Pathophysiologic and transcriptomic analyses of viscerotropic yellow fever in a rhesus macaque model.

Autor: Flora Engelmann, Laurence Josset, Thomas Girke, Byung Park, Alex Barron, Jesse Dewane, Erika Hammarlund, Anne Lewis, Michael K Axthelm, Mark K Slifka, Ilhem Messaoudi

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3295 (2014)

Infection with yellow fever virus (YFV), an explosively replicating flavivirus, results in viral hemorrhagic disease characterized by cardiovascular shock and multi-organ failure. Unvaccinated populations experience 20 to 50% fatality. Few studies ha

Externí odkaz: https://doaj.org/article/dec00f1f7e03413fb14a8d111ccfd288

Age and Immune Status of Rhesus Macaques Impact Simian Varicella Virus Gene Expression in Sensory Ganglia

Autor: Kristen Haberthur, Amelia Kerns, Ilhem Messaoudi, Alex Barron, Byung Park, Christine Meyer, Jesse Dewane

Publikováno v: Journal of Virology. 87:8294-8306

Simian varicella virus (SVV) infection of rhesus macaques (RMs) recapitulates the hallmarks of varicella-zoster virus (VZV) infection of humans, including the establishment of latency within the sensory ganglia. Various factors, including age and imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc775a7d98c50048ea606cf6faf89b28
https://doi.org/10.1128/jvi.01112-13

Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques

Autor: Ilhem Messaoudi, Charles R. Thomas, W Laub, Joshua M. Walker, S Pillai, Flora Engelmann, Jesse Dewane, Christine Meyer

Publikováno v: Clinical and experimental immunology. 181(3)

Summary In this study we examined the effects of non-myeloablative total body irradiation (TBI) in combination with immunosuppressive chemotherapy on immune homeostasis in rhesus macaques. Our results show that the administration of cyclosporin A or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8928b6afab6375f70bc35b6c07f04ec2
https://pubmed.ncbi.nlm.nih.gov/25902927

Pathophysiologic and transcriptomic analyses of viscerotropic yellow fever in a rhesus macaque model

Autor: Ilhem Messaoudi, Alex Barron, Thomas Girke, Jesse Dewane, Byung Park, Flora Engelmann, Anne D. Lewis, Michael K. Axthelm, Erika Hammarlund, Laurence Josset, Mark K. Slifka

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3295 (2014)

Infection with yellow fever virus (YFV), an explosively replicating flavivirus, results in viral hemorrhagic disease characterized by cardiovascular shock and multi-organ failure. Unvaccinated populations experience 20 to 50% fatality. Few studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43b211dc85a143aa0252a6b50facb40
https://pubmed.ncbi.nlm.nih.gov/25412185

Bacterial artificial chromosome derived simian varicella virus is pathogenic in vivo

Autor: Flora Engelmann, Wayne L. Gray, Nicole Arnold, Christine Meyer, Jesse Dewane, Kristen Haberthur, Ilhem Messaoudi

Publikováno v: Virology Journal
Meyer, Christine; Dewane, Jesse; Haberthur, Kristen; Engelmann, Flora; Arnold, Nicole; Gray, Wayne; et al.(2013). Bacterial artificial chromosome derived simian varicella virus is pathogenic in vivo. Virology Journal, 10(1), 278. doi: http://dx.doi.org/10.1186/1743-422X-10-278. Retrieved from: http://www.escholarship.org/uc/item/83m8n3zw

Background Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus that infects humans and results in chickenpox and herpes zoster. A number of VZV genes remain functionally uncharacterized and since VZV is an obligate human pathogen, rigorous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee1590256923ff3569e604abf065cdc