Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jesse Hudson"'
Autor:
Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Abstract Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate
Externí odkaz:
https://doaj.org/article/3438a5e4c9ae4d46bf14a48ac898942d
Autor:
Eduardo Cepeda Cañedo, Stephanie Totten, Ryuhjin Ahn, Paul Savage, Deanna MacNeil, Jesse Hudson, Chantal Autexier, Genevieve Deblois, Morag Park, Michael Witcher, Josie Ursini-Siegel
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
Triple-negative breast cancers (TNBCs) lack effective targeted therapies, and cytotoxic chemotherapies remain the standard of care for this subtype. Owing to their increased genomic instability, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi)
Externí odkaz:
https://doaj.org/article/96aa4977e46346acb779cdd5bbcf3cf3
Autor:
Josie Ursini-Siegel, Morag Park, Paul Savage, Jesse Hudson, Geneviève Deblois, Chantal Autexier, Deanna Elise MacNeil, Eduardo Cepeda Cañedo, Ryuhjin Ahn, Stephanie Totten, Michael Witcher
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 4 (2021)
JCI Insight, Vol 6, Iss 4 (2021)
Triple-negative breast cancers (TNBCs) lack effective targeted therapies, and cytotoxic chemotherapies remain the standard of care for this subtype. Owing to their increased genomic instability, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f95d98d0b68f2f57cd15f58ebb37b
https://pubmed.ncbi.nlm.nih.gov/33470989
https://pubmed.ncbi.nlm.nih.gov/33470989
Autor:
Mathieu Lajoie, Ryuhjin Ahn, Jesse Hudson, Ian R. Watson, Sébastien Tabariès, Peter M. Siegel, Eduardo Cepeda Cañedo, Rachel La Selva, Claire M. Brown, Julien Senecal, Valerie Sabourin, Josie Ursini-Siegel, Matthew J. Siegel, Elena Voorand, Brian E. Hsu, Matthew Dankner, Alex Kiepas, Kyle Lewis, Jacqueline R. Ha, Matthew G. Annis
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f1f183a688a8be5016364492f4c75
https://doi.org/10.1186/s13058-020-1245-6
https://doi.org/10.1186/s13058-020-1245-6
Autor:
Ouafa Najyb, Ryuhjin Ahn, Daina Avizonis, Josie Ursini-Siegel, Tony Pawson, Young Kyuen Im, Shawn McGuirk, Valerie Sabourin, Valérie Chénard, Julie St-Pierre, Michael Pollak, Jesse Hudson, Ivan Topisirovic, Simon-Pierre Gravel
Publikováno v:
Cancer research. 78(17)
The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf7ced3fcf067d50e1623a5f247fe15
https://pubmed.ncbi.nlm.nih.gov/29930100
https://pubmed.ncbi.nlm.nih.gov/29930100
Autor:
Julien Senecal, Jesse Hudson, Valérie Sabourin, Rachel La Selva, Ryuhjin Ahn, Kyle Lewis, Giuseppina Ursini-Siegel, Sébastien Tabariès, Alexander Kiepas, Peter M. Siegel
Publikováno v:
Cancer Research. 78:21-21
Introduction: Src homology and collagen A (ShcA) adaptor proteins are essential during breast cancer progression. However, the role of the largest isoform, p66ShcA, is conflicting and still poorly understood. Under high levels of stress p66ShcA is ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8688397bd08b2bdf119d1f0e57fc048d
https://doi.org/10.1158/1538-7445.am2018-21
https://doi.org/10.1158/1538-7445.am2018-21
Autor:
Lauren Podmore, Josie Ursini-Siegel, Nicole Beauchemin, Laura Forrest, Jacqueline R. Ha, Julie Livingstone, Ryuhjin Ahn, Jennifer F. Knight, Valerie Sabourin, Jesse Hudson, Michael Hallett, Rachel La Selva, Morag Park
Publikováno v:
Molecular and cellular biology. 34(19)
Breast cancers are stratified into distinct subtypes, which influence therapeutic responsiveness and patient outcome. Patients with luminal breast cancers are often associated with a better prognosis relative to that with other subtypes. However, sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a9944c08644e2597ce92b3279dfb9d
https://pubmed.ncbi.nlm.nih.gov/25071152
https://pubmed.ncbi.nlm.nih.gov/25071152