Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jesse E. Hanson"'
Autor:
Yi Lu, Longyu Mu, Justin Elstrott, Chaoying Fu, Cailu Sun, Tonghui Su, Xiaofan Ma, Jia Yan, Hong Jiang, Jesse E. Hanson, Yang Geng, Yelin Chen
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105045- (2024)
Summary: Background: Schizophrenia, a debilitating psychiatric disorder, displays considerable interindividual variation in clinical presentations. The ongoing debate revolves around whether this heterogeneity signifies a continuum of severity linked
Externí odkaz:
https://doaj.org/article/cbaf650e8efe4b698fad41585b8367f6
Autor:
Jesse E. Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Abdullah S. Khan, Jeffrey Simms, Benjamin Liu, Thomas A. Kim, Gui-Qiu Yu, Yelin Chen, Tzu-Ming Wang, Zhiyu Jiang, Bianca M. Liederer, Gauri Deshmukh, Hilda Solanoy, Connie Chan, Benjamin D. Sellers, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Robby M. Weimer, Morgan Sheng, T. Michael Gill, Kimberly Scearce-Levie, Jorge J. Palop
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 381-396.e4 (2020)
Summary: NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR
Externí odkaz:
https://doaj.org/article/086ee7e911424901b05bcdfb74e615c9
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a fin
Externí odkaz:
https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a6
Autor:
Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2111-2123.e6 (2019)
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focuse
Externí odkaz:
https://doaj.org/article/6cf938f6916a4deca5b7f57d27bda622
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 254-262 (2015)
GluN2B subunit containing NMDARs (GluN2B-NMDARs) mediate pathophysiological effects of acutely applied amyloid beta (Aβ), including impaired long-term potentiation (LTP). However, in transgenic Alzheimer's disease (AD) mouse models which feature gra
Externí odkaz:
https://doaj.org/article/e2d55adc4687495981e5ce9ada8619a3
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article omitted the middle initial of the author Jesse E. Hanson. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/1911f107c7844befa31fd140e1b5cd67
Autor:
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Nature Aging. 2:837-850
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependen
Autor:
Yuanyuan Wang, Martin Weber, Oded Foreman, Helga Remy, Eva Zsuzsanna Mracsko, Jesse E. Hanson
Publikováno v:
Science Translational Medicine. 15
We highlight potential issues with a Western blot assay using mouse anti–caspase-1 antibody to detect cleaved caspase-1 p20 subunit in mouse brain tissue lysates.
Autor:
Jiechao Zhou, Sarah D. Wade, David Graykowski, Mei-Fang Xiao, Binhui Zhao, Lucia A. A. Giannini, Jesse E. Hanson, John C. van Swieten, Morgan Sheng, Paul F. Worley, Borislav Dejanovic
Publikováno v:
Science Translational Medicine. 15(689)
Complement overactivation mediates microglial synapse elimination in neurological diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identif
Autor:
Yuanyuan Wang, Tiffany Wu, Ming-Chi Tsai, Mitchell G Rezzonico, Alyaa M Abdel-Haleem, Luke Xie, Vineela D Gandham, Hai Ngu, Kimberly Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A Friedman, Morgan Sheng, Jesse E Hanson
TPL2 (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and is required for microglia-mediated neuron deathin vitro. In acutein vivoneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fc4ffd68bf6c136e87a0857d07f9a45
https://doi.org/10.1101/2022.10.13.512193
https://doi.org/10.1101/2022.10.13.512193