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pro vyhledávání: '"Jesse D. Combs"'
Autor:
Cecile Yu, Uwe Klein, Eric Fournier, Jesse D. Combs, Jacobsen John R, G. Roger Thomas, Juergen W. Pfeiffer, Edmund J. Moran, Seok-Ki Choi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1213-1218
A multivalent approach was applied to the design of long-acting inhaled β(2)-adrenoceptor agonists. A series of dimeric arylethanolamines based on the short acting β(2)-adrenoceptor agonist albuterol were prepared, varying the nature and length of
Autor:
Eric M. Gordon, Bruce P. England, Jesse D. Combs, Supriya Jonnalagadda, Dinesh V. Patel, Mikhail F. Gordeev
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:883-889
Solid-phase synthesis of a 300-member pharmacophore library of 1,4-dihydropyridines from keto ester, diketone and aldehyde building blocks on a cleavable amine polymeric support is described. Screening and serial deconvolution of the combinatorial li