Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jesse C. Cochrane"'
Autor:
Manashree Damle, Jesse C. Cochrane, Robert E. Kingston, Ethan Z. McCaslin, Sharon K. Marr, Theresa A. Oei, Elizabeth S. Jaensch, Jinjin Zhu
Publikováno v:
Mol Cell
The CBX family of proteins is central to proper mammalian development via key roles in Polycomb-mediated maintenance of repression. CBX proteins in differentiated lineages have chromatin compaction and phase separation activities that might contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90a61116f0cf2b6a6a8c2c92b20c804
https://europepmc.org/articles/PMC8966356/
https://europepmc.org/articles/PMC8966356/
Autor:
Jesse C. Cochrane, Sharon K. Marr, Maud-Emmanuelle Gilles, Teddy Jégu, Lin Yang, Robert E. Kingston, Attila Szanto, Chen-Yu Wang, David Colognori, Roy Blum, Jeannie T. Lee
Publikováno v:
Nature structural & molecular biology
The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape of Xi and assess how Xist alters chromatin accessibility. Interesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effa54d6b9294afc5e9a17eb6d45eddf
https://doi.org/10.1038/s41594-018-0176-8
https://doi.org/10.1038/s41594-018-0176-8
Autor:
Leandro Royer, Michael T. Marr, Jesse C. Cochrane, Josiah J. Herzog, Suzanne Paradis, Katelyn Kenny, Boriana Tzvetkova
Publikováno v:
The Journal of biological chemistry. 293(38)
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a well-characterized, abundant protein kinase that regulates a diverse set of functions in a tissue-specific manner. For example, in heart muscle, CaMKII regulates Ca(2+) homeostasis, whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637ee59586b2a9704a2f2e9501a68630
https://pubmed.ncbi.nlm.nih.gov/30072381
https://pubmed.ncbi.nlm.nih.gov/30072381
Autor:
Suzanne Paradis, Jesse C. Cochrane, Michael T. Marr, Katelyn Kenny, Leandro Royer, Boriana Tzvetkova, Josiah J. Herzog
CaMKII is a well-characterized, abundant protein kinase that regulates a diverse set of functions in a tissue specific manner. For example, in heart muscle, CaMKII regulates Ca2+homeostasis while in neurons CaMKII regulates activity-dependent dendrit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2ff5cb8cd5c8544d4e11a531d291c8
Publikováno v:
RNA. 16:762-768
The kink turn (K-turn) is an RNA structural motif found in many biologically significant RNAs. While most examples of the K-turn have a similar fold, the crystal structure of the Azoarcus group I intron revealed a novel RNA conformation, a reverse ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf11537f1d8d026108e8d455eb94fbc
https://doi.org/10.1261/rna.1883810
https://doi.org/10.1261/rna.1883810
Autor:
Scott A. Strobel, Jesse C. Cochrane
Publikováno v:
Accounts of Chemical Research. 41:1027-1035
[Structure: see text]. Five naturally occurring nucleolytic ribozymes have been identified: the hammerhead, hairpin, glmS, hepatitis delta virus (HDV), and Varkud satellite (VS) ribozymes. All of these RNA enzymes catalyze self-scission of the RNA ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e592d9ab21154e90f9bd57db115db5bb
https://doi.org/10.1021/ar800050c
https://doi.org/10.1021/ar800050c
Autor:
Scott A. Strobel, Jesse C. Cochrane
Publikováno v:
RNA. 14:993-1002
The recently identified glmS ribozyme revealed that RNA enzymes, like protein enzymes, are capable of using small molecules as catalytic cofactors to promote chemical reactions. Flavin mononucleotide (FMN), S-adenosyl methionine (SAM), adenosyl cobal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8949abc497337412cbc05fad6334495f
https://doi.org/10.1261/rna.908408
https://doi.org/10.1261/rna.908408
Autor:
Jhumku D. Kohtz, James Thompson, Kelsey R. Swyter, Robert E. Kingston, Jesse C. Cochrane, David E. Leib, John R. Yates, Sean Chen, Brian S. Clark, Ivelisse Cajigas, Hao Luo
Publikováno v:
Development.
Transcription-regulating long non-coding RNAs (lncRNAs) have the potential to control the site-specific expression of thousands of target genes. Previously, we showed that Evf2, the first described ultraconserved lncRNA, increases the association of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::506b17b6353ba5928ccc1a1f26e73a4b
https://doi.org/10.1242/dev.126318
https://doi.org/10.1242/dev.126318
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2305-2309
We designed a single-chain variant of the Arc repressor homodimer in which the β strands that contact operator DNA are connected by a hairpin turn and the α helices that form the tetrahelical scaffold of the dimer are attached by a short linker. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b44efd059a2b9e91ebb07fdd75668fa
https://doi.org/10.1073/pnas.0409562102
https://doi.org/10.1073/pnas.0409562102
Autor:
Anthony Anselmo, Sharmistha Kundu, Ruslan I. Sadreyev, M. Behfar Ardehali, Jesse C. Cochrane, Robert E. Kingston
Publikováno v:
Molecular Cell. 68:872-884.e6
Summary Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development. Misregulation of PRC2 is linked to a range of neoplastic malignancies, which is believed to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e55c49d94b2d815eb6419bf6f79deb
https://doi.org/10.1016/j.molcel.2017.10.025
https://doi.org/10.1016/j.molcel.2017.10.025