Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jesse C Wiley"'
Autor:
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0293548 (2024)
RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. FCER1G is a component of Fc recept
Externí odkaz:
https://doaj.org/article/a694cd69ff044329bed258122700d8e8
Autor:
Suman Jayadev, Amanda Case, Alison J Eastman, Huy Nguyen, Julia Pollak, Jesse C Wiley, Thomas Möller, Richard S Morrison, Gwenn A Garden
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15743 (2010)
Presenilin 1 (PS1) and Presenilin 2 (PS2) are the enzymatic component of the γ-secretase complex that cleaves amyloid precursor protein (APP) to release amyloid beta (Aβ) peptide. PS deficiency in mice results in neuroinflammation and neurodegenera
Externí odkaz:
https://doaj.org/article/9d85599e9a854eae9bfd0229c82744c4
Autor:
Jesse C Wiley, James S Meabon, Harald Frankowski, Elise A Smith, Leslayann C Schecterson, Mark Bothwell, Warren C Ladiges
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9135 (2010)
BACKGROUND: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer'
Externí odkaz:
https://doaj.org/article/93fef6035ed349bf90e598ff0b771e94
Autor:
Jake Gockley, Kelsey S. Montgomery, William L. Poehlman, Jesse C. Wiley, Yue Liu, Ekaterina Gerasimov, Anna K. Greenwood, Solveig K. Sieberts, Aliza P. Wingo, Thomas S. Wingo, Lara M. Mangravite, Benjamin A. Logsdon
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Alzheimer’s disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying common genetic variants driving differences in transcript exp
Externí odkaz:
https://doaj.org/article/cc1326de139a4ed99b3067c6cdc456ec
APOE is one of the strongest risk factors for late onset AD (LOAD) with a multitude of plausible biological effects in both neuronal and glial systems that could promote neurodegenerative processes, which are discussed in the section below. The goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071f01fcf7ff88bd2294487c5fa238fd
QPRT is a core enzyme involved in the conversion of tryptophan to NAD which was identified in deep proteomic studies of the human brain to be associated with AD pathology and cognitive decline (see below for details and citations). The goal of this T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef016c2f61c4af2fc9c1707c0a0e7a7
Autor:
Laura M Heath, Jesse C Wiley, Gregory A. Cary, William L. Poehlman, Jake Gockley, Gregory W Carter, Anna K Greenwood, Lara M Mangravite
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6959436d7c5b6a313e532c5ab1c31d03
https://doi.org/10.1002/alz.068215
https://doi.org/10.1002/alz.068215
Autor:
Jesse C Wiley, Jessica E. Young, Suman Jayadev, Martin Darvas, Russell H Swerdlow, Michael S. Wolfe, Laura M Heath, Jake Gockley, Gregory A. Cary, William L. Poehlman, Warren Ladiges, Gregory W Carter, Mark A Bothwell, Anna K Greenwood, Lara M Mangravite
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f33ebaf49b0b1426618217870c72ad
https://doi.org/10.1002/alz.068190
https://doi.org/10.1002/alz.068190
Autor:
Solveig K. Sieberts, Thomas S. Wingo, Anna K. Greenwood, Jake Gockley, Jesse C. Wiley, William L. Poehlman, Kelsey S. Montgomery, Ekaterina S. Gerasimov, Aliza P. Wingo, Lara M. Mangravite, Yue Liu, Benjamin A. Logsdon
Publikováno v:
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Background Alzheimer’s disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying common genetic variants driving differences in transcript expression t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf6aa04560fcd6a6e61e5d25970d3fa
https://doi.org/10.1101/2020.06.29.178590
https://doi.org/10.1101/2020.06.29.178590
Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 4, Iss 1, Pp 1-7 (2018)
npj Parkinson's Disease, Vol 4, Iss 1, Pp 1-7 (2018)
The diagnosis of Parkinson’s disease (PD) currently relies almost exclusively on the clinical judgment of an experienced neurologist, ideally a specialist in movement disorders. However, such clinical diagnosis is often incorrect in a large percent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8988f954ae5a16c46351a54627ccd1
http://europepmc.org/articles/PMC5824845
http://europepmc.org/articles/PMC5824845