Presenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells Upon Elevated Glucose

Autor: Christiane Klec, Corina T. Madreiter-Sokolowski, Gabriela Ziomek, Sarah Stryeck, Vinay Sachdev, Madalina Duta-Mare, Benjamin Gottschalk, Maria R. Depaoli, Rene Rost, Jesse Hay, Markus Waldeck-Weiermair, Dagmar Kratky, Tobias Madl, Roland Malli, Wolfgang F. Graier

Publikováno v: Cellular Physiology and Biochemistry, Vol 53, Iss 3, Pp 573-586 (2019)

Externí odkaz: https://doaj.org/article/ecefd430b6a34c7c87fe3eda572a590f

Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells

Autor: Christiane, Klec, Corina T, Madreiter-Sokolowski, Sarah, Stryeck, Vinay, Sachdev, Madalina, Duta-Mare, Benjamin, Gottschalk, Maria R, Depaoli, Rene, Rost, Jesse, Hay, Markus, Waldeck-Weiermair, Dagmar, Kratky, Tobias, Madl, Roland, Malli, Wolfgang F, Graier

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Background/Aims In pancreatic β-cells, the intracellular Ca2+ homeostasis is an essential regulator of the cells’ major functions. The endoplasmic reticulum (ER) as interactive intracellular Ca2+ store balances cellular Ca2+. In this study basal E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6e2ca30ee07eaf1da642b11d7f441e
https://pubmed.ncbi.nlm.nih.gov/30790505