Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jesse D. Vargas"'
Autor:
Amy K. LeBlanc, Christina N. Mazcko, Timothy M. Fan, David M. Vail, Brian K. Flesner, Jeffrey N. Bryan, Shan Li, Feng Wang, Scott Harris, Jesse D. Vargas, Jeevan P. Govindharajulu, Soumya Jaganathan, Francesca Tomaino, Apurva K. Srivastava, Tsui-Fen Chou, Gordon M. Stott, Joseph M. Covey, Barbara Mroczkowski, James H. Doroshow
Publikováno v:
Mol Cancer Ther
Pet dogs with naturally occurring cancers play an important role in studies of cancer biology and drug development. We assessed tolerability, efficacy, and pharmacokinetic/pharmacodynamic relationships with a first-in-class small molecule inhibitor o
Autor:
James H. Doroshow, Barbara Mroczkowski, Joseph M. Covey, Gordon M. Stott, Tsui-Fen Chou, Apurva K. Srivastava, Francesca Tomaino, Soumya Jaganathan, Jeevan P. Govindharajulu, Jesse D. Vargas, Scott Harris, Feng Wang, Shan Li, Jeffrey N. Bryan, Brian K. Flesner, David M. Vail, Timothy M. Fan, Christina N. Mazcko, Amy K. LeBlanc
Supplementary Data from Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306d21372321eea9e3620f450a0deeda
https://doi.org/10.1158/1535-7163.22523473.v1
https://doi.org/10.1158/1535-7163.22523473.v1
Autor:
Krzysztof Palczewski, Alyaa Shmara, Timothy Ton, Cheng Cheng, Jesse D. Vargas, Marja Pitkänen, Virginia Kimonis, Lan Weiss, Teemu Turunen, Sama Saeid, Christopher L. Sander, Henri Leinonen, Lac Ta, Jianye Zhang, Ari Koskelainen
Publikováno v:
J Pharmacol Exp Ther
CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which phase I trials for cancer were terminated because of adverse effects on vision, such as photophobia and dyschromatopsia. Lower dose CB-5083 could combat inclusion body myopath
Autor:
Philip J Jensik, Jesse D Vargas, Sara N Reardon, Shivakumar Rajamanickam, Jodi I Huggenvik, Michael W Collard
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115908 (2014)
DEAF1 is a transcriptional regulator associated with autoimmune and neurological disorders and is known to bind TTCG motifs. To further ascertain preferred DEAF1 DNA ligands, we screened a random oligonucleotide library containing an "anchored" CpG m
Externí odkaz:
https://doaj.org/article/dc2ed74694934ff1882625223f66a904
Autor:
Amy Saur Conway, Lina Benajiba, Camille Vaganay, Daniel J. DeAngelo, Olivier Hermine, Yangzhong Tang, Kasper Lage, Han-Jie Zhou, Ilene Galinsky, Patrick Auberger, Jesse D. Vargas, Richard Stone, Josée Guirouilh-Barbat, Gabriela Alexe, Chaïma Benaksas, Yana Pikman, Alexandre Puissant, Bryann Pardieu, Daniel Anderson, Kimberly Stegmaier, Blandine Roux, Jana M. Ellegast, Bernard S. Lopez, Monica Schenone, Christina R. Hartigan, Michael T. Hemann, Linda Ross, Nina Fenouille, Mehdi Khaled, Frank Ling, Edyta Malolepsza, Frederic Luciano, Steven A. Carr, Gaetano Sodaro, Ronan Le Moigne, Tony Wu
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩
Sci Transl Med
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩
Sci Transl Med
The development and survival of cancer cells require adaptive mechanisms to stress. Such adaptations can confer intrinsic vulnerabilities, enabling the selective targeting of cancer cells. Through a pooled in vivo short hairpin RNA (shRNA) screen, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10c3d1c692e60e789dde8f10a34b3af
https://hal.archives-ouvertes.fr/hal-03420708
https://hal.archives-ouvertes.fr/hal-03420708
Autor:
Jesse D. Vargas, Kenny Lou, Kristy C. Perez, Han-Jie Zhou, Yangzhong Tang, Mary-Kamala Menon, Mark Rolfe, Ronan Le Moigne, Xianyun Jiao, Peter K Buchowiecki, Ariel Pios, Antonett Madriaga, Daniel Anderson, Grace J. Lee, Bing Yao, Laura K. Shawver, Zhi Yong Wu, Victoria A. Assimon
Publikováno v:
ACS chemical biology. 14(2)
RUVBL1 and RUVBL2 are ATPases associated with diverse cellular activities (AAAs) that form a complex involved in a variety of cellular processes, including chromatin remodeling and regulation of gene expression. RUVBLs have a strong link to oncogenes
Autor:
Eytan M. Stein, Amy Burroughs, Monic J. Stuart, Lina Benajiba, Nada Hamad, Courtney D. DiNardo, Hetty E. Carraway, Costas K. Yannakou, Jesse D. Vargas, Scott Harris, Kimberly Stegmaier, Dorothy Nguyen, Hayley Lane, Alexandre Puissant
Publikováno v:
Blood. 136:21-21
Background: Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are clonal hematopoietic disorders that predominantly occur in older adults. For a limited number of fit patients, induction followed by consolidation chemotherapy and/or all
Autor:
Gerard Kroon, Jesse D. Vargas, Holly E. Dembinski, Alexander Hoffmann, Nadja Kern, Elizabeth A. Komives, Kevin Wismer, Gajendra W. Suryawanshi, H. Jane Dyson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 8
Stress-response transcription factors such as NFκB turn on hundreds of genes and must have a mechanism for rapid cessation of transcriptional activation. We recently showed that the inhibitor of NFκB signaling, IκBα, dramatically accelerates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9473db45899433f4adc098776f7acc0
https://escholarship.org/uc/item/3tf7819h
https://escholarship.org/uc/item/3tf7819h
Publikováno v:
The Journal of Cell Biology
Formation of the nuclear envelope (NE) around segregated chromosomes occurs by the reshaping of the endoplasmic reticulum (ER), a reservoir for disassembled nuclear membrane components during mitosis. In this study, we show that inner nuclear membran
Publikováno v:
Wiley Interdiscip Rev Syst Biol Med
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, an