Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jesse Donovan"'
Autor:
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Externí odkaz:
https://doaj.org/article/76d21e2f20924475a4c47cb697a95a92
Autor:
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss
Publikováno v:
eLife, Vol 6 (2017)
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Externí odkaz:
https://doaj.org/article/10892b8d0012417b8d9719dca9a847cd
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 902-913 (2012)
2′,5′-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2-5As induce self-association and activation of RNase L, which cleaves cytosolic RNA and promotes the production of int
Externí odkaz:
https://doaj.org/article/61d4314c8aa645cda2f77d21e8636b02
Autor:
Jesse Donovan, Paul R Copeland
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35581 (2012)
The amino acid selenocysteine (Sec) is encoded by UGA codons. Recoding of UGA from stop to Sec requires a Sec insertion sequence (SECIS) element in the 3' UTR of selenoprotein mRNAs. SECIS binding protein 2 (SBP2) binds the SECIS element and is essen
Externí odkaz:
https://doaj.org/article/4c85b1932a1b4f4aafd6073d17dddd2b
Autor:
Susan R. Weiss, Sneha Rath, Sergei V. Kotenko, Kaitlin Demarest, Ned S. Wingreen, Alisha Chitrakar, Alexei Korennykh, Jesse Donovan, Raghavendra Rao Sridhar, Yize Li
Publikováno v:
Proceedings of the National Academy of Sciences
Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/endoribonuclease RNase L. RNase L executes regulated RNA decay and halts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f342e8cf6dcb39b252b32364fcb36d9e
https://doi.org/10.1073/pnas.1818363116
https://doi.org/10.1073/pnas.1818363116
Autor:
Jesse Donovan, Yigal Meir, Kaitlin Demarest, Alexei Korennykh, Sneha Rath, Eliza Prangley, Ned S. Wingreen
RNA degradation by RNase L during 2-5A-mediated decay (2-5AMD) is a conserved mammalian stress response to viral and endogenous double-stranded RNA (dsRNA). 2-5AMD onsets rapidly and facilitates a switch of protein synthesis from homeostasis to produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc2c76135d91d8f9851861b14727206
Autor:
Sneha Rath, Raghavendra Rao Sridhar, Jesse Donovan, Alisha Chitrakar, Ned S. Wingreen, Sergei V. Kotenko, Susan R. Weiss, Alexei Korennykh, Yize Li, Kaitlin Demarest
Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously expressed pseudokinase/endoribonuclease RNase L. RNase L executes regulated RNA decay and halts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4fee6a3941abf5abe0aa5f92ded0df
Publikováno v:
Proceedings of the National Academy of Sciences. 112:3949-3954
The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2',5'-linked RNA molecules (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c49ec892352a8d4db1098ac0d8d3108
https://doi.org/10.1073/pnas.1419409112
https://doi.org/10.1073/pnas.1419409112
Mammalian cells respond to double-stranded RNA (dsRNA) by activating a translation-inhibiting endoribonuclease, RNase L. Consensus in the field indicates that RNase L arrests protein synthesis by degrading ribosomal RNAs (rRNAs) and messenger RNAs (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7b15c54b15a0d8fa38a565dbcd5ad6
https://europepmc.org/articles/PMC5648034/
https://europepmc.org/articles/PMC5648034/
Autor:
Wendy Wing Yee Au, Samantha R. Oakes, Belinda Whittle, Jesse Donovan, Matthew J. Naylor, Christopher J. Ormandy, Zoya Kikhtyak, David Gallego-Ortega, Andrew M. K. Law, Stephanie L. Allerdice, Adelaide I. J. Young, Christopher C. Goodnow, Simon Junankar, Anita von Korff, Claudio M Sergio, Edward M. Bertram, Moira K O'Bryan, Lesley Castillo, Catherine L. Piggin, Daniel L. Roden, Prudence M Stanford, Alexei Korennykh
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
PLoS Genetics, Vol 13, Iss 11, p e1007072 (2017)
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536ed1c723b111319265e7046d2dee2b
http://europepmc.org/articles/PMC5695588
http://europepmc.org/articles/PMC5695588