Zobrazeno 1 - 2
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pro vyhledávání: '"Jesse G. Chapman"'
Publikováno v:
The Journal of Biological Chemistry
Cytochrome P450 (P450) 3A4 is the enzyme most involved in the metabolism of drugs and can also oxidize numerous steroids. This enzyme is also involved in one-half of pharmacokinetic drug–drug interactions, but details of the exact mechanisms of P45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c374ce6dab0046618d2955583b1acc6
https://pubmed.ncbi.nlm.nih.gov/33449875
https://pubmed.ncbi.nlm.nih.gov/33449875
Publikováno v:
The Journal of Biological Chemistry
Cytochrome P450 (P450) 17A1 catalyzes the 17α-hydroxylation of progesterone and pregnenolone as well as the subsequent lyase cleavage of both products to generate androgens. However, the selective inhibition of the lyase reactions, particularly with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce22af5eca53b1aaba935d18335793d
https://doi.org/10.1016/j.jbc.2021.100969
https://doi.org/10.1016/j.jbc.2021.100969