, Australia., Santoreneos R; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Victorian Clinical Genetics Service, Melbourne, Australia., Le Fevre A; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Victorian Clinical Genetics Service, Melbourne, Australia., Hildebrand MS; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia., Bahlo M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia., Christodoulou J; Victorian Clinical Genetics Service, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Delatycki M; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Victorian Clinical Genetics Service, Melbourne, Australia.; Murdoch Children's Research Institute, Melbourne, Parkville, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Berkovic SF; Austin Health Clinical Genetics Service, Austin Health, Melbourne, Australia.; Epilepsy Research Centre, University of Melbourne, Austin Health, Melbourne, Australia.

Publikováno v: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2024 Aug 02; Vol. 19 (1), pp. 288. Date of Electronic Publication: 2024 Aug 02.

A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation.

Autor: Wang SH; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA. shidasui@umich.edu.; Division of Allergy, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. shidasui@umich.edu., Cao Z; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA., Farazuddin M; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA.; Division of Allergy, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Chen J; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA., Janczak KW; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA., Tang S; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA., Cannon J; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA., Baker JR Jr; Michigan Nanotechnology Institute for Medicine and Biological Sciences, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA.; Division of Allergy, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

Publikováno v: Cancer gene therapy [Cancer Gene Ther] 2024 Mar; Vol. 31 (3), pp. 464-471. Date of Electronic Publication: 2024 Jan 04.

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders.

Autor: Gadiyar V; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States., Patel G; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States., Chen J; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Vigil D; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Ji N; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Campbell V; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Sharma K; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Shi Y; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Weiss MM; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Birge RB; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States., Davra V; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jul 20; Vol. 14, pp. 1135373. Date of Electronic Publication: 2023 Jul 20 (Print Publication: 2023).

Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion.

Autor: Chen J; Department of Internal Medicine, Division of Allergy, Michigan Nanotechnology, Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA., Cao Z; Department of Internal Medicine, Division of Allergy, Michigan Nanotechnology, Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA., Cannon J; Department of Internal Medicine, Division of Allergy, Michigan Nanotechnology, Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA., Fan Y; Department of Internal Medicine, Division of Allergy, Michigan Nanotechnology, Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA., Baker JR Jr; Department of Internal Medicine, Division of Allergy, Michigan Nanotechnology, Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA., Wang SH; Department of Internal Medicine, Division of Allergy, Michigan Nanotechnology, Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan, USA.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2022 Apr 27; Vol. 10 (2), pp. e0250621. Date of Electronic Publication: 2022 Apr 12.